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  • The following term was not found in MedGen: taurica.

Paraneoplastic Opsoclonus Ataxia

MedGen UID:
234606
•Concept ID:
C1377828
•
Sign or Symptom
Synonyms: Paraneoplastic Opsoclonus-Ataxia; POA

Definition

Ataxia associated with chaotic multidirectional conjugate eye movements secondary to metastatic tumors to cerebellum. The most common malignant tumor associated with this paraneoplastic syndrome is lung carcinoma. (NCI) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaneoplastic Opsoclonus Ataxia

Professional guidelines

PubMed

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Downbeat nystagmus: a clinical review of diagnosis and management.
Tran TM, Lee MS, McClelland CM
Curr Opin Ophthalmol 2021 Nov 1;32(6):504-514. doi: 10.1097/ICU.0000000000000802. PMID: 34456290
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article

Recent clinical studies

Etiology

Autoimmune central nervous system paraneoplastic disorders: mechanisms, diagnosis, and therapeutic options.
Dropcho EJ
Ann Neurol 1995 May;37 Suppl 1:S102-13. doi: 10.1002/ana.410370711. PMID: 8968221

Diagnosis

CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer.
Nakajima M, Uchibori A, Ogawa Y, Miyazaki T, Ichikawa Y, Kaneko K, Takahashi T, Nakashima I, Shiraishi H, Motomura M, Chiba A
Intern Med 2018 Jun 1;57(11):1645-1649. Epub 2018 Jan 11 doi: 10.2169/internalmedicine.9736-17. PMID: 29321433Free PMC Article
Opsoclonus-ataxia syndrome associated with ovarian mature teratoma.
Kanno K, Kin S, Hirose M, Suzuki S, Watanabe T, Fujimori K
J Obstet Gynaecol Res 2015 Jul;41(7):1149-53. Epub 2015 Mar 15 doi: 10.1111/jog.12675. PMID: 25772013
Autoimmune central nervous system paraneoplastic disorders: mechanisms, diagnosis, and therapeutic options.
Dropcho EJ
Ann Neurol 1995 May;37 Suppl 1:S102-13. doi: 10.1002/ana.410370711. PMID: 8968221

Therapy

Autoimmune central nervous system paraneoplastic disorders: mechanisms, diagnosis, and therapeutic options.
Dropcho EJ
Ann Neurol 1995 May;37 Suppl 1:S102-13. doi: 10.1002/ana.410370711. PMID: 8968221

Prognosis

Opsoclonus-ataxia syndrome associated with ovarian mature teratoma.
Kanno K, Kin S, Hirose M, Suzuki S, Watanabe T, Fujimori K
J Obstet Gynaecol Res 2015 Jul;41(7):1149-53. Epub 2015 Mar 15 doi: 10.1111/jog.12675. PMID: 25772013

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