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  • The following terms were not found in MedGen: <<@JYP24>>, nmid.

Pyrexia of unknown origin

MedGen UID:
42012
•Concept ID:
C0015970
•
Sign or Symptom
Synonyms: Fever of Unknown Origin; Unknown Origin Fever; Unknown Origin Fevers
SNOMED CT: PUO - Pyrexia of unknown origin (7520000); Fever of unknown origin (7520000); F.U.O. (7520000); Pyrexia of unknown origin (7520000)

Definition

A febrile process with an etiology that is not apparent or yet determined. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPyrexia of unknown origin

Professional guidelines

PubMed

Fever of Unknown Origin (FUO) - A Call for New Research Standards and Updated Clinical Management.
Wright WF, Mulders-Manders CM, Auwaerter PG, Bleeker-Rovers CP
Am J Med 2022 Feb;135(2):173-178. Epub 2021 Aug 24 doi: 10.1016/j.amjmed.2021.07.038. PMID: 34437835
Clinical presentations, microbiology and management outcomes of culture-proven endogenous endophthalmitis in India.
Dave VP, Pathengay A, Panchal B, Jindal A, Datta A, Sharma S, Pappuru RR, Joseph J, Jalali S, Das T
Indian J Ophthalmol 2020 May;68(5):834-839. doi: 10.4103/ijo.IJO_1091_19. PMID: 32317456Free PMC Article
Pyrexia of unknown origin: causes, investigation and management.
Beresford RW, Gosbell IB
Intern Med J 2016 Sep;46(9):1011-6. doi: 10.1111/imj.13180. PMID: 27633467

Recent clinical studies

Etiology

Rickettsial Infection amongst Febrile Illness Patient in a Tertiary Care Hospital: A Retrospective Cross-sectional Study.
Gurung RB , Sapkota P , Bhatt S , Tamang A , Joshi S , Khadka S , Jaisy DN , Chalise S , Shrestha P
Kathmandu Univ Med J (KUMJ) 2022 Jul-Sep;20(79):366-371. PMID: 37042381
Pyrexia of unknown origin and its aetiology in Pakistan.
Akhtar W, Awan S, Ishaq U, Malik A, Malik J, Zaidi SMJ
Trop Doct 2022 Oct;52(4):567-571. Epub 2022 Jul 14 doi: 10.1177/00494755221096902. PMID: 35833343
Prospective Studies Comparing Structured vs Nonstructured Diagnostic Protocol Evaluations Among Patients With Fever of Unknown Origin: A Systematic Review and Meta-analysis.
Wright WF, Betz JF, Auwaerter PG
JAMA Netw Open 2022 Jun 1;5(6):e2215000. doi: 10.1001/jamanetworkopen.2022.15000. PMID: 35653154Free PMC Article
Pyrexia of unknown origin.
Fernandez C, Beeching NJ
Clin Med (Lond) 2018 Mar;18(2):170-174. doi: 10.7861/clinmedicine.18-2-170. PMID: 29626024Free PMC Article
Familial haemophagocytic lymphohistiocytosis: advances in the genetic basis, diagnosis and management.
Gholam C, Grigoriadou S, Gilmour KC, Gaspar HB
Clin Exp Immunol 2011 Mar;163(3):271-83. doi: 10.1111/j.1365-2249.2010.04302.x. PMID: 21303357Free PMC Article

Diagnosis

Prospective Studies Comparing Structured vs Nonstructured Diagnostic Protocol Evaluations Among Patients With Fever of Unknown Origin: A Systematic Review and Meta-analysis.
Wright WF, Betz JF, Auwaerter PG
JAMA Netw Open 2022 Jun 1;5(6):e2215000. doi: 10.1001/jamanetworkopen.2022.15000. PMID: 35653154Free PMC Article
Fever of Unknown Origin (FUO) - A Call for New Research Standards and Updated Clinical Management.
Wright WF, Mulders-Manders CM, Auwaerter PG, Bleeker-Rovers CP
Am J Med 2022 Feb;135(2):173-178. Epub 2021 Aug 24 doi: 10.1016/j.amjmed.2021.07.038. PMID: 34437835
Pyrexia of unknown origin.
Fernandez C, Beeching NJ
Clin Med (Lond) 2018 Mar;18(2):170-174. doi: 10.7861/clinmedicine.18-2-170. PMID: 29626024Free PMC Article
Childhood Brucellosis in Eastern India.
Dutta D, Sen A, Gupta D, Kuila P, Chatterjee D, Sanyal S, Das S
Indian J Pediatr 2018 Apr;85(4):266-271. Epub 2017 Oct 26 doi: 10.1007/s12098-017-2513-z. PMID: 29071584
Pyrexia of unknown origin: causes, investigation and management.
Beresford RW, Gosbell IB
Intern Med J 2016 Sep;46(9):1011-6. doi: 10.1111/imj.13180. PMID: 27633467

Therapy

Prospective Studies Comparing Structured vs Nonstructured Diagnostic Protocol Evaluations Among Patients With Fever of Unknown Origin: A Systematic Review and Meta-analysis.
Wright WF, Betz JF, Auwaerter PG
JAMA Netw Open 2022 Jun 1;5(6):e2215000. doi: 10.1001/jamanetworkopen.2022.15000. PMID: 35653154Free PMC Article
Granulomatous nephritis: A rare presentation of juvenile-onset sarcoidosis.
Chotalia P, Pandya S, Srivastava P
Mod Rheumatol Case Rep 2022 Jan 7;6(1):111-114. doi: 10.1093/mrcr/rxab011. PMID: 34508265
How to investigate multisystem disease.
Watts RA
Best Pract Res Clin Rheumatol 2014 Dec;28(6):831-43. Epub 2015 May 18 doi: 10.1016/j.berh.2015.04.011. PMID: 26096088
Disseminated cryptococcosis.
Bothra M, Selvaperumal P, Kabra M, Joshi P
Indian Pediatr 2014 Mar;51(3):225-6. doi: 10.1007/s13312-014-0356-5. PMID: 24736916
Human brucellosis: review of an under-diagnosed animal transmitted disease.
Thakur SD, Kumar R, Thapliyal DC
J Commun Dis 2002 Dec;34(4):287-301. PMID: 14710861

Prognosis

Granulomatous hepatitis by Nocardia species: An unusual case.
Singh S, Verma Y, Pandey P, Singh UB
Int J Infect Dis 2019 Apr;81:97-99. Epub 2019 Feb 4 doi: 10.1016/j.ijid.2019.01.046. PMID: 30731130
Tuberculosis in dialysis: Clinical spectrum and outcome from an endemic region.
Vikrant S
Hemodial Int 2019 Jan;23(1):88-92. Epub 2018 Oct 5 doi: 10.1111/hdi.12693. PMID: 30289617
Increasing incidence of Rickettsial infection in patients of Pyrexia of Unknown Origin.
Goyal PK, Babu R, Agarwal S, Behal KA, Behal K
J Assoc Physicians India 2018 Jun;66(6):46-48. PMID: 31331135
Pyrexia of unknown origin.
Fernandez C, Beeching NJ
Clin Med (Lond) 2018 Mar;18(2):170-174. doi: 10.7861/clinmedicine.18-2-170. PMID: 29626024Free PMC Article
An avoidable cause of cardioembolic stroke.
O'Kane D, Pusalkar A, Topping W, Spooner O, Roantree E
Acute Med 2014;13(3):126-8. PMID: 25229064

Clinical prediction guides

Prospective study of pyrexia with pregnancy.
Mewada BN, Gandhi D, Diwan F, Panchal PN
Ann Afr Med 2023 Jan-Mar;22(1):1-4. doi: 10.4103/aam.aam_75_20. PMID: 36695215Free PMC Article
Epidemic retinitis and community outbreaks.
Kawali A, Srinivasan S, Mahendradas P, Shetty B
Indian J Ophthalmol 2020 Sep;68(9):1916-1919. doi: 10.4103/ijo.IJO_1327_20. PMID: 32823414Free PMC Article
Disseminated cryptococcosis.
Bothra M, Selvaperumal P, Kabra M, Joshi P
Indian Pediatr 2014 Mar;51(3):225-6. doi: 10.1007/s13312-014-0356-5. PMID: 24736916
Rare manifestations of sarcoidosis in modern era of new diagnostic tools.
Sharma SK, Soneja M, Sharma A, Sharma MC, Hari S
Indian J Med Res 2012 May;135(5):621-9. PMID: 22771590Free PMC Article
Occurrence of leptospirosis among suspected cases in Chennai, Tamil Nadu.
Arumugam G, Jacob SM, Anitha D, Rajappa SM
Indian J Pathol Microbiol 2011 Jan-Mar;54(1):100-2. doi: 10.4103/0377-4929.77340. PMID: 21393887

Recent systematic reviews

Prospective Studies Comparing Structured vs Nonstructured Diagnostic Protocol Evaluations Among Patients With Fever of Unknown Origin: A Systematic Review and Meta-analysis.
Wright WF, Betz JF, Auwaerter PG
JAMA Netw Open 2022 Jun 1;5(6):e2215000. doi: 10.1001/jamanetworkopen.2022.15000. PMID: 35653154Free PMC Article
Mycotic aneurysm of the superior and inferior mesenteric artery.
Kordzadeh A, Watson J, Panayiotopolous YP
J Vasc Surg 2016 Jun;63(6):1638-46. Epub 2016 Mar 4 doi: 10.1016/j.jvs.2016.01.031. PMID: 26951998
Is there a role for the otolaryngologist in PFAPA syndrome? A systematic review.
Leong SC, Karkos PD, Apostolidou MT
Int J Pediatr Otorhinolaryngol 2006 Nov;70(11):1841-5. Epub 2006 Aug 14 doi: 10.1016/j.ijporl.2006.07.002. PMID: 16908073

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