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Steroid metabolism disease

MedGen UID:
541265
•Concept ID:
C0268283
•
Disease or Syndrome
Synonyms: disorder of steroid metabolic process; Disorder of steroid metabolism; disorder of steroid metabolism; steroid metabolic process disease; steroid metabolism disease
SNOMED CT: Disorder of steroid metabolism (28710006)
 
Monarch Initiative: MONDO:0045012

Definition

A disease that has its basis in the disruption of steroid metabolic process. [from MONDO]

Professional guidelines

PubMed

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.
Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, Torpy DJ
J Clin Endocrinol Metab 2016 Feb;101(2):364-89. Epub 2016 Jan 13 doi: 10.1210/jc.2015-1710. PMID: 26760044Free PMC Article

Recent clinical studies

Etiology

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria.
Li C, Stražar M, Mohamed AMT, Pacheco JA, Walker RL, Lebar T, Zhao S, Lockart J, Dame A, Thurimella K, Jeanfavre S, Brown EM, Ang QY, Berdy B, Sergio D, Invernizzi R, Tinoco A, Pishchany G, Vasan RS, Balskus E, Huttenhower C, Vlamakis H, Clish C, Shaw SY, Plichta DR, Xavier RJ
Cell 2024 Apr 11;187(8):1834-1852.e19. Epub 2024 Apr 2 doi: 10.1016/j.cell.2024.03.014. PMID: 38569543Free PMC Article
Primary aldosteronism - a multidimensional syndrome.
Turcu AF, Yang J, Vaidya A
Nat Rev Endocrinol 2022 Nov;18(11):665-682. Epub 2022 Aug 31 doi: 10.1038/s41574-022-00730-2. PMID: 36045149
HDL Cholesterol and Non-Cardiovascular Disease: A Narrative Review.
Kjeldsen EW, Nordestgaard LT, Frikke-Schmidt R
Int J Mol Sci 2021 Apr 27;22(9) doi: 10.3390/ijms22094547. PMID: 33925284Free PMC Article
Bile acid metabolism and circadian rhythms.
Yang Y, Zhang J
Am J Physiol Gastrointest Liver Physiol 2020 Nov 1;319(5):G549-G563. Epub 2020 Sep 9 doi: 10.1152/ajpgi.00152.2020. PMID: 32902316
Effects of androgenic-anabolic steroids in athletes.
Hartgens F, Kuipers H
Sports Med 2004;34(8):513-54. doi: 10.2165/00007256-200434080-00003. PMID: 15248788

Diagnosis

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria.
Li C, Stražar M, Mohamed AMT, Pacheco JA, Walker RL, Lebar T, Zhao S, Lockart J, Dame A, Thurimella K, Jeanfavre S, Brown EM, Ang QY, Berdy B, Sergio D, Invernizzi R, Tinoco A, Pishchany G, Vasan RS, Balskus E, Huttenhower C, Vlamakis H, Clish C, Shaw SY, Plichta DR, Xavier RJ
Cell 2024 Apr 11;187(8):1834-1852.e19. Epub 2024 Apr 2 doi: 10.1016/j.cell.2024.03.014. PMID: 38569543Free PMC Article
Primary aldosteronism - a multidimensional syndrome.
Turcu AF, Yang J, Vaidya A
Nat Rev Endocrinol 2022 Nov;18(11):665-682. Epub 2022 Aug 31 doi: 10.1038/s41574-022-00730-2. PMID: 36045149
Primary Hyperaldosteronism: Approach to Diagnosis and Management.
El-Asmar N, Rajpal A, Arafah BM
Med Clin North Am 2021 Nov;105(6):1065-1080. Epub 2021 Sep 9 doi: 10.1016/j.mcna.2021.06.007. PMID: 34688415
Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment.
Hwang JL, Weiss RE
Diabetes Metab Res Rev 2014 Feb;30(2):96-102. doi: 10.1002/dmrr.2486. PMID: 24123849Free PMC Article
Testosterone: a metabolic hormone in health and disease.
Kelly DM, Jones TH
J Endocrinol 2013 Jun;217(3):R25-45. Epub 2013 Apr 29 doi: 10.1530/JOE-12-0455. PMID: 23378050

Therapy

Adenosine Triphosphate Citrate Lyase and Fatty Acid Synthesis Inhibition: A Narrative Review.
Duarte Lau F, Giugliano RP
JAMA Cardiol 2023 Sep 1;8(9):879-887. doi: 10.1001/jamacardio.2023.2402. PMID: 37585218
HDL Cholesterol and Non-Cardiovascular Disease: A Narrative Review.
Kjeldsen EW, Nordestgaard LT, Frikke-Schmidt R
Int J Mol Sci 2021 Apr 27;22(9) doi: 10.3390/ijms22094547. PMID: 33925284Free PMC Article
Exploring vitamin D metabolism and function in cancer.
Jeon SM, Shin EA
Exp Mol Med 2018 Apr 16;50(4):1-14. doi: 10.1038/s12276-018-0038-9. PMID: 29657326Free PMC Article
Causal associations between risk factors and common diseases inferred from GWAS summary data.
Zhu Z, Zheng Z, Zhang F, Wu Y, Trzaskowski M, Maier R, Robinson MR, McGrath JJ, Visscher PM, Wray NR, Yang J
Nat Commun 2018 Jan 15;9(1):224. doi: 10.1038/s41467-017-02317-2. PMID: 29335400Free PMC Article
Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment.
Hwang JL, Weiss RE
Diabetes Metab Res Rev 2014 Feb;30(2):96-102. doi: 10.1002/dmrr.2486. PMID: 24123849Free PMC Article

Prognosis

Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-analyses.
Yeap BB, Marriott RJ, Dwivedi G, Adams RJ, Antonio L, Ballantyne CM, Bauer DC, Bhasin S, Biggs ML, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Handelsman DJ, Hankey GJ, Hannemann A, Haring R, Hsu B, Martin SA, Matsumoto AM, Mellström D, Ohlsson C, O'Neill TW, Orwoll ES, Quartagno M, Shores MM, Steveling A, Tivesten Å, Travison TG, Vanderschueren D, Wittert GA, Wu FCW, Murray K
Ann Intern Med 2024 Jun;177(6):768-781. Epub 2024 May 14 doi: 10.7326/M23-2781. PMID: 38739921
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria.
Li C, Stražar M, Mohamed AMT, Pacheco JA, Walker RL, Lebar T, Zhao S, Lockart J, Dame A, Thurimella K, Jeanfavre S, Brown EM, Ang QY, Berdy B, Sergio D, Invernizzi R, Tinoco A, Pishchany G, Vasan RS, Balskus E, Huttenhower C, Vlamakis H, Clish C, Shaw SY, Plichta DR, Xavier RJ
Cell 2024 Apr 11;187(8):1834-1852.e19. Epub 2024 Apr 2 doi: 10.1016/j.cell.2024.03.014. PMID: 38569543Free PMC Article
Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease.
Ganmaa D, Uyanga B, Zhou X, Gantsetseg G, Delgerekh B, Enkhmaa D, Khulan D, Ariunzaya S, Sumiya E, Bolortuya B, Yanjmaa J, Enkhtsetseg T, Munkhzaya A, Tunsag M, Khudyakov P, Seddon JA, Marais BJ, Batbayar O, Erdenetuya G, Amarsaikhan B, Spiegelman D, Tsolmon J, Martineau AR
N Engl J Med 2020 Jul 23;383(4):359-368. doi: 10.1056/NEJMoa1915176. PMID: 32706534Free PMC Article
Triglyceride-Rich Lipoprotein Cholesterol, Small Dense LDL Cholesterol, and Incident Cardiovascular Disease.
Duran EK, Aday AW, Cook NR, Buring JE, Ridker PM, Pradhan AD
J Am Coll Cardiol 2020 May 5;75(17):2122-2135. doi: 10.1016/j.jacc.2020.02.059. PMID: 32354380Free PMC Article
Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis.
Ference BA, Yoo W, Alesh I, Mahajan N, Mirowska KK, Mewada A, Kahn J, Afonso L, Williams KA Sr, Flack JM
J Am Coll Cardiol 2012 Dec 25;60(25):2631-9. Epub 2012 Oct 17 doi: 10.1016/j.jacc.2012.09.017. PMID: 23083789

Clinical prediction guides

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria.
Li C, Stražar M, Mohamed AMT, Pacheco JA, Walker RL, Lebar T, Zhao S, Lockart J, Dame A, Thurimella K, Jeanfavre S, Brown EM, Ang QY, Berdy B, Sergio D, Invernizzi R, Tinoco A, Pishchany G, Vasan RS, Balskus E, Huttenhower C, Vlamakis H, Clish C, Shaw SY, Plichta DR, Xavier RJ
Cell 2024 Apr 11;187(8):1834-1852.e19. Epub 2024 Apr 2 doi: 10.1016/j.cell.2024.03.014. PMID: 38569543Free PMC Article
Dehydroepiandrosterone (DHEA): Pharmacological Effects and Potential Therapeutic Application.
Nenezic N, Kostic S, Strac DS, Grunauer M, Nenezic D, Radosavljevic M, Jancic J, Samardzic J
Mini Rev Med Chem 2023;23(8):941-952. doi: 10.2174/1389557522666220919125817. PMID: 36121077
HDL Cholesterol and Non-Cardiovascular Disease: A Narrative Review.
Kjeldsen EW, Nordestgaard LT, Frikke-Schmidt R
Int J Mol Sci 2021 Apr 27;22(9) doi: 10.3390/ijms22094547. PMID: 33925284Free PMC Article
Testosterone: a metabolic hormone in health and disease.
Kelly DM, Jones TH
J Endocrinol 2013 Jun;217(3):R25-45. Epub 2013 Apr 29 doi: 10.1530/JOE-12-0455. PMID: 23378050
Effects of androgenic-anabolic steroids in athletes.
Hartgens F, Kuipers H
Sports Med 2004;34(8):513-54. doi: 10.2165/00007256-200434080-00003. PMID: 15248788

Recent systematic reviews

Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis.
Formisano E, Proietti E, Borgarelli C, Pisciotta L
Nutrients 2023 Jul 30;15(15) doi: 10.3390/nu15153387. PMID: 37571324Free PMC Article
IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome.
Trautmann A, Boyer O, Hodson E, Bagga A, Gipson DS, Samuel S, Wetzels J, Alhasan K, Banerjee S, Bhimma R, Bonilla-Felix M, Cano F, Christian M, Hahn D, Kang HG, Nakanishi K, Safouh H, Trachtman H, Xu H, Cook W, Vivarelli M, Haffner D; International Pediatric Nephrology Association
Pediatr Nephrol 2023 Mar;38(3):877-919. Epub 2022 Oct 21 doi: 10.1007/s00467-022-05739-3. PMID: 36269406Free PMC Article
Vitamin D and Ocular Diseases: A Systematic Review.
Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, Chu WK, Chen LJ, Tham CC, Yam JC, Pang CP
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084226. PMID: 35457041Free PMC Article
The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials.
Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A
BMC Complement Med Ther 2021 Jun 29;21(1):179. doi: 10.1186/s12906-021-03351-w. PMID: 34187442Free PMC Article
Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis.
Adam EK, Quinn ME, Tavernier R, McQuillan MT, Dahlke KA, Gilbert KE
Psychoneuroendocrinology 2017 Sep;83:25-41. Epub 2017 May 24 doi: 10.1016/j.psyneuen.2017.05.018. PMID: 28578301Free PMC Article

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