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Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score 4

MedGen UID:
1832313
•Concept ID:
C5784535
•
Finding
Synonym: CAD-RADS CCTA Score 4

Definition

A Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score that indicates that severe stenosis (70-99%) or left main stenosis greater than or equal to 50% or 3-vessel obstructive (greater than or equal to 70%) disease is present. [from NCI]

Professional guidelines

PubMed

Association between Coronary Artery Disease Reporting and Data System-recommended Post-Coronary CT Angiography Management and Clinical Outcomes in Patients with Stable Chest Pain from a Chinese Registry.
Zhou J, Li C, Zhang H, Liu C, Yang J, Zhao J, Hou Y, Tan Y, Wang H, Li Y, Xie C, Wang M, Wang C, Zhang E, Wang S, Zhao P, Shan D, Liang S, Gao Y, Huo Y, Cong H, Guo Z, Chen Y
Radiology 2023 Jun;307(5):e222965. doi: 10.1148/radiol.222965. PMID: 37310243
Clinical utility of coronary computed tomography angiography in patients diagnosed with high-grade stenosis of the coronary arteries.
Kim C, Hong SJ, Shin S, Ahn CM, Kim JS, Kim BK, Ko YG, Choi BW, Choi D, Jang Y, Hong MK
Coron Artery Dis 2019 Nov;30(7):511-519. doi: 10.1097/MCA.0000000000000750. PMID: 30985482

Recent clinical studies

Etiology

Phenotyping coronary plaque by computed tomography in premature coronary artery disease.
Rahoual G, Zeitouni M, Charpentier E, Ritvo PG, Rouanet S, Procopi N, Boukhelifa S, Charleux P, Guedeney P, Kerneis M, Barthélémy O, Silvain J, Montalescot G, Redheuil A, Collet JP
Eur Heart J Cardiovasc Imaging 2024 Jan 29;25(2):257-266. doi: 10.1093/ehjci/jead212. PMID: 37597177
AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD.
Nurmohamed NS, Bom MJ, Jukema RA, de Groot RJ, Driessen RS, van Diemen PA, de Winter RW, Gaillard EL, Sprengers RW, Stroes ESG, Min JK, Earls JP, Cardoso R, Blankstein R, Danad I, Choi AD, Knaapen P
JACC Cardiovasc Imaging 2024 Mar;17(3):269-280. Epub 2023 Jul 19 doi: 10.1016/j.jcmg.2023.05.020. PMID: 37480907
Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability.
Kinoshita D, Suzuki K, Yuki H, Niida T, Fujimoto D, Minami Y, Dey D, Lee H, McNulty I, Ako J, Ghoshhajra B, Ferencik M, Kakuta T, Jang IK
J Cardiovasc Comput Tomogr 2023 Nov-Dec;17(6):445-452. Epub 2023 Oct 8 doi: 10.1016/j.jcct.2023.09.008. PMID: 37813721
Association between Coronary Artery Disease Reporting and Data System-recommended Post-Coronary CT Angiography Management and Clinical Outcomes in Patients with Stable Chest Pain from a Chinese Registry.
Zhou J, Li C, Zhang H, Liu C, Yang J, Zhao J, Hou Y, Tan Y, Wang H, Li Y, Xie C, Wang M, Wang C, Zhang E, Wang S, Zhao P, Shan D, Liang S, Gao Y, Huo Y, Cong H, Guo Z, Chen Y
Radiology 2023 Jun;307(5):e222965. doi: 10.1148/radiol.222965. PMID: 37310243
Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study.
Lin A, Manral N, McElhinney P, Killekar A, Matsumoto H, Kwiecinski J, Pieszko K, Razipour A, Grodecki K, Park C, Otaki Y, Doris M, Kwan AC, Han D, Kuronuma K, Flores Tomasino G, Tzolos E, Shanbhag A, Goeller M, Marwan M, Gransar H, Tamarappoo BK, Cadet S, Achenbach S, Nicholls SJ, Wong DT, Berman DS, Dweck M, Newby DE, Williams MC, Slomka PJ, Dey D
Lancet Digit Health 2022 Apr;4(4):e256-e265. doi: 10.1016/S2589-7500(22)00022-X. PMID: 35337643Free PMC Article

Diagnosis

Phenotyping coronary plaque by computed tomography in premature coronary artery disease.
Rahoual G, Zeitouni M, Charpentier E, Ritvo PG, Rouanet S, Procopi N, Boukhelifa S, Charleux P, Guedeney P, Kerneis M, Barthélémy O, Silvain J, Montalescot G, Redheuil A, Collet JP
Eur Heart J Cardiovasc Imaging 2024 Jan 29;25(2):257-266. doi: 10.1093/ehjci/jead212. PMID: 37597177
AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD.
Nurmohamed NS, Bom MJ, Jukema RA, de Groot RJ, Driessen RS, van Diemen PA, de Winter RW, Gaillard EL, Sprengers RW, Stroes ESG, Min JK, Earls JP, Cardoso R, Blankstein R, Danad I, Choi AD, Knaapen P
JACC Cardiovasc Imaging 2024 Mar;17(3):269-280. Epub 2023 Jul 19 doi: 10.1016/j.jcmg.2023.05.020. PMID: 37480907
Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability.
Kinoshita D, Suzuki K, Yuki H, Niida T, Fujimoto D, Minami Y, Dey D, Lee H, McNulty I, Ako J, Ghoshhajra B, Ferencik M, Kakuta T, Jang IK
J Cardiovasc Comput Tomogr 2023 Nov-Dec;17(6):445-452. Epub 2023 Oct 8 doi: 10.1016/j.jcct.2023.09.008. PMID: 37813721
Coronary artery disease imaging reporting and data system (CAD-RADS): what radiologists need to know?
Razek AAKA, Fahmy D
Emerg Radiol 2021 Dec;28(6):1185-1203. Epub 2021 Aug 13 doi: 10.1007/s10140-021-01973-8. PMID: 34387783
Latent Tuberculosis Infection and Subclinical Coronary Atherosclerosis in Peru and Uganda.
Huaman MA, De Cecco CN, Bittencourt MS, Ticona E, Kityo C, Ballena I, Nalukwago S, Nazzinda R, Ticona C, Azañero R, Zhang B, Farquhar C, Hawn TR, Sterling TR, Fichtenbaum CJ, Longenecker CT
Clin Infect Dis 2021 Nov 2;73(9):e3384-e3390. doi: 10.1093/cid/ciaa1934. PMID: 33388766Free PMC Article

Therapy

Combination of computed tomography angiography with coronary artery calcium score for improved diagnosis of coronary artery disease: a collaborative meta-analysis of stable chest pain patients referred for invasive coronary angiography.
Mohamed M, Bosserdt M, Wieske V, Dubourg B, Alkadhi H, Garcia MJ, Leschka S, Zimmermann E, Shabestari AA, Nørgaard BL, Meijs MFL, Øvrehus KA, Diederichsen ACP, Knuuti J, Halvorsen BA, Mendoza-Rodriguez V, Wan YL, Bettencourt N, Martuscelli E, Buechel RR, Mickley H, Sun K, Muraglia S, Kaufmann PA, Herzog BA, Tardif JC, Schütz GM, Laule M, Newby DE, Achenbach S, Budoff M, Haase R, Biavati F, Mézquita AV, Schlattmann P, Dewey M; COME-CCT
Eur Radiol 2024 Apr;34(4):2426-2436. Epub 2023 Oct 13 doi: 10.1007/s00330-023-10223-z. PMID: 37831139Free PMC Article
Atherosclerosis on CT coronary angiography and the risk of long-term cardiovascular events after liver transplantation.
Sampaio Rodrigues T, Koshy AN, Gow PJ, Weinberg L, Cailes B, Testro A, Smith G, Lim HS, Teh AW, Lim RP, Farouque O
Liver Transpl 2024 Feb 1;30(2):182-191. Epub 2023 Jul 12 doi: 10.1097/LVT.0000000000000215. PMID: 37432891
Drugless and radiographer led: the start of a new era for CT coronary angiography.
Morgan-Hughes G, McNally R, Gibbs CG, Iacovides S, Kirat-Rai P, Thiriphoo N, Powell A, Stuckey C, Thorpe R, Mayo L, Roobottom C
Open Heart 2023 Jun;10(1) doi: 10.1136/openhrt-2023-002263. PMID: 37349131Free PMC Article
Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study.
Lin A, Manral N, McElhinney P, Killekar A, Matsumoto H, Kwiecinski J, Pieszko K, Razipour A, Grodecki K, Park C, Otaki Y, Doris M, Kwan AC, Han D, Kuronuma K, Flores Tomasino G, Tzolos E, Shanbhag A, Goeller M, Marwan M, Gransar H, Tamarappoo BK, Cadet S, Achenbach S, Nicholls SJ, Wong DT, Berman DS, Dweck M, Newby DE, Williams MC, Slomka PJ, Dey D
Lancet Digit Health 2022 Apr;4(4):e256-e265. doi: 10.1016/S2589-7500(22)00022-X. PMID: 35337643Free PMC Article
Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.
Rieckmann N, Neumann K, Feger S, Ibes P, Napp A, Preuß D, Dreger H, Feuchtner G, Plank F, Suchánek V, Veselka J, Engstrøm T, Kofoed KF, Schröder S, Zelesny T, Gutberlet M, Woinke M, Maurovich-Horvat P, Merkely B, Donnelly P, Ball P, Dodd JD, Hensey M, Loi B, Saba L, Francone M, Mancone M, Berzina M, Erglis A, Vaitiekiene A, Zajanckauskiene L, Harań T, Suckiel MI, Faria R, Gama-Ribeiro V, Benedek I, Rodean I, Adjić F, Čemerlić Adjić N, Rodriguez-Palomares J, Garcia Del Blanco B, Brooksbank K, Collison D, Davis G, Thwaite E, Knuuti J, Saraste A, Kępka C, Kruk M, Benedek T, Ratiu M, Neskovic AN, Vidakovic R, Diez I, Lecumberri I, Fisher M, Ruzsics B, Hollingworth W, Gutiérrez-Ibarluzea I, Dewey M, Müller-Nordhorn J
Health Qual Life Outcomes 2020 May 14;18(1):140. doi: 10.1186/s12955-020-01312-4. PMID: 32410687Free PMC Article

Prognosis

Phenotyping coronary plaque by computed tomography in premature coronary artery disease.
Rahoual G, Zeitouni M, Charpentier E, Ritvo PG, Rouanet S, Procopi N, Boukhelifa S, Charleux P, Guedeney P, Kerneis M, Barthélémy O, Silvain J, Montalescot G, Redheuil A, Collet JP
Eur Heart J Cardiovasc Imaging 2024 Jan 29;25(2):257-266. doi: 10.1093/ehjci/jead212. PMID: 37597177
AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD.
Nurmohamed NS, Bom MJ, Jukema RA, de Groot RJ, Driessen RS, van Diemen PA, de Winter RW, Gaillard EL, Sprengers RW, Stroes ESG, Min JK, Earls JP, Cardoso R, Blankstein R, Danad I, Choi AD, Knaapen P
JACC Cardiovasc Imaging 2024 Mar;17(3):269-280. Epub 2023 Jul 19 doi: 10.1016/j.jcmg.2023.05.020. PMID: 37480907
Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability.
Kinoshita D, Suzuki K, Yuki H, Niida T, Fujimoto D, Minami Y, Dey D, Lee H, McNulty I, Ako J, Ghoshhajra B, Ferencik M, Kakuta T, Jang IK
J Cardiovasc Comput Tomogr 2023 Nov-Dec;17(6):445-452. Epub 2023 Oct 8 doi: 10.1016/j.jcct.2023.09.008. PMID: 37813721
Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study.
Lin A, Manral N, McElhinney P, Killekar A, Matsumoto H, Kwiecinski J, Pieszko K, Razipour A, Grodecki K, Park C, Otaki Y, Doris M, Kwan AC, Han D, Kuronuma K, Flores Tomasino G, Tzolos E, Shanbhag A, Goeller M, Marwan M, Gransar H, Tamarappoo BK, Cadet S, Achenbach S, Nicholls SJ, Wong DT, Berman DS, Dweck M, Newby DE, Williams MC, Slomka PJ, Dey D
Lancet Digit Health 2022 Apr;4(4):e256-e265. doi: 10.1016/S2589-7500(22)00022-X. PMID: 35337643Free PMC Article
Coronary artery disease imaging reporting and data system (CAD-RADS): what radiologists need to know?
Razek AAKA, Fahmy D
Emerg Radiol 2021 Dec;28(6):1185-1203. Epub 2021 Aug 13 doi: 10.1007/s10140-021-01973-8. PMID: 34387783

Clinical prediction guides

AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD.
Nurmohamed NS, Bom MJ, Jukema RA, de Groot RJ, Driessen RS, van Diemen PA, de Winter RW, Gaillard EL, Sprengers RW, Stroes ESG, Min JK, Earls JP, Cardoso R, Blankstein R, Danad I, Choi AD, Knaapen P
JACC Cardiovasc Imaging 2024 Mar;17(3):269-280. Epub 2023 Jul 19 doi: 10.1016/j.jcmg.2023.05.020. PMID: 37480907
Coronary artery disease reporting and data system (CAD-RADS), vascular inflammation and plaque vulnerability.
Kinoshita D, Suzuki K, Yuki H, Niida T, Fujimoto D, Minami Y, Dey D, Lee H, McNulty I, Ako J, Ghoshhajra B, Ferencik M, Kakuta T, Jang IK
J Cardiovasc Comput Tomogr 2023 Nov-Dec;17(6):445-452. Epub 2023 Oct 8 doi: 10.1016/j.jcct.2023.09.008. PMID: 37813721
Association between Coronary Artery Disease Reporting and Data System-recommended Post-Coronary CT Angiography Management and Clinical Outcomes in Patients with Stable Chest Pain from a Chinese Registry.
Zhou J, Li C, Zhang H, Liu C, Yang J, Zhao J, Hou Y, Tan Y, Wang H, Li Y, Xie C, Wang M, Wang C, Zhang E, Wang S, Zhao P, Shan D, Liang S, Gao Y, Huo Y, Cong H, Guo Z, Chen Y
Radiology 2023 Jun;307(5):e222965. doi: 10.1148/radiol.222965. PMID: 37310243
Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study.
Lin A, Manral N, McElhinney P, Killekar A, Matsumoto H, Kwiecinski J, Pieszko K, Razipour A, Grodecki K, Park C, Otaki Y, Doris M, Kwan AC, Han D, Kuronuma K, Flores Tomasino G, Tzolos E, Shanbhag A, Goeller M, Marwan M, Gransar H, Tamarappoo BK, Cadet S, Achenbach S, Nicholls SJ, Wong DT, Berman DS, Dweck M, Newby DE, Williams MC, Slomka PJ, Dey D
Lancet Digit Health 2022 Apr;4(4):e256-e265. doi: 10.1016/S2589-7500(22)00022-X. PMID: 35337643Free PMC Article
Coronary artery disease imaging reporting and data system (CAD-RADS): what radiologists need to know?
Razek AAKA, Fahmy D
Emerg Radiol 2021 Dec;28(6):1185-1203. Epub 2021 Aug 13 doi: 10.1007/s10140-021-01973-8. PMID: 34387783

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