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Phenytoin toxicity

MedGen UID:
101775
•Concept ID:
C0149969
•
Injury or Poisoning
Synonyms: ARENE OXIDE DETOXIFICATION DEFECT; Diphenylhydantoin, defect in hydroxylation of
 
Monarch Initiative: MONDO:0060690
OMIM®: 617955

Professional guidelines

PubMed

CYP2C9, CYP2C19, and ABCB1 genotype and hospitalization for phenytoin toxicity.
Hennessy S, Leonard CE, Freeman CP, Metlay JP, Chu X, Strom BL, Bilker WB
J Clin Pharmacol 2009 Dec;49(12):1483-7. Epub 2009 Jul 17 doi: 10.1177/0091270009343006. PMID: 19617466Free PMC Article
High-dose monotherapy in treatment of intractable seizures.
Lesser RP, Pippenger CE, Lüders H, Dinner DS
Neurology 1984 Jun;34(6):707-11. doi: 10.1212/wnl.34.6.707. PMID: 6539430

Recent systematic reviews

A systematic review of phenytoin intoxication induced by compound phenytoin sodium, ephedrine hydrochloride and theophylline tablets in China.
Zhang L, Li Z, Ma G, Han X, Li C, Shan M, Chen L
Medicine (Baltimore) 2018 Dec;97(51):e13689. doi: 10.1097/MD.0000000000013689. PMID: 30572493Free PMC Article

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