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Elevated IgA (equal to or greater than 2.6g/L)

MedGen UID:
337948
•Concept ID:
C1850026
•
Finding

Professional guidelines

PubMed

Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies.
Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, Sanchez E, Chen H, Radigan L, Berenson J, Cunningham-Rundles C
J Allergy Clin Immunol Pract 2020 Jan;8(1):283-291.e1. Epub 2019 Aug 17 doi: 10.1016/j.jaip.2019.08.012. PMID: 31430592Free PMC Article
Cord blood IgE. I. IgE screening in 2814 newborn children.
Hansen LG, Høst A, Halken S, Holmskov A, Husby S, Lassen LB, Storm K, Osterballe O
Allergy 1992 Aug;47(4 Pt 2):391-6. doi: 10.1111/j.1398-9995.1992.tb02078.x. PMID: 1456410
Staphylococcal protein A adsorption of neonatal serum to facilitate early diagnosis of congenital infection.
Tuomanen EI, Powell KR
J Pediatr 1980 Aug;97(2):238-43. doi: 10.1016/s0022-3476(80)80481-1. PMID: 6249903

Recent clinical studies

Etiology

Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies.
Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, Sanchez E, Chen H, Radigan L, Berenson J, Cunningham-Rundles C
J Allergy Clin Immunol Pract 2020 Jan;8(1):283-291.e1. Epub 2019 Aug 17 doi: 10.1016/j.jaip.2019.08.012. PMID: 31430592Free PMC Article
Mortality of IgA nephropathy patients: a single center experience over 30 years.
Lee H, Kim DK, Oh KH, Joo KW, Kim YS, Chae DW, Kim S, Chin HJ
PLoS One 2012;7(12):e51225. Epub 2012 Dec 4 doi: 10.1371/journal.pone.0051225. PMID: 23226568Free PMC Article
Immunoglobulin A deficiency in celiac disease.
Chow MA, Lebwohl B, Reilly NR, Green PH
J Clin Gastroenterol 2012 Nov-Dec;46(10):850-4. doi: 10.1097/MCG.0b013e31824b2277. PMID: 22476042
Antigliadin antibodies in psoriasis.
Sultan SJ, Ahmad QM, Sultan ST
Australas J Dermatol 2010 Nov;51(4):238-42. doi: 10.1111/j.1440-0960.2010.00648.x. PMID: 21198518
Serum IgG and IgA antibodies to Chlamydia in ectopic pregnancies.
Chaim W, Sarov B, Sarov I, Piura B, Cohen A, Insler V
Contraception 1989 Jul;40(1):59-71. doi: 10.1016/0010-7824(89)90028-0. PMID: 2673659

Diagnosis

Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies.
Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, Sanchez E, Chen H, Radigan L, Berenson J, Cunningham-Rundles C
J Allergy Clin Immunol Pract 2020 Jan;8(1):283-291.e1. Epub 2019 Aug 17 doi: 10.1016/j.jaip.2019.08.012. PMID: 31430592Free PMC Article
Mortality of IgA nephropathy patients: a single center experience over 30 years.
Lee H, Kim DK, Oh KH, Joo KW, Kim YS, Chae DW, Kim S, Chin HJ
PLoS One 2012;7(12):e51225. Epub 2012 Dec 4 doi: 10.1371/journal.pone.0051225. PMID: 23226568Free PMC Article
A modern approach to CSF analysis: pathophysiology, clinical application, proof of concept and laboratory reporting.
Regeniter A, Kuhle J, Mehling M, Möller H, Wurster U, Freidank H, Siede WH
Clin Neurol Neurosurg 2009 May;111(4):313-8. Epub 2009 Jan 30 doi: 10.1016/j.clineuro.2008.12.004. PMID: 19185983
Clinical manifestations of IgE hypogammaglobulinemia.
Smith JK, Krishnaswamy GH, Dykes R, Reynolds S, Berk SL
Ann Allergy Asthma Immunol 1997 Mar;78(3):313-8. doi: 10.1016/S1081-1206(10)63188-2. PMID: 9087159
Serum IgG and IgA antibodies to Chlamydia in ectopic pregnancies.
Chaim W, Sarov B, Sarov I, Piura B, Cohen A, Insler V
Contraception 1989 Jul;40(1):59-71. doi: 10.1016/0010-7824(89)90028-0. PMID: 2673659

Therapy

Rapid Onset of Action in Patients With Moderate-to-Severe Plaque Psoriasis With Halobetasol 0.01%/Tazarotene 0.045% Fixed Combination.
Stein Gold L, Kircik LH, Pariser D, Sugarman JL, Lin T, Kang R, Pillai R
J Drugs Dermatol 2018 Aug 1;17(8):863-868. PMID: 30124725
Mortality of IgA nephropathy patients: a single center experience over 30 years.
Lee H, Kim DK, Oh KH, Joo KW, Kim YS, Chae DW, Kim S, Chin HJ
PLoS One 2012;7(12):e51225. Epub 2012 Dec 4 doi: 10.1371/journal.pone.0051225. PMID: 23226568Free PMC Article
Efficacy of auxiliary therapy with Danggui Buxue Decoction No.1 in treating patients of non-small cell lung cancer at peri-operational stage.
Du QC, Yang KZ, Sun XF
Chin J Integr Med 2009 Jun;15(3):184-8. Epub 2009 Jul 2 doi: 10.1007/s11655-009-0184-y. PMID: 19568710
Associations between plasma DDE levels and immunologic measures in African-American farmers in North Carolina.
Cooper GS, Martin SA, Longnecker MP, Sandler DP, Germolec DR
Environ Health Perspect 2004 Jul;112(10):1080-4. doi: 10.1289/ehp.6892. PMID: 15238281Free PMC Article
Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine.
Clements ML, Murphy BR
J Clin Microbiol 1986 Jan;23(1):66-72. doi: 10.1128/jcm.23.1.66-72.1986. PMID: 3700610Free PMC Article

Prognosis

Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies.
Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, Sanchez E, Chen H, Radigan L, Berenson J, Cunningham-Rundles C
J Allergy Clin Immunol Pract 2020 Jan;8(1):283-291.e1. Epub 2019 Aug 17 doi: 10.1016/j.jaip.2019.08.012. PMID: 31430592Free PMC Article
Rapid Onset of Action in Patients With Moderate-to-Severe Plaque Psoriasis With Halobetasol 0.01%/Tazarotene 0.045% Fixed Combination.
Stein Gold L, Kircik LH, Pariser D, Sugarman JL, Lin T, Kang R, Pillai R
J Drugs Dermatol 2018 Aug 1;17(8):863-868. PMID: 30124725
Seroprevalence of IgA anti Epstein-Barr virus is high among family members of nasopharyngeal cancer patients and individuals presenting with chronic complaints in head and neck area.
Hutajulu SH, Fachiroh J, Argy G, Indrasari SR, Indrawati LPL, Paramita DK, Jati TBR, Middeldorp JM
PLoS One 2017;12(8):e0180683. Epub 2017 Aug 11 doi: 10.1371/journal.pone.0180683. PMID: 28800616Free PMC Article
Impact of Body Mass Index on Progression of IgA Nephropathy Among Japanese Patients.
Shimamoto M, Ohsawa I, Suzuki H, Hisada A, Nagamachi S, Honda D, Inoshita H, Shimizu Y, Horikoshi S, Tomino Y
J Clin Lab Anal 2015 Sep;29(5):353-60. Epub 2014 Aug 17 doi: 10.1002/jcla.21778. PMID: 25131157Free PMC Article
Mortality of IgA nephropathy patients: a single center experience over 30 years.
Lee H, Kim DK, Oh KH, Joo KW, Kim YS, Chae DW, Kim S, Chin HJ
PLoS One 2012;7(12):e51225. Epub 2012 Dec 4 doi: 10.1371/journal.pone.0051225. PMID: 23226568Free PMC Article

Clinical prediction guides

Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies.
Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, Sanchez E, Chen H, Radigan L, Berenson J, Cunningham-Rundles C
J Allergy Clin Immunol Pract 2020 Jan;8(1):283-291.e1. Epub 2019 Aug 17 doi: 10.1016/j.jaip.2019.08.012. PMID: 31430592Free PMC Article
Seroprevalence of IgA anti Epstein-Barr virus is high among family members of nasopharyngeal cancer patients and individuals presenting with chronic complaints in head and neck area.
Hutajulu SH, Fachiroh J, Argy G, Indrasari SR, Indrawati LPL, Paramita DK, Jati TBR, Middeldorp JM
PLoS One 2017;12(8):e0180683. Epub 2017 Aug 11 doi: 10.1371/journal.pone.0180683. PMID: 28800616Free PMC Article
Impact of Body Mass Index on Progression of IgA Nephropathy Among Japanese Patients.
Shimamoto M, Ohsawa I, Suzuki H, Hisada A, Nagamachi S, Honda D, Inoshita H, Shimizu Y, Horikoshi S, Tomino Y
J Clin Lab Anal 2015 Sep;29(5):353-60. Epub 2014 Aug 17 doi: 10.1002/jcla.21778. PMID: 25131157Free PMC Article
Antigliadin antibodies in psoriasis.
Sultan SJ, Ahmad QM, Sultan ST
Australas J Dermatol 2010 Nov;51(4):238-42. doi: 10.1111/j.1440-0960.2010.00648.x. PMID: 21198518
Endothelin 1 levels in relation to clinical presentation and outcome of Henoch Schonlein purpura.
Fessatou S, Nicolaidou P, Gourgiotis D, Georgouli H, Douros K, Moustaki M, Fretzayas A
BMC Pediatr 2008 Sep 2;8:33. doi: 10.1186/1471-2431-8-33. PMID: 18764935Free PMC Article

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