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  • The following term was not found in MedGen: Hexamethylenediammonium.

Isosorbide dinitrate response

MedGen UID:
450462
•Concept ID:
CN077990
•
Sign or Symptom
Synonyms: Isordil response; Isordil titradose response; Isosorbide response
Drug:
Isosorbide dinitrate
MedGen UID:
9581
•Concept ID:
C0022251
•
Pharmacologic Substance
An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. [from NCI]
Isosorbide dinitrate

Professional guidelines

PubMed

A Systematic Review and Network Meta-Analysis of Pharmacological Treatment of Heart Failure With Reduced Ejection Fraction.
Tromp J, Ouwerkerk W, van Veldhuisen DJ, Hillege HL, Richards AM, van der Meer P, Anand IS, Lam CSP, Voors AA
JACC Heart Fail 2022 Feb;10(2):73-84. Epub 2021 Dec 8 doi: 10.1016/j.jchf.2021.09.004. PMID: 34895860
Combination of Hydralazine and Isosorbide-Dinitrate in the Treatment of Patients with Heart Failure with Reduced Ejection Fraction.
Nyolczas N, Dékány M, Muk B, Szabó B
Adv Exp Med Biol 2018;1067:31-45. doi: 10.1007/5584_2017_112. PMID: 29086392
New Management Strategies in Heart Failure.
Owens AT, Brozena SC, Jessup M
Circ Res 2016 Feb 5;118(3):480-95. doi: 10.1161/CIRCRESAHA.115.306567. PMID: 26846642

Curated

DailyMed Drug Label, ISOSORBIDE DINITRATE tablet, 2021

Recent clinical studies

Etiology

Pediatric patients' head-up-tilt-test with pharmacological challenge, it is safe?
García A, Bustillos-García GA, Rivera-Roodríguez L
Arch Cardiol Mex 2020;90(2):163-172. doi: 10.24875/ACME.M20000111. PMID: 32897267
Pediatrics patients head-up tilt test with pharmacological challenge, it is safe?
García A, Bustillos-García GA, Rivera-Rodríguez L
Arch Cardiol Mex 2020;90(2):178-188. doi: 10.24875/ACM.19000260. PMID: 32459207
Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial.
Ferdinand KC, Elkayam U, Mancini D, Ofili E, Piña I, Anand I, Feldman AM, McNamara D, Leggett C
Am J Cardiol 2014 Jul 1;114(1):151-9. Epub 2014 Apr 18 doi: 10.1016/j.amjcard.2014.04.018. PMID: 24846808
A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination.
Cheng JW
Clin Ther 2006 May;28(5):666-78. doi: 10.1016/j.clinthera.2006.05.007. PMID: 16861089
Combination of isosorbide dinitrate and hydralazine in blacks with heart failure.
Taylor AL, Ziesche S, Yancy C, Carson P, D'Agostino R Jr, Ferdinand K, Taylor M, Adams K, Sabolinski M, Worcel M, Cohn JN; African-American Heart Failure Trial Investigators
N Engl J Med 2004 Nov 11;351(20):2049-57. Epub 2004 Nov 8 doi: 10.1056/NEJMoa042934. PMID: 15533851

Diagnosis

Achieving Optimal Medical Therapy: Insights From the ORBITA Trial.
Foley M, Rajkumar CA, Shun-Shin M, Ganesananthan S, Seligman H, Howard J, Nowbar AN, Keeble TR, Davies JR, Tang KH, Gerber R, O'Kane P, Sharp ASP, Petraco R, Malik IS, Nijjer S, Sen S, Francis DP, Al-Lamee R
J Am Heart Assoc 2021 Feb 2;10(3):e017381. Epub 2021 Jan 26 doi: 10.1161/JAHA.120.017381. PMID: 33496201Free PMC Article
Pediatric patients' head-up-tilt-test with pharmacological challenge, it is safe?
García A, Bustillos-García GA, Rivera-Roodríguez L
Arch Cardiol Mex 2020;90(2):163-172. doi: 10.24875/ACME.M20000111. PMID: 32897267
Pediatrics patients head-up tilt test with pharmacological challenge, it is safe?
García A, Bustillos-García GA, Rivera-Rodríguez L
Arch Cardiol Mex 2020;90(2):178-188. doi: 10.24875/ACM.19000260. PMID: 32459207
Isoprenaline versus nitroglycerine in head-up tilt test.
Bilagi UR, Shenthar J, Cholenahally MN
Indian Heart J 2017 Jan-Feb;69(1):48-51. Epub 2016 Jun 20 doi: 10.1016/j.ihj.2016.06.007. PMID: 28228306Free PMC Article
Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation.
Gelfond M, Rozen P, Gilat T
Gastroenterology 1982 Nov;83(5):963-9. PMID: 6288509

Therapy

Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress.
Daiber A, Münzel T
Antioxid Redox Signal 2015 Oct 10;23(11):899-942. Epub 2015 Sep 24 doi: 10.1089/ars.2015.6376. PMID: 26261901Free PMC Article
Combination of isosorbide dinitrate and hydralazine in blacks with heart failure.
Taylor AL, Ziesche S, Yancy C, Carson P, D'Agostino R Jr, Ferdinand K, Taylor M, Adams K, Sabolinski M, Worcel M, Cohn JN; African-American Heart Failure Trial Investigators
N Engl J Med 2004 Nov 11;351(20):2049-57. Epub 2004 Nov 8 doi: 10.1056/NEJMoa042934. PMID: 15533851
Long-acting isosorbide mononitrate.
Prakash A, Markham A
Drugs 1999 Jan;57(1):93-9; discussion 100. doi: 10.2165/00003495-199957010-00008. PMID: 9951954
Nitrates.
Kuhn M
AACN Clin Issues Crit Care Nurs 1992 May;3(2):409-22. doi: 10.4037/15597768-1992-2013. PMID: 1576038
High-dosage isosorbide dinitrate therapy for angina.
Tremblay G, Biron P, Désourdy F
Can Med Assoc J 1983 Mar 15;128(6):679-81. PMID: 6825033Free PMC Article

Prognosis

Achieving Optimal Medical Therapy: Insights From the ORBITA Trial.
Foley M, Rajkumar CA, Shun-Shin M, Ganesananthan S, Seligman H, Howard J, Nowbar AN, Keeble TR, Davies JR, Tang KH, Gerber R, O'Kane P, Sharp ASP, Petraco R, Malik IS, Nijjer S, Sen S, Francis DP, Al-Lamee R
J Am Heart Assoc 2021 Feb 2;10(3):e017381. Epub 2021 Jan 26 doi: 10.1161/JAHA.120.017381. PMID: 33496201Free PMC Article
Future of personalized pharmacotherapy in chronic heart failure patients.
Norgard NB, Prescott GM
Future Cardiol 2011 May;7(3):357-79. doi: 10.2217/fca.11.19. PMID: 21627477
The African American Heart Failure Trial: a clinical trial update.
Taylor AL
Am J Cardiol 2005 Oct 10;96(7B):44-8. Epub 2005 Aug 9 doi: 10.1016/j.amjcard.2005.07.033. PMID: 16226935
A systematic review of medical therapy for anal fissure.
Nelson R
Dis Colon Rectum 2004 Apr;47(4):422-31. Epub 2004 Mar 4 doi: 10.1007/s10350-003-0079-5. PMID: 14994109
Isosorbide dinitrate and nifedipine in variant angina pectoris.
Conti CR, Hill JA, Feldman RL, Conti JB, Pepine CJ
Am Heart J 1985 Jul;110(1 Pt 2):251-6. doi: 10.1016/0002-8703(85)90495-8. PMID: 3925744

Clinical prediction guides

Future of personalized pharmacotherapy in chronic heart failure patients.
Norgard NB, Prescott GM
Future Cardiol 2011 May;7(3):357-79. doi: 10.2217/fca.11.19. PMID: 21627477
A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination.
Cheng JW
Clin Ther 2006 May;28(5):666-78. doi: 10.1016/j.clinthera.2006.05.007. PMID: 16861089
Combination of isosorbide dinitrate and hydralazine in blacks with heart failure.
Taylor AL, Ziesche S, Yancy C, Carson P, D'Agostino R Jr, Ferdinand K, Taylor M, Adams K, Sabolinski M, Worcel M, Cohn JN; African-American Heart Failure Trial Investigators
N Engl J Med 2004 Nov 11;351(20):2049-57. Epub 2004 Nov 8 doi: 10.1056/NEJMoa042934. PMID: 15533851
Long-acting isosorbide mononitrate.
Prakash A, Markham A
Drugs 1999 Jan;57(1):93-9; discussion 100. doi: 10.2165/00003495-199957010-00008. PMID: 9951954
Isosorbide dinitrate and nifedipine in variant angina pectoris.
Conti CR, Hill JA, Feldman RL, Conti JB, Pepine CJ
Am Heart J 1985 Jul;110(1 Pt 2):251-6. doi: 10.1016/0002-8703(85)90495-8. PMID: 3925744

Recent systematic reviews

A systematic review of medical therapy for anal fissure.
Nelson R
Dis Colon Rectum 2004 Apr;47(4):422-31. Epub 2004 Mar 4 doi: 10.1007/s10350-003-0079-5. PMID: 14994109

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