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  • The following terms were not found in MedGen: I9, Cyrillicsmall, Cyrillic.

Generalized eruptive keratoacanthoma

MedGen UID:
577226
•Concept ID:
C0345985
•
Neoplastic Process
Synonyms: Eruptive keratoacanthoma; GEKA; generalised eruptive keratoacanthomas of Grzybowski; generalized eruptive keratoacanthoma; Generalized eruptive keratoacanthomas of Grzybowski; generalized eruptive keratoacanthomas of Grzybowski; Grzybowski syndrome
SNOMED CT: Eruptive keratoacanthoma (254664008); Generalized eruptive keratoacanthoma (254664008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018471
Orphanet: ORPHA411777

Definition

Generalized eruptive keratoacanthoma (GEKA) is rare variant of keratoacanthoma (KA) that affects the skin and mucous membranes and which is characterized by a sudden generalized eruption of severely pruritic, hundreds to thousands of small follicular papules, often with a central keratotic plug. [from ORDO]

Professional guidelines

PubMed

Two birds with one stone: Successful treatment with methotrexate in a patient with generalized eruptive keratoacanthoma of Grzybowski and rheumatoid arthritis.
Filippi F, Carpanese MA, Sacchelli L, Loi C, Chessa MA, Bardazzi F
Dermatol Ther 2022 Nov;35(11):e15787. Epub 2022 Sep 9 doi: 10.1111/dth.15787. PMID: 36018509Free PMC Article
Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation.
Nofal A, Assaf M, Nofal E, Alradi M
J Eur Acad Dermatol Venereol 2014 Apr;28(4):397-404. Epub 2013 Aug 6 doi: 10.1111/jdv.12226. PMID: 23919932
Generalized eruptive keratoacanthoma of Grzybowski: strict diagnostic criteria are still lacking.
Nofal A, Nofal E
Clin Exp Dermatol 2014 Jan;39(1):87-8. Epub 2013 Jun 14 doi: 10.1111/ced.12178. PMID: 23763566

Recent clinical studies

Etiology

Generalized eruptive keratoacanthoma of Grzybowski: follow-up of the original description and 50-year retrospect.
Schwartz RA, Błaszczyk M, Jablonska S
Dermatology 2002;205(4):348-52. doi: 10.1159/000066422. PMID: 12444329
Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus.
Haas N, Schadendorf D, Henz BM, Fuchs PG
Br J Dermatol 2002 Oct;147(4):793-6. doi: 10.1046/j.1365-2133.2002.04925.x. PMID: 12366433

Diagnosis

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review.
Xu Q, Li C, Zhang J, Ling B, Yu H, Yao Z
J Dermatol 2018 Feb;45(2):211-215. Epub 2017 Oct 23 doi: 10.1111/1346-8138.14106. PMID: 29058335
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge.
Nofal A, Assaf M, Ghonemy S, Nofal E, Yosef A
Int J Dermatol 2015 Feb;54(2):160-7. Epub 2014 Jul 29 doi: 10.1111/ijd.12308. PMID: 25070745
Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation.
Nofal A, Assaf M, Nofal E, Alradi M
J Eur Acad Dermatol Venereol 2014 Apr;28(4):397-404. Epub 2013 Aug 6 doi: 10.1111/jdv.12226. PMID: 23919932
Generalized eruptive keratoacanthomas.
Chu DH, Hale EK, Robins P
Dermatol Online J 2003 Oct;9(4):36. PMID: 14594609
Generalized eruptive keratoacanthoma.
Young SK, Larsen PE, Markowitz NR
Oral Surg Oral Med Oral Pathol 1986 Oct;62(4):422-6. doi: 10.1016/0030-4220(86)90292-6. PMID: 3464915

Therapy

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review.
Xu Q, Li C, Zhang J, Ling B, Yu H, Yao Z
J Dermatol 2018 Feb;45(2):211-215. Epub 2017 Oct 23 doi: 10.1111/1346-8138.14106. PMID: 29058335
Generalized eruptive keratoacanthoma of Grzybowski.
Chowdhury S, Bandyopadhyay D, Mondal AK
Skinmed 2015 Mar-Apr;13(2):148-50. PMID: 26137745
Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge.
Nofal A, Assaf M, Ghonemy S, Nofal E, Yosef A
Int J Dermatol 2015 Feb;54(2):160-7. Epub 2014 Jul 29 doi: 10.1111/ijd.12308. PMID: 25070745
Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation.
Nofal A, Assaf M, Nofal E, Alradi M
J Eur Acad Dermatol Venereol 2014 Apr;28(4):397-404. Epub 2013 Aug 6 doi: 10.1111/jdv.12226. PMID: 23919932
Generalized eruptive keratoacanthoma (Grzybowski variant).
Consigli JE, González ME, Morsino R, Guidi A, Chappuis JM, Papa M, Maldonado S
Br J Dermatol 2000 Apr;142(4):800-3. doi: 10.1046/j.1365-2133.2000.03430.x. PMID: 10792236

Prognosis

Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation.
Nofal A, Assaf M, Nofal E, Alradi M
J Eur Acad Dermatol Venereol 2014 Apr;28(4):397-404. Epub 2013 Aug 6 doi: 10.1111/jdv.12226. PMID: 23919932
Generalized eruptive keratoacanthomas.
Chu DH, Hale EK, Robins P
Dermatol Online J 2003 Oct;9(4):36. PMID: 14594609
Generalized eruptive keratoacanthoma of Grzybowski: follow-up of the original description and 50-year retrospect.
Schwartz RA, Błaszczyk M, Jablonska S
Dermatology 2002;205(4):348-52. doi: 10.1159/000066422. PMID: 12444329
Generalized eruptive keratoacanthoma (Grzybowski variant).
Consigli JE, González ME, Morsino R, Guidi A, Chappuis JM, Papa M, Maldonado S
Br J Dermatol 2000 Apr;142(4):800-3. doi: 10.1046/j.1365-2133.2000.03430.x. PMID: 10792236
Generalized eruptive keratoacanthoma of Grzybowski.
Jaber PW, Cooper PH, Greer KE
J Am Acad Dermatol 1993 Aug;29(2 Pt 2):299-304. doi: 10.1016/0190-9622(93)70180-2. PMID: 8340502

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