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  • The following terms were not found in MedGen: Bromo, trifluoromethyl, pyridin, 5-Bromo-4-trifluoromethyl-pyridin-2-ol.

pentostatin

MedGen UID:
10633
•Concept ID:
C0030896
•
Antibiotic; Nucleic Acid, Nucleoside, or Nucleotide
Synonyms: 2' Deoxycoformycin; 2'-Deoxycoformycin; Deoxycoformycin; Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-; Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-; Pentostatin
SNOMED CT: Pentostatin (387154004); Deoxycoformycin (387154004); Pentostatin-containing product (28149003)
Drug response:
Pentostatin response
MedGen UID:
982456
•Concept ID:
CN298613
•
Sign or Symptom
Pentostatin response

Definition

A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2''-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04) [from NCI]

Professional guidelines

PubMed

Long-term results for pentostatin and cladribine treatment of hairy cell leukemia.
Dearden CE, Else M, Catovsky D
Leuk Lymphoma 2011 Jun;52 Suppl 2:21-4. doi: 10.3109/10428194.2011.565093. PMID: 21599603
Pentostatin treatment combinations in chronic lymphocytic leukemia.
Lamanna N, Kay NE
Clin Adv Hematol Oncol 2009 Jun;7(6):386-92. PMID: 19606074
Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention.
Pai VB, Nahata MC
Drug Saf 2000 Apr;22(4):263-302. doi: 10.2165/00002018-200022040-00002. PMID: 10789823

Recent clinical studies

Etiology

Hairy Cell Leukemia: Where Are We in 2023?
Mendez-Hernandez A, Moturi K, Hanson V, Andritsos LA
Curr Oncol Rep 2023 Aug;25(8):833-840. Epub 2023 Apr 25 doi: 10.1007/s11912-023-01419-z. PMID: 37097545Free PMC Article
Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.
Grever MR, Abdel-Wahab O, Andritsos LA, Banerji V, Barrientos J, Blachly JS, Call TG, Catovsky D, Dearden C, Demeter J, Else M, Forconi F, Gozzetti A, Ho AD, Johnston JB, Jones J, Juliusson G, Kraut E, Kreitman RJ, Larratt L, Lauria F, Lozanski G, Montserrat E, Parikh SA, Park JH, Polliack A, Quest GR, Rai KR, Ravandi F, Robak T, Saven A, Seymour JF, Tadmor T, Tallman MS, Tam C, Tiacci E, Troussard X, Zent CS, Zenz T, Zinzani PL, Falini B
Blood 2017 Feb 2;129(5):553-560. Epub 2016 Nov 30 doi: 10.1182/blood-2016-01-689422. PMID: 27903528Free PMC Article
Treatment of T-Cell lymphoma.
Hotta T
Hematology 2005;10 Suppl 1:193-6. doi: 10.1080/10245330512331390393. PMID: 16188671
Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention.
Pai VB, Nahata MC
Drug Saf 2000 Apr;22(4):263-302. doi: 10.2165/00002018-200022040-00002. PMID: 10789823
Hypersensitivity reactions.
Weiss RB
Semin Oncol 1992 Oct;19(5):458-77. PMID: 1384149

Diagnosis

Hairy Cell Leukemia: Where Are We in 2023?
Mendez-Hernandez A, Moturi K, Hanson V, Andritsos LA
Curr Oncol Rep 2023 Aug;25(8):833-840. Epub 2023 Apr 25 doi: 10.1007/s11912-023-01419-z. PMID: 37097545Free PMC Article
Hairy Cell Leukaemia.
Cross M, Dearden C
Curr Oncol Rep 2020 Apr 16;22(5):42. doi: 10.1007/s11912-020-00911-0. PMID: 32297104
Update on hairy cell leukemia.
Kreitman RJ, Arons E
Clin Adv Hematol Oncol 2018 Mar;16(3):205-215. PMID: 29742076Free PMC Article
Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.
Grever MR, Abdel-Wahab O, Andritsos LA, Banerji V, Barrientos J, Blachly JS, Call TG, Catovsky D, Dearden C, Demeter J, Else M, Forconi F, Gozzetti A, Ho AD, Johnston JB, Jones J, Juliusson G, Kraut E, Kreitman RJ, Larratt L, Lauria F, Lozanski G, Montserrat E, Parikh SA, Park JH, Polliack A, Quest GR, Rai KR, Ravandi F, Robak T, Saven A, Seymour JF, Tadmor T, Tallman MS, Tam C, Tiacci E, Troussard X, Zent CS, Zenz T, Zinzani PL, Falini B
Blood 2017 Feb 2;129(5):553-560. Epub 2016 Nov 30 doi: 10.1182/blood-2016-01-689422. PMID: 27903528Free PMC Article
T-cell prolymphocytic leukemia.
Dearden CE
Clin Lymphoma Myeloma 2009;9 Suppl 3:S239-43. doi: 10.3816/CLM.2009.s.018. PMID: 19778847

Therapy

Development of Recombinant Immunotoxins for Hairy Cell Leukemia.
Kreitman RJ, Pastan I
Biomolecules 2020 Aug 3;10(8) doi: 10.3390/biom10081140. PMID: 32756468Free PMC Article
Hairy cell leukemia: present and future directions.
Kreitman RJ
Leuk Lymphoma 2019 Dec;60(12):2869-2879. Epub 2019 May 9 doi: 10.1080/10428194.2019.1608536. PMID: 31068044Free PMC Article
T-cell prolymphocytic leukemia.
Dearden CE
Clin Lymphoma Myeloma 2009;9 Suppl 3:S239-43. doi: 10.3816/CLM.2009.s.018. PMID: 19778847
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Hypersensitivity reactions.
Weiss RB
Semin Oncol 1992 Oct;19(5):458-77. PMID: 1384149

Prognosis

Hairy Cell Leukemia: Where Are We in 2023?
Mendez-Hernandez A, Moturi K, Hanson V, Andritsos LA
Curr Oncol Rep 2023 Aug;25(8):833-840. Epub 2023 Apr 25 doi: 10.1007/s11912-023-01419-z. PMID: 37097545Free PMC Article
Hairy Cell Leukaemia.
Cross M, Dearden C
Curr Oncol Rep 2020 Apr 16;22(5):42. doi: 10.1007/s11912-020-00911-0. PMID: 32297104
T-cell prolymphocytic leukemia.
Dearden CE
Clin Lymphoma Myeloma 2009;9 Suppl 3:S239-43. doi: 10.3816/CLM.2009.s.018. PMID: 19778847
Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
Curr Treat Options Oncol 2005 May;6(3):197-208. doi: 10.1007/s11864-005-0003-4. PMID: 15869731
Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention.
Pai VB, Nahata MC
Drug Saf 2000 Apr;22(4):263-302. doi: 10.2165/00002018-200022040-00002. PMID: 10789823

Clinical prediction guides

Reduced-intensity conditioning-based hematopoietic cell transplantation for dyskeratosis congenita: Single-center experience and literature review.
Bhoopalan SV, Wlodarski M, Reiss U, Triplett B, Sharma A
Pediatr Blood Cancer 2021 Oct;68(10):e29177. Epub 2021 Jun 4 doi: 10.1002/pbc.29177. PMID: 34086408
Cross-resistance and synergy with bendamustine in chronic lymphocytic leukemia.
Kost SE, Bouchard ED, LaBossière É, Ye X, Queau ML, Liang WS, Banerji V, Gibson SB, Katyal S, Johnston JB
Leuk Res 2016 Nov;50:63-71. Epub 2016 Sep 20 doi: 10.1016/j.leukres.2016.09.016. PMID: 27683974
Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS).
Li P, Huang P, Yang Y, Hao M, Peng H, Li F
Clin Rev Allergy Immunol 2016 Feb;50(1):55-63. doi: 10.1007/s12016-015-8466-y. PMID: 25663566
Modern strategies for hairy cell leukemia.
Grever MR, Lozanski G
J Clin Oncol 2011 Feb 10;29(5):583-90. Epub 2011 Jan 10 doi: 10.1200/JCO.2010.31.7016. PMID: 21220590
Treatment of hairy-cell leukemia.
Lill MC, Golde DW
Blood Rev 1990 Dec;4(4):238-44. doi: 10.1016/0268-960x(90)90003-b. PMID: 1706207

Recent systematic reviews

PEITC in End-Stage B-Cell Prolymphocytic Leukemia: Case Report of Possible Sensitization to Salvage R-CHOP.
Nachat A, Turoff-Ortmeyer S, Liu C, Mcculloch M
Perm J 2016 Spring;20(2):74-80. doi: 10.7812/TPP/15-153. PMID: 27168399Free PMC Article
Purine antagonists for chronic lymphocytic leukaemia.
Steurer M, Pall G, Richards S, Schwarzer G, Bohlius J, Greil R
Cochrane Database Syst Rev 2006 Jul 19;2006(3):CD004270. doi: 10.1002/14651858.CD004270.pub2. PMID: 16856041Free PMC Article
Single-agent purine analogues for the treatment of chronic lymphocytic leukaemia: a systematic review and meta-analysis.
Steurer M, Pall G, Richards S, Schwarzer G, Bohlius J, Greil R; Cochrane Haematologic Malignancies Group
Cancer Treat Rev 2006 Aug;32(5):377-89. Epub 2006 Jun 21 doi: 10.1016/j.ctrv.2006.05.002. PMID: 16793209

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