U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Diabetic embryopathy

MedGen UID:
823266
•Concept ID:
C3830518
•
Disease or Syndrome
Synonyms: Diabetic Embryopathy; diabetic embryopathy
SNOMED CT: Diabetic embryopathy (716020005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016018
Orphanet: ORPHA1926

Definition

Congenital anomalies or fetal/neonatal complications in an infant that are linked to diabetes in the mother. In infants of women with established insulin-dependent diabetes mellitus, the risk of congenital malformations is 10 times higher than that in the general population, and the rate of stillbirths is five times higher than that in the general population. Macrosomia is also a common problem among infants of women with established insulin-dependent diabetes mellitus. Excess mortality among infants of women with preexisting insulin-dependent diabetes mellitus is predominantly due to congenital malformations. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic embryopathy

Professional guidelines

PubMed

Prenatal diagnosis and prevention of diabetic embryopathy.
Reece EA, Homko CJ, Hagay Z
Obstet Gynecol Clin North Am 1996 Mar;23(1):11-28. doi: 10.1016/s0889-8545(05)70242-4. PMID: 8684774
Assessment and management of pregnancies complicated by pregestational and gestational diabetes mellitus.
Reece EA, Homko CJ
J Assoc Acad Minor Phys 1994;5(3):87-97. PMID: 7949826
Diabetic embryopathy: pathogenesis, prenatal diagnosis and prevention.
Reece EA, Hobbins JC
Obstet Gynecol Surv 1986 Jun;41(6):325-35. PMID: 2423939

Recent clinical studies

Etiology

Congenital Abnormalities in the Infant of a Diabetic Mother.
Kokhanov A
Neoreviews 2022 May 1;23(5):e319-e327. doi: 10.1542/neo.23-5-e319. PMID: 35490182
Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model.
Ali H, Hasmiwati, Rasyid R, Handayani D, Endrinaldi, Usman E, Basyir V, Yerizel E, Decroli E
J Complement Integr Med 2022 Sep 1;19(3):619-626. Epub 2022 Apr 25 doi: 10.1515/jcim-2021-0549. PMID: 35470646
Imaging Review of Obstetric Sequelae of Maternal Diabetes Mellitus.
Aboughalia H, Pathak P, Basavalingu D, Chapman T, Revzin MV, Sienas LE, Deutsch GH, Katz DS, Moshiri M
Radiographics 2022 Jan-Feb;42(1):302-319. Epub 2021 Dec 2 doi: 10.1148/rg.210164. PMID: 34855544
Mechanisms of Congenital Malformations in Pregnancies with Pre-existing Diabetes.
Loeken MR
Curr Diab Rep 2020 Sep 12;20(10):54. doi: 10.1007/s11892-020-01338-4. PMID: 32918152Free PMC Article
Heterogeneous Diagnoses Underlying Radial Ray Anomalies.
Sevilla-Montoya R, Aguinaga M, Martínez A, Razo G, Molina B, Frías S, Grether P
Indian J Pediatr 2017 Mar;84(3):200-205. Epub 2016 Dec 17 doi: 10.1007/s12098-016-2270-4. PMID: 27987078

Diagnosis

Diabetic Embryopathies.
Gajagowni S, Nair P, Bapat AC, Vachharajani AJ
Neoreviews 2022 Oct 1;23(10):e677-e688. doi: 10.1542/neo.23-10-e677. PMID: 36180736
Congenital Abnormalities in the Infant of a Diabetic Mother.
Kokhanov A
Neoreviews 2022 May 1;23(5):e319-e327. doi: 10.1542/neo.23-5-e319. PMID: 35490182
Experience with cultured thymus tissue in 105 children.
Markert ML, Gupton SE, McCarthy EA
J Allergy Clin Immunol 2022 Feb;149(2):747-757. Epub 2021 Aug 4 doi: 10.1016/j.jaci.2021.06.028. PMID: 34362576Free PMC Article
Heterogeneous Diagnoses Underlying Radial Ray Anomalies.
Sevilla-Montoya R, Aguinaga M, Martínez A, Razo G, Molina B, Frías S, Grether P
Indian J Pediatr 2017 Mar;84(3):200-205. Epub 2016 Dec 17 doi: 10.1007/s12098-016-2270-4. PMID: 27987078
New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects.
Dong D, Reece EA, Lin X, Wu Y, AriasVillela N, Yang P
Am J Obstet Gynecol 2016 Feb;214(2):192-202. Epub 2015 Sep 30 doi: 10.1016/j.ajog.2015.09.082. PMID: 26432466Free PMC Article

Therapy

Nigericin Abrogates Maternal and Embryonic Oxidative Stress in the Streptozotocin-Induced Diabetic Pregnant Rats.
Guo H, Zhang Q, Li R, Seshadri VD
Appl Biochem Biotechnol 2023 Feb;195(2):801-815. Epub 2022 Oct 3 doi: 10.1007/s12010-022-04100-6. PMID: 36190644
Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model.
Ali H, Hasmiwati, Rasyid R, Handayani D, Endrinaldi, Usman E, Basyir V, Yerizel E, Decroli E
J Complement Integr Med 2022 Sep 1;19(3):619-626. Epub 2022 Apr 25 doi: 10.1515/jcim-2021-0549. PMID: 35470646
Diabetes-induced birth defects: what do we know? What can we do?
Reece EA
Curr Diab Rep 2012 Feb;12(1):24-32. doi: 10.1007/s11892-011-0251-6. PMID: 22167469
Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy.
Ornoy A
Reprod Toxicol 2007 Jul;24(1):31-41. Epub 2007 Apr 27 doi: 10.1016/j.reprotox.2007.04.004. PMID: 17548185
Advanced glycation endproducts--role in pathology of diabetic complications.
Ahmed N
Diabetes Res Clin Pract 2005 Jan;67(1):3-21. doi: 10.1016/j.diabres.2004.09.004. PMID: 15620429

Prognosis

Nigericin Abrogates Maternal and Embryonic Oxidative Stress in the Streptozotocin-Induced Diabetic Pregnant Rats.
Guo H, Zhang Q, Li R, Seshadri VD
Appl Biochem Biotechnol 2023 Feb;195(2):801-815. Epub 2022 Oct 3 doi: 10.1007/s12010-022-04100-6. PMID: 36190644
Maternal diabetes-related malformations in Utah: A population study of birth prevalence 2001-2016.
Orbain MM, Johnson J, Nance A, Romeo AN, Silver MA, Martinez L, Leen-Mitchell M, Carey JC
Birth Defects Res 2021 Jan 15;113(2):152-160. Epub 2020 Nov 23 doi: 10.1002/bdr2.1843. PMID: 33226174
A novel association of biventricular cardiac noncompaction and diabetic embryopathy: case report and review of the literature.
Woo JS, Perez-Rosendahl M, Haydel D, Perens G, Fishbein MC
Pediatr Dev Pathol 2015 Jan-Feb;18(1):71-5. Epub 2014 Nov 11 doi: 10.2350/14-07-1532-CR.1. PMID: 25386687
Developmental renal pathology: its past, present, and future.
Rodriguez MM
Fetal Pediatr Pathol 2004 Jul-Aug;23(4):211-29. doi: 10.1080/15227950490923453. PMID: 16095033
Assessment and management of pregnancies complicated by pregestational and gestational diabetes mellitus.
Reece EA, Homko CJ
J Assoc Acad Minor Phys 1994;5(3):87-97. PMID: 7949826

Clinical prediction guides

Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model.
Ali H, Hasmiwati, Rasyid R, Handayani D, Endrinaldi, Usman E, Basyir V, Yerizel E, Decroli E
J Complement Integr Med 2022 Sep 1;19(3):619-626. Epub 2022 Apr 25 doi: 10.1515/jcim-2021-0549. PMID: 35470646
Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy.
Ornoy A
Reprod Toxicol 2007 Jul;24(1):31-41. Epub 2007 Apr 27 doi: 10.1016/j.reprotox.2007.04.004. PMID: 17548185
Developmental renal pathology: its past, present, and future.
Rodriguez MM
Fetal Pediatr Pathol 2004 Jul-Aug;23(4):211-29. doi: 10.1080/15227950490923453. PMID: 16095033
Maternal hypoglycemia during pregnancy in type 1 diabetes: maternal and fetal consequences.
ter Braak EW, Evers IM, Willem Erkelens D, Visser GH
Diabetes Metab Res Rev 2002 Mar-Apr;18(2):96-105. doi: 10.1002/dmrr.271. PMID: 11994900
Prostaglandylinositol cyclic phosphate (cPIP): a novel second messenger of insulin action. Comparative analysis of two kinds of "insulin mediators".
Shashkin PN, Wasner HK, Ortmeyer HK, Hansen BC
Diabetes Metab Res Rev 2001 Jul-Aug;17(4):273-84. doi: 10.1002/dmrr.218. PMID: 11544611

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...