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  • The following terms were not found in MedGen: opsmall, Cyrillicopopop.

Weak C phenotype

MedGen UID:
552899
•Concept ID:
C0312949
•
Finding
Synonym: Blood group antigen C^u^
SNOMED CT: Weak C phenotype (3067005); Blood group antigen C^u^ (3067005)

Professional guidelines

PubMed

Variant genotypes associated with reduced expression of RhCE antigens among Brazilian blood donors.
Dezan MR, Oliveira VB, Conrado MCAV, da Rocha MC, Luz F, Gallucci A, Pereira AC, Krieger JE, Rocha V, Mendrone-Junior A, Dinardo CL
Transfusion 2021 Jun;61(6):1923-1931. Epub 2021 Mar 9 doi: 10.1111/trf.16355. PMID: 33687082

Recent clinical studies

Etiology

Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient.
Prado CM, Ford KL, Gonzalez MC, Murnane LC, Gillis C, Wischmeyer PE, Morrison CA, Lobo DN
JPEN J Parenter Enteral Nutr 2023 Feb;47 Suppl 1(Suppl 1):S54-S68. Epub 2022 Dec 5 doi: 10.1002/jpen.2420. PMID: 36468288Free PMC Article
The senescence-associated secretome as an indicator of age and medical risk.
Schafer MJ, Zhang X, Kumar A, Atkinson EJ, Zhu Y, Jachim S, Mazula DL, Brown AK, Berning M, Aversa Z, Kotajarvi B, Bruce CJ, Greason KL, Suri RM, Tracy RP, Cummings SR, White TA, LeBrasseur NK
JCI Insight 2020 Jun 18;5(12) doi: 10.1172/jci.insight.133668. PMID: 32554926Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Mendelian randomization analysis with multiple genetic variants using summarized data.
Burgess S, Butterworth A, Thompson SG
Genet Epidemiol 2013 Nov;37(7):658-65. Epub 2013 Sep 20 doi: 10.1002/gepi.21758. PMID: 24114802Free PMC Article
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Deslattes Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science 2001 Feb 16;291(5507):1304-51. doi: 10.1126/science.1058040. PMID: 11181995

Diagnosis

Can geroscience be translated into healthcare?
Ferrucci L, Tanaka T, Polidori MC
Z Gerontol Geriatr 2024 Aug;57(5):349-354. Epub 2024 Jul 9 doi: 10.1007/s00391-024-02326-z. PMID: 38981884Free PMC Article
Genetic liability to frailty in relation to functional outcome after ischemic stroke.
Cai H, Zhang H, Liang J, Liu Z, Huang G
Int J Stroke 2024 Jan;19(1):50-57. Epub 2023 Aug 22 doi: 10.1177/17474930231194676. PMID: 37542426
Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient.
Prado CM, Ford KL, Gonzalez MC, Murnane LC, Gillis C, Wischmeyer PE, Morrison CA, Lobo DN
JPEN J Parenter Enteral Nutr 2023 Feb;47 Suppl 1(Suppl 1):S54-S68. Epub 2022 Dec 5 doi: 10.1002/jpen.2420. PMID: 36468288Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Avoiding bias from weak instruments in Mendelian randomization studies.
Burgess S, Thompson SG; CRP CHD Genetics Collaboration
Int J Epidemiol 2011 Jun;40(3):755-64. Epub 2011 Mar 16 doi: 10.1093/ije/dyr036. PMID: 21414999

Therapy

Correlations in sleeping patterns and circadian preference between spouses.
Richmond RC, Howe LJ, Heilbron K, Jones S, Liu J; 23andMe Research Team, Wang X, Weedon MN, Rutter MK, Lawlor DA, Davey Smith G, Vetter C
Commun Biol 2023 Nov 13;6(1):1156. doi: 10.1038/s42003-023-05521-7. PMID: 37957254Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Mendelian randomization analysis with multiple genetic variants using summarized data.
Burgess S, Butterworth A, Thompson SG
Genet Epidemiol 2013 Nov;37(7):658-65. Epub 2013 Sep 20 doi: 10.1002/gepi.21758. PMID: 24114802Free PMC Article
Avoiding bias from weak instruments in Mendelian randomization studies.
Burgess S, Thompson SG; CRP CHD Genetics Collaboration
Int J Epidemiol 2011 Jun;40(3):755-64. Epub 2011 Mar 16 doi: 10.1093/ije/dyr036. PMID: 21414999
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Deslattes Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science 2001 Feb 16;291(5507):1304-51. doi: 10.1126/science.1058040. PMID: 11181995

Prognosis

FUT1 variants responsible for Bombay or para-Bombay phenotypes in a database.
Soejima M, Koda Y
Sci Rep 2023 Oct 14;13(1):17447. doi: 10.1038/s41598-023-44731-1. PMID: 37838738Free PMC Article
Transcriptomic reprogramming for neuronal age reversal.
Plesa AM, Shadpour M, Boyden E, Church GM
Hum Genet 2023 Aug;142(8):1293-1302. Epub 2023 Apr 1 doi: 10.1007/s00439-023-02529-1. PMID: 37004545Free PMC Article
Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient.
Prado CM, Ford KL, Gonzalez MC, Murnane LC, Gillis C, Wischmeyer PE, Morrison CA, Lobo DN
JPEN J Parenter Enteral Nutr 2023 Feb;47 Suppl 1(Suppl 1):S54-S68. Epub 2022 Dec 5 doi: 10.1002/jpen.2420. PMID: 36468288Free PMC Article
The senescence-associated secretome as an indicator of age and medical risk.
Schafer MJ, Zhang X, Kumar A, Atkinson EJ, Zhu Y, Jachim S, Mazula DL, Brown AK, Berning M, Aversa Z, Kotajarvi B, Bruce CJ, Greason KL, Suri RM, Tracy RP, Cummings SR, White TA, LeBrasseur NK
JCI Insight 2020 Jun 18;5(12) doi: 10.1172/jci.insight.133668. PMID: 32554926Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196

Clinical prediction guides

Correlations in sleeping patterns and circadian preference between spouses.
Richmond RC, Howe LJ, Heilbron K, Jones S, Liu J; 23andMe Research Team, Wang X, Weedon MN, Rutter MK, Lawlor DA, Davey Smith G, Vetter C
Commun Biol 2023 Nov 13;6(1):1156. doi: 10.1038/s42003-023-05521-7. PMID: 37957254Free PMC Article
Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient.
Prado CM, Ford KL, Gonzalez MC, Murnane LC, Gillis C, Wischmeyer PE, Morrison CA, Lobo DN
JPEN J Parenter Enteral Nutr 2023 Feb;47 Suppl 1(Suppl 1):S54-S68. Epub 2022 Dec 5 doi: 10.1002/jpen.2420. PMID: 36468288Free PMC Article
The senescence-associated secretome as an indicator of age and medical risk.
Schafer MJ, Zhang X, Kumar A, Atkinson EJ, Zhu Y, Jachim S, Mazula DL, Brown AK, Berning M, Aversa Z, Kotajarvi B, Bruce CJ, Greason KL, Suri RM, Tracy RP, Cummings SR, White TA, LeBrasseur NK
JCI Insight 2020 Jun 18;5(12) doi: 10.1172/jci.insight.133668. PMID: 32554926Free PMC Article
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Avoiding bias from weak instruments in Mendelian randomization studies.
Burgess S, Thompson SG; CRP CHD Genetics Collaboration
Int J Epidemiol 2011 Jun;40(3):755-64. Epub 2011 Mar 16 doi: 10.1093/ije/dyr036. PMID: 21414999

Recent systematic reviews

Left ventricular global longitudinal strain and cardiorespiratory fitness in patients with heart failure: Systematic review and meta-analysis.
D'Ávila LBO, Lima ACGB, Milani M, Milani JGPO, Cipriano GFB, Le Bihan DCS, Castro I, Cipriano G Jr
Hellenic J Cardiol 2024 Sep-Oct;79:58-69. Epub 2023 Sep 29 doi: 10.1016/j.hjc.2023.09.010. PMID: 37778639
The influence of thin as compared to thick peri-implant soft tissues on aesthetic outcomes: A systematic review and meta-analysis.
Bienz SP, Pirc M, Papageorgiou SN, Jung RE, Thoma DS
Clin Oral Implants Res 2022 Jun;33 Suppl 23(Suppl 23):56-71. doi: 10.1111/clr.13789. PMID: 35763024Free PMC Article
A Systematic Review and Meta-analysis of Animal Studies Investigating the Relationship Between Serum Antibody, T Lymphocytes, and Respiratory Syncytial Virus Disease.
McGinley J, Thwaites R, Brebner W, Greenan-Barrett L, Aerssens J, Öner D, Bont L, Wildenbeest J, Martinón-Torres F, Nair H, Pollard AJ, Openshaw P, Drysdale S; REspiratory Syncytial virus Consortium in EUrope (RESCEU) Investigators
J Infect Dis 2022 Aug 12;226(Suppl 1):S117-S129. doi: 10.1093/infdis/jiab370. PMID: 34522970
Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis.
Marcos-Pérez D, Sánchez-Flores M, Proietti S, Bonassi S, Costa S, Teixeira JP, Fernández-Tajes J, Pásaro E, Laffon B, Valdiglesias V
Geroscience 2020 Dec;42(6):1451-1473. Epub 2020 Aug 15 doi: 10.1007/s11357-020-00247-4. PMID: 32803650Free PMC Article
Prevalence of Frailty in Brazilian Older Adults: A Systematic Review and Meta-analysis.
Melo RC, Cipolli GC, Buarque GLA, Yassuda MS, Cesari M, Oude Voshaar RC, Aprahamian I
J Nutr Health Aging 2020;24(7):708-716. doi: 10.1007/s12603-020-1398-0. PMID: 32744566

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