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7/8 HLA Match

MedGen UID:
1681132
•Concept ID:
C4764003
•
Finding
Synonym: HLA Match 7/8

Definition

Degree of HLA Match is 7/8 alleles with a single HLA locus mismatch at HLA-A, -B, -C or DRB1. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGV7/8 HLA Match

Professional guidelines

PubMed

Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis.
Bachanova V, Weisdorf DJ, Wang T, Marsh SGE, Cereb N, Haagenson MD, Spellman SR, Lee SJ, Guethlein LA, Parham P, Miller JS, Cooley SA
Biol Blood Marrow Transplant 2019 May;25(5):949-954. Epub 2018 Dec 27 doi: 10.1016/j.bbmt.2018.12.763. PMID: 30594542Free PMC Article
Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controls.
Yan G, Shi L, Fu Y, Wang X, Schoenfeld D, Ma L, Penfornis A, Gebel H, Faustman DL
Tissue Antigens 1997 Dec;50(6):576-85. doi: 10.1111/j.1399-0039.1997.tb02915.x. PMID: 9458110

Recent clinical studies

Etiology

Human leukocyte antigen compatibility and incidence of donor-specific antibodies in pediatric liver transplant recipients.
Melere MU, Feier FH, Neumann J, Kalil AN, Montagner JM, Nader LS, da Silva CS, Junior MAF, Coral GP, Bobsin GP, Ferreira CT
World J Gastroenterol 2024 Sep 7;30(33):3837-3845. doi: 10.3748/wjg.v30.i33.3837. PMID: 39351427Free PMC Article

Therapy

Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis.
Bolaños-Meade J, Hamadani M, Wu J, Al Malki MM, Martens MJ, Runaas L, Elmariah H, Rezvani AR, Gooptu M, Larkin KT, Shaffer BC, El Jurdi N, Loren AW, Solh M, Hall AC, Alousi AM, Jamy OH, Perales MA, Yao JM, Applegate K, Bhatt AS, Kean LS, Efebera YA, Reshef R, Clark W, DiFronzo NL, Leifer E, Horowitz MM, Jones RJ, Holtan SG; BMT CTN 1703 Investigators
N Engl J Med 2023 Jun 22;388(25):2338-2348. doi: 10.1056/NEJMoa2215943. PMID: 37342922Free PMC Article
Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia.
Wieduwilt MJ, Metheny L, Zhang MJ, Wang HL, Estrada-Merly N, Marks DI, Al-Homsi AS, Muffly L, Chao N, Rizzieri D, Gale RP, Gadalla SM, Cairo M, Mussetti A, Gore S, Bhatt VR, Patel SS, Michelis FV, Inamoto Y, Badawy SM, Copelan E, Palmisiano N, Kharfan-Dabaja MA, Lazarus HM, Ganguly S, Bredeson C, Diaz Perez MA, Cassaday R, Savani BN, Ballen K, Martino R, Wirk B, Bacher U, Aljurf M, Bashey A, Murthy HS, Yared JA, Aldoss I, Farhadfar N, Liu H, Abdel-Azim H, Waller EK, Solh M, Seftel MD, van der Poel M, Grunwald MR, Liesveld JL, Kamble RT, McGuirk J, Munker R, Cahn JY, Lee JW, Freytes CO, Krem MM, Winestone LE, Gergis U, Nathan S, Olsson RF, Verdonck LF, Sharma A, Ringdén O, Friend BD, Cerny J, Choe H, Chhabra S, Nishihori T, Seo S, George B, Baxter-Lowe LA, Hildebrandt GC, de Lima M, Litzow M, Kebriaei P, Hourigan CS, Abid MB, Weisdorf DJ, Saber W
Blood Adv 2022 Jan 11;6(1):339-357. doi: 10.1182/bloodadvances.2021004916. PMID: 34547770Free PMC Article
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.
Watkins B, Qayed M, McCracken C, Bratrude B, Betz K, Suessmuth Y, Yu A, Sinclair S, Furlan S, Bosinger S, Tkachev V, Rhodes J, Tumlin AG, Narayan A, Cribbin K, Gillespie S, Gooley TA, Pasquini MC, Hebert K, Kapoor U, Rogatko A, Tighiouart M, Kim S, Bresee C, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Waller EK, Levine JE, Ferrara JL, Blazar BR, Langston A, Horan JT, Kean LS
J Clin Oncol 2021 Jun 10;39(17):1865-1877. Epub 2021 Jan 15 doi: 10.1200/JCO.20.01086. PMID: 33449816Free PMC Article
Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia.
Bejanyan N, Kim S, Hebert KM, Kekre N, Abdel-Azim H, Ahmed I, Aljurf M, Badawy SM, Beitinjaneh A, Boelens JJ, Diaz MA, Dvorak CC, Gadalla S, Gajewski J, Gale RP, Ganguly S, Gennery AR, George B, Gergis U, Gómez-Almaguer D, Vicent MG, Hashem H, Kamble RT, Kasow KA, Lazarus HM, Mathews V, Orchard PJ, Pulsipher M, Ringden O, Schultz K, Teira P, Woolfrey AE, Saldaña BD, Savani B, Winiarski J, Yared J, Weisdorf DJ, Antin JH, Eapen M
Blood Adv 2019 Oct 22;3(20):3123-3131. doi: 10.1182/bloodadvances.2019000722. PMID: 31648332Free PMC Article
Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial.
Gæde P, Oellgaard J, Carstensen B, Rossing P, Lund-Andersen H, Parving HH, Pedersen O
Diabetologia 2016 Nov;59(11):2298-2307. Epub 2016 Aug 16 doi: 10.1007/s00125-016-4065-6. PMID: 27531506Free PMC Article

Prognosis

Impact of MRD on clinical outcomes of unrelated hematopoietic stem cell transplantation in patients with Ph(+) ALL: A retrospective nationwide study.
Hirabayashi S, Kondo T, Nishiwaki S, Mizuta S, Doki N, Fukuda T, Uchida N, Ozawa Y, Kanda Y, Imanaka R, Takahashi S, Ishikawa J, Yano S, Nakamae H, Eto T, Kimura T, Tanaka J, Ichinohe T, Atsuta Y, Kako S
Am J Hematol 2023 Oct;98(10):1606-1618. Epub 2023 Jul 26 doi: 10.1002/ajh.27041. PMID: 37493218
Three-Year Outcomes in Recipients of Mismatched Unrelated Bone Marrow Donor Transplants Using Post-Transplantation Cyclophosphamide: Follow-Up from a National Marrow Donor Program-Sponsored Prospective Clinical Trial.
Shaw BE, Jimenez-Jimenez AM, Burns LJ, Logan BR, Khimani F, Shaffer BC, Shah NN, Mussetter A, Tang XY, McCarty JM, Alavi A, Farhadfar N, Jamieson K, Hardy NM, Choe H, Ambinder RF, Anasetti C, Perales MA, Spellman SR, Howard A, Komanduri KV, Luznik L, Norkin M, Pidala JA, Ratanatharathorn V, Confer DL, Devine SM, Horowitz MM, Bolaños-Meade J
Transplant Cell Ther 2023 Mar;29(3):208.e1-208.e6. Epub 2022 Dec 27 doi: 10.1016/j.jtct.2022.12.017. PMID: 36584941Free PMC Article
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.
Watkins B, Qayed M, McCracken C, Bratrude B, Betz K, Suessmuth Y, Yu A, Sinclair S, Furlan S, Bosinger S, Tkachev V, Rhodes J, Tumlin AG, Narayan A, Cribbin K, Gillespie S, Gooley TA, Pasquini MC, Hebert K, Kapoor U, Rogatko A, Tighiouart M, Kim S, Bresee C, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Waller EK, Levine JE, Ferrara JL, Blazar BR, Langston A, Horan JT, Kean LS
J Clin Oncol 2021 Jun 10;39(17):1865-1877. Epub 2021 Jan 15 doi: 10.1200/JCO.20.01086. PMID: 33449816Free PMC Article
Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia.
Bejanyan N, Kim S, Hebert KM, Kekre N, Abdel-Azim H, Ahmed I, Aljurf M, Badawy SM, Beitinjaneh A, Boelens JJ, Diaz MA, Dvorak CC, Gadalla S, Gajewski J, Gale RP, Ganguly S, Gennery AR, George B, Gergis U, Gómez-Almaguer D, Vicent MG, Hashem H, Kamble RT, Kasow KA, Lazarus HM, Mathews V, Orchard PJ, Pulsipher M, Ringden O, Schultz K, Teira P, Woolfrey AE, Saldaña BD, Savani B, Winiarski J, Yared J, Weisdorf DJ, Antin JH, Eapen M
Blood Adv 2019 Oct 22;3(20):3123-3131. doi: 10.1182/bloodadvances.2019000722. PMID: 31648332Free PMC Article
Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial.
Gæde P, Oellgaard J, Carstensen B, Rossing P, Lund-Andersen H, Parving HH, Pedersen O
Diabetologia 2016 Nov;59(11):2298-2307. Epub 2016 Aug 16 doi: 10.1007/s00125-016-4065-6. PMID: 27531506Free PMC Article

Clinical prediction guides

Practice patterns and clinical outcomes of platelet alloimmunization in a comprehensive cancer center.
Goswamy RV, Wilson NR, Tannenbaum DJ, Aung FM, Hernandez CMR
Transfus Apher Sci 2021 Jun;60(3):103096. Epub 2021 Feb 13 doi: 10.1016/j.transci.2021.103096. PMID: 33612449
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.
Watkins B, Qayed M, McCracken C, Bratrude B, Betz K, Suessmuth Y, Yu A, Sinclair S, Furlan S, Bosinger S, Tkachev V, Rhodes J, Tumlin AG, Narayan A, Cribbin K, Gillespie S, Gooley TA, Pasquini MC, Hebert K, Kapoor U, Rogatko A, Tighiouart M, Kim S, Bresee C, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Waller EK, Levine JE, Ferrara JL, Blazar BR, Langston A, Horan JT, Kean LS
J Clin Oncol 2021 Jun 10;39(17):1865-1877. Epub 2021 Jan 15 doi: 10.1200/JCO.20.01086. PMID: 33449816Free PMC Article
Racial disparities in access to HLA-matched unrelated donor transplants: a prospective 1312-patient analysis.
Barker JN, Boughan K, Dahi PB, Devlin SM, Maloy MA, Naputo K, Mazis CM, Davis E, Nhaissi M, Wells D, Cooper C, Ponce DM, Kernan N, Scaradavou A, Giralt SA, Papadopoulos EB, Politikos I
Blood Adv 2019 Apr 9;3(7):939-944. doi: 10.1182/bloodadvances.2018028662. PMID: 30917950Free PMC Article
Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial.
Gæde P, Oellgaard J, Carstensen B, Rossing P, Lund-Andersen H, Parving HH, Pedersen O
Diabetologia 2016 Nov;59(11):2298-2307. Epub 2016 Aug 16 doi: 10.1007/s00125-016-4065-6. PMID: 27531506Free PMC Article
HLA mismatching as a strategy to reduce relapse after alternative donor transplantation.
Fleischhauer K, Beelen DW
Semin Hematol 2016 Apr;53(2):57-64. Epub 2016 Jan 15 doi: 10.1053/j.seminhematol.2016.01.010. PMID: 27000727

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