Kluver-Bucy syndrome

MedGen UID:: 124361
•Concept ID:: C0270707
•: Mental or Behavioral Dysfunction

Synonyms:	Bilateral temporal lobe disorder; Memory loss, extreme sexual behavior, placidity, and visual distractibility; Post-encephalitic Kluver Bucy syndrome (type); Post-traumatic Kluver Bucy syndrome (type)
SNOMED CT:	Klüver-Bucy syndrome (10651001)

Monarch Initiative:	MONDO:0005817
Orphanet:	ORPHA157823

Definition

A rare neurologic disease characterized by visual agnosia, hyperorality (strong tendency to examine objects orally), hypermetamorphosis (described as the irresistible impulse to notice and react to everything within sight), hypersexuality, changes in dietary habits and hyperphagia, placidity, and amnesia, due to bilateral lesions of the temporal lobe including the hippocampus and amygdala. [from ORDO]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVKluver-Bucy syndrome

Disease
- Disorder by Site
  - Disorder of nervous system
    - Disorder of the central nervous system
      - Brain disorder
        Dementia
        Kluver-Bucy syndrome

Follow this link to review classifications for Kluver-Bucy syndrome in Orphanet.

Professional guidelines

PubMed

Klüver-Bucy Syndrome Following Traumatic Brain Injury: A Systematic Synthesis and Review of Pharmacological Treatment From Cases in Adolescents and Adults.

Clay FJ, Kuriakose A, Lesche D, Hicks AJ, Zaman H, Azizi E, Ponsford JL, Jayaram M, Hopwood M
J Neuropsychiatry Clin Neurosci 2019 Winter;31(1):6-16. Epub 2018 Oct 31 doi: 10.1176/appi.neuropsych.18050112. PMID: 30376788

Neuropsychiatric features of frontotemporal dementia: evaluation of consensus criteria and review.

Mendez MF, Perryman KM
J Neuropsychiatry Clin Neurosci 2002 Fall;14(4):424-9. doi: 10.1176/jnp.14.4.424. PMID: 12426410

Klüver-Bucy syndrome. Successful treatment with carbamazepine.

Hooshmand H, Sepdham T, Vries JK
JAMA 1974 Sep 23;229(13):1782. PMID: 4479148

See all (3)

Recent clinical studies

Therapy

Partial Kluver-Bucy syndrome secondary to tubercular meningitis.

Jha KK, Singh SK, Kumar P, Arora CD
BMJ Case Rep 2016 Aug 16;2016 doi: 10.1136/bcr-2016-215926. PMID: 27530874 Free PMC Article

Kluver-Bucy syndrome, hypersexuality, and the law.

Devinsky J, Sacks O, Devinsky O
Neurocase 2010 Apr;16(2):140-5. Epub 2009 Nov 18 doi: 10.1080/13554790903329182. PMID: 19927260

Mycoplasma pneumoniae central nervous system infections.

Daxboeck F
Curr Opin Neurol 2006 Aug;19(4):374-8. doi: 10.1097/01.wco.0000236617.04958.60. PMID: 16914976

Kluver-Bucy syndrome after mycoplasmal bronchitis.

Auvichayapat N, Auvichayapat P, Watanatorn J, Thamaroj J, Jitpimolmard S
Epilepsy Behav 2006 Feb;8(1):320-2. Epub 2005 Dec 13 doi: 10.1016/j.yebeh.2005.10.005. PMID: 16356778

Neuroleptic-induced Klüver-Bucy syndrome.

Varga E, Haher EJ, Simpson GM
Biol Psychiatry 1975 Feb;10(1):65-8. PMID: 235332

See all (39)

Prognosis

Klüver-Bucy syndrome secondary to a nondominant middle cerebral artery ischemic stroke: a case report and review of the literature.

Al-Attas AA, Aldayel AY, Aloufi TH, Biary N
J Med Case Rep 2021 Jul 15;15(1):346. doi: 10.1186/s13256-021-02932-0. PMID: 34261516 Free PMC Article

Mesiotemporal Disconnection and Hypoactivity in Klüver-Bucy Syndrome: Case Series and Literature Review.

Caro MA, Jimenez XF
J Clin Psychiatry 2016 Aug;77(8):e982-8. doi: 10.4088/JCP.14r09497. PMID: 27380585

The neuropsychiatry of Parkinson's disease and related disorders.

Lauterbach EC
Psychiatr Clin North Am 2004 Dec;27(4):801-25. doi: 10.1016/j.psc.2004.07.001. PMID: 15550293

Excessive masturbation after epilepsy surgery.

Ozmen M, Erdogan A, Duvenci S, Ozyurt E, Ozkara C
Epilepsy Behav 2004 Feb;5(1):133-6. doi: 10.1016/j.yebeh.2003.10.009. PMID: 14751219

Familial progressive subcortical gliosis.

Lanska DJ, Currier RD, Cohen M, Gambetti P, Smith EE, Bebin J, Jackson JF, Whitehouse PJ, Markesbery WR
Neurology 1994 Sep;44(9):1633-43. doi: 10.1212/wnl.44.9.1633. PMID: 7936288

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