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  • The following terms were not found in MedGen: opsmall, CyrillicopopTauop<, CyrillicopopTauop<-->.

HIV Budding

MedGen UID:
268821
•Concept ID:
C1512301
•
Molecular Function

Definition

HIV Budding is a process in which newly generated viral RNA and protein complexes are assembled at, packaged in, and released from the cell surface membrane taking a piece of the cell membrane to form their own viral membranes. To bud from infected cells, HIV-1 employs several host proteins such as endosomal sorting protein Tsg101, which functions in the Vps pathway. The L domain (PTAP) in the p6 domain of HIV-1 Gag interacts with the N-terminal domain of TSG101; the Vps28-binding domain of TSG101 inhibits budding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHIV Budding

Professional guidelines

PubMed

Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment.
Woodham AW, Skeate JG, Sanna AM, Taylor JR, Da Silva DM, Cannon PM, Kast WM
AIDS Patient Care STDS 2016 Jul;30(7):291-306. doi: 10.1089/apc.2016.0100. PMID: 27410493Free PMC Article
Histoplasmosis: cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology.
Gupta N, Arora SK, Rajwanshi A, Nijhawan R, Srinivasan R
Cytopathology 2010 Aug;21(4):240-4. Epub 2009 Oct 15 doi: 10.1111/j.1365-2303.2009.00693.x. PMID: 19843140
HIV protease inhibitors: their anti-HIV activity and potential role in treatment.
Robins T, Plattner J
J Acquir Immune Defic Syndr (1988) 1993 Feb;6(2):162-70. PMID: 8433280

Recent clinical studies

Etiology

Model of human immunodeficiency virus budding and self-assembly: role of the cell membrane.
Zhang R, Nguyen TT
Phys Rev E Stat Nonlin Soft Matter Phys 2008 Nov;78(5 Pt 1):051903. Epub 2008 Nov 5 doi: 10.1103/PhysRevE.78.051903. PMID: 19113151

Diagnosis

The Race against Protease Activation Defines the Role of ESCRTs in HIV Budding.
Bendjennat M, Saffarian S
PLoS Pathog 2016 Jun;12(6):e1005657. Epub 2016 Jun 9 doi: 10.1371/journal.ppat.1005657. PMID: 27280284Free PMC Article
Antigp41 antibodies fail to block early events of virological synapses but inhibit HIV spread between T cells.
Massanella M, Puigdomènech I, Cabrera C, Fernandez-Figueras MT, Aucher A, Gaibelet G, Hudrisier D, García E, Bofill M, Clotet B, Blanco J
AIDS 2009 Jan 14;23(2):183-8. doi: 10.1097/QAD.0b013e32831ef1a3. PMID: 19098487
Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1.
Liao Z, Cimakasky LM, Hampton R, Nguyen DH, Hildreth JE
AIDS Res Hum Retroviruses 2001 Jul 20;17(11):1009-19. doi: 10.1089/088922201300343690. PMID: 11485618

Therapy

The ubiquitin-proteasome system in HIV replication: potential targets for antiretroviral therapy.
Klinger PP, Schubert U
Expert Rev Anti Infect Ther 2005 Feb;3(1):61-79. doi: 10.1586/14787210.3.1.61. PMID: 15757458

Prognosis

Evidence that HIV budding in primary macrophages occurs through the exosome release pathway.
Nguyen DG, Booth A, Gould SJ, Hildreth JE
J Biol Chem 2003 Dec 26;278(52):52347-54. Epub 2003 Oct 14 doi: 10.1074/jbc.M309009200. PMID: 14561735

Clinical prediction guides

ESCRT-II functions by linking to ESCRT-I in human immunodeficiency virus-1 budding.
Meng B, Ip NCY, Abbink TEM, Kenyon JC, Lever AML
Cell Microbiol 2020 May;22(5):e13161. Epub 2020 Feb 14 doi: 10.1111/cmi.13161. PMID: 31922351Free PMC Article
The Race against Protease Activation Defines the Role of ESCRTs in HIV Budding.
Bendjennat M, Saffarian S
PLoS Pathog 2016 Jun;12(6):e1005657. Epub 2016 Jun 9 doi: 10.1371/journal.ppat.1005657. PMID: 27280284Free PMC Article
Structure of cellular ESCRT-III spirals and their relationship to HIV budding.
Cashikar AG, Shim S, Roth R, Maldazys MR, Heuser JE, Hanson PI
Elife 2014 May 30;3 doi: 10.7554/eLife.02184. PMID: 24878737Free PMC Article
Reactivation from latency displays HIV particle budding at plasma membrane, accompanying CD44 upregulation and recruitment.
Suyama M, Daikoku E, Goto T, Sano K, Morikawa Y
Retrovirology 2009 Jul 13;6:63. doi: 10.1186/1742-4690-6-63. PMID: 19594910Free PMC Article
The ubiquitin-proteasome system in HIV replication: potential targets for antiretroviral therapy.
Klinger PP, Schubert U
Expert Rev Anti Infect Ther 2005 Feb;3(1):61-79. doi: 10.1586/14787210.3.1.61. PMID: 15757458

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