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  • The following term was not found in MedGen: farnesyltransferase.

Protein Prenylation

MedGen UID:
57980
•Concept ID:
C0162766
•
Molecular Function
Synonym: Prenylation, Protein

Definition

A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProtein Prenylation

Professional guidelines

PubMed

Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers.
Waller DD, Park J, Tsantrizos YS
Crit Rev Biochem Mol Biol 2019 Feb;54(1):41-60. Epub 2019 Feb 18 doi: 10.1080/10409238.2019.1568964. PMID: 30773935
Statins in the treatment of central nervous system autoimmune disease.
Weber MS, Youssef S, Dunn SE, Prod'homme T, Neuhaus O, Stuve O, Greenwood J, Steinman L, Zamvil SS
J Neuroimmunol 2006 Sep;178(1-2):140-8. Epub 2006 Jul 24 doi: 10.1016/j.jneuroim.2006.06.006. PMID: 16860400
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
Buckner FS, Eastman RT, Yokoyama K, Gelb MH, Van Voorhis WC
Curr Opin Investig Drugs 2005 Aug;6(8):791-7. PMID: 16121685

Recent clinical studies

Etiology

Structure, catalysis, and inhibition mechanism of prenyltransferase.
Chang HY, Cheng TH, Wang AH
IUBMB Life 2021 Jan;73(1):40-63. Epub 2020 Nov 27 doi: 10.1002/iub.2418. PMID: 33246356Free PMC Article
Statins: benefits and risks revisited.
Balaz M, Wolfrum C
Aging (Albany NY) 2019 Jul 14;11(13):4300-4302. doi: 10.18632/aging.102056. PMID: 31303605Free PMC Article
Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
Jeong A, Suazo KF, Wood WG, Distefano MD, Li L
Crit Rev Biochem Mol Biol 2018 Jun;53(3):279-310. doi: 10.1080/10409238.2018.1458070. PMID: 29718780Free PMC Article
Advances in Fmoc solid-phase peptide synthesis.
Behrendt R, White P, Offer J
J Pept Sci 2016 Jan;22(1):4-27. doi: 10.1002/psc.2836. PMID: 26785684Free PMC Article
Protein farnesylation and disease.
Novelli G, D'Apice MR
J Inherit Metab Dis 2012 Sep;35(5):917-26. Epub 2012 Feb 4 doi: 10.1007/s10545-011-9445-y. PMID: 22307208

Diagnosis

USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer.
Maier CR, Hartmann O, Prieto-Garcia C, Al-Shami KM, Schlicker L, Vogel FCE, Haid S, Klann K, Buck V, Münch C, Schmitz W, Einig E, Krenz B, Calzado MA, Eilers M, Popov N, Rosenfeldt MT, Diefenbacher ME, Schulze A
Cell Death Differ 2023 Jul;30(7):1710-1725. Epub 2023 May 18 doi: 10.1038/s41418-023-01173-6. PMID: 37202505Free PMC Article
Compromised Protein Prenylation as Pathogenic Mechanism in Mevalonate Kinase Deficiency.
Politiek FA, Waterham HR
Front Immunol 2021;12:724991. Epub 2021 Sep 3 doi: 10.3389/fimmu.2021.724991. PMID: 34539662Free PMC Article
Management of hepatitis delta: Need for novel therapeutic options.
Abbas Z, Abbas M
World J Gastroenterol 2015 Aug 28;21(32):9461-5. doi: 10.3748/wjg.v21.i32.9461. PMID: 26327754Free PMC Article
Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation.
Xu N, Shen N, Wang X, Jiang S, Xue B, Li C
Sci China Life Sci 2015 Apr;58(4):328-35. Epub 2015 Apr 11 doi: 10.1007/s11427-015-4836-1. PMID: 25862656
Small GTPases in acrosomal exocytosis.
Bustos MA, Lucchesi O, Ruete MC, Mayorga LS, Tomes CN
Methods Mol Biol 2015;1298:141-60. doi: 10.1007/978-1-4939-2569-8_12. PMID: 25800839

Therapy

Statins: benefits and risks revisited.
Balaz M, Wolfrum C
Aging (Albany NY) 2019 Jul 14;11(13):4300-4302. doi: 10.18632/aging.102056. PMID: 31303605Free PMC Article
Protein prenylation: enzymes, therapeutics, and biotechnology applications.
Palsuledesai CC, Distefano MD
ACS Chem Biol 2015 Jan 16;10(1):51-62. Epub 2014 Dec 8 doi: 10.1021/cb500791f. PMID: 25402849Free PMC Article
Lonafarnib for cancer and progeria.
Wong NS, Morse MA
Expert Opin Investig Drugs 2012 Jul;21(7):1043-55. Epub 2012 May 24 doi: 10.1517/13543784.2012.688950. PMID: 22620979
Statins and protein prenylation in cancer cell biology and therapy.
Garcia-Ruiz C, Morales A, Fernandez-Checa JC
Anticancer Agents Med Chem 2012 May;12(4):303-15. doi: 10.2174/187152012800228715. PMID: 22413970
Statins and demyelination.
Weber MS, Zamvil SS
Curr Top Microbiol Immunol 2008;318:313-24. doi: 10.1007/978-3-540-73677-6_12. PMID: 18219823

Prognosis

GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
Kuchay S, Wang H, Marzio A, Jain K, Homer H, Fehrenbacher N, Philips MR, Zheng N, Pagano M
Nat Struct Mol Biol 2019 Jul;26(7):628-636. Epub 2019 Jun 17 doi: 10.1038/s41594-019-0249-3. PMID: 31209342Free PMC Article
Prenylation of viral proteins by enzymes of the host: Virus-driven rationale for therapy with statins and FT/GGT1 inhibitors.
Marakasova ES, Eisenhaber B, Maurer-Stroh S, Eisenhaber F, Baranova A
Bioessays 2017 Oct;39(10) Epub 2017 Sep 8 doi: 10.1002/bies.201700014. PMID: 28885709
Treatment of delta hepatitis.
Gunsar F
Expert Rev Anti Infect Ther 2013 May;11(5):489-98. doi: 10.1586/eri.13.35. PMID: 23627855
Isoprenoids, small GTPases and Alzheimer's disease.
Hooff GP, Wood WG, Müller WE, Eckert GP
Biochim Biophys Acta 2010 Aug;1801(8):896-905. Epub 2010 Apr 8 doi: 10.1016/j.bbalip.2010.03.014. PMID: 20382260Free PMC Article
Protein prenyltransferases.
Maurer-Stroh S, Washietl S, Eisenhaber F
Genome Biol 2003;4(4):212. Epub 2003 Apr 1 doi: 10.1186/gb-2003-4-4-212. PMID: 12702202Free PMC Article

Clinical prediction guides

RABGGTB plays a critical role in ALS pathogenesis.
Ma H, Huo J, Xin C, Yang J, Liu Q, Dong H, Li R, Liu Y
Brain Res Bull 2024 Jan;206:110833. Epub 2023 Dec 1 doi: 10.1016/j.brainresbull.2023.110833. PMID: 38042502
New Approaches to the Prevention and Treatment of Viral Diseases.
Pronin AV, Narovlyansky AN, Sanin AV
Arch Immunol Ther Exp (Warsz) 2021 Apr 3;69(1):10. doi: 10.1007/s00005-021-00613-w. PMID: 33811524Free PMC Article
Protein farnesylation and disease.
Novelli G, D'Apice MR
J Inherit Metab Dis 2012 Sep;35(5):917-26. Epub 2012 Feb 4 doi: 10.1007/s10545-011-9445-y. PMID: 22307208
Protein prenyltransferases.
Maurer-Stroh S, Washietl S, Eisenhaber F
Genome Biol 2003;4(4):212. Epub 2003 Apr 1 doi: 10.1186/gb-2003-4-4-212. PMID: 12702202Free PMC Article
Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics.
Cohen LH, Pieterman E, van Leeuwen RE, Overhand M, Burm BE, van der Marel GA, van Boom JH
Biochem Pharmacol 2000 Oct 15;60(8):1061-8. doi: 10.1016/s0006-2952(00)00386-5. PMID: 11007942

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