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Mildly Abnormal Ejection Fraction

MedGen UID:
476408
•Concept ID:
C3274775
•
Finding

Definition

Slightly less than normal amount of blood that is forced from the heart ventricle to produce cardiac output. Quantitatively, the ejection fraction is considered between 40% to 49%. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMildly Abnormal Ejection Fraction

Professional guidelines

PubMed

Contemporary pharmacological treatment and management of heart failure.
Bozkurt B
Nat Rev Cardiol 2024 Aug;21(8):545-555. Epub 2024 Mar 26 doi: 10.1038/s41569-024-00997-0. PMID: 38532020
Recent advances in the pharmacological therapy of chronic heart failure: Evidence and guidelines.
Tsutsui H
Pharmacol Ther 2022 Oct;238:108185. Epub 2022 Apr 9 doi: 10.1016/j.pharmthera.2022.108185. PMID: 35413307
Treatment of essential hypertension today. The role of beta blockers, calcium antagonists, and ACE inhibitors.
Lund-Johansen P
Med Clin North Am 1987 Sep;71(5):947-57. doi: 10.1016/s0025-7125(16)30819-7. PMID: 2887720

Recent clinical studies

Etiology

Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association.
Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, Anker SD, Atherton J, Böhm M, Butler J, Drazner MH, Michael Felker G, Filippatos G, Fiuzat M, Fonarow GC, Gomez-Mesa JE, Heidenreich P, Imamura T, Jankowska EA, Januzzi J, Khazanie P, Kinugawa K, Lam CSP, Matsue Y, Metra M, Ohtani T, Francesco Piepoli M, Ponikowski P, Rosano GMC, Sakata Y, Seferović P, Starling RC, Teerlink JR, Vardeny O, Yamamoto K, Yancy C, Zhang J, Zieroth S
Eur J Heart Fail 2021 Mar;23(3):352-380. Epub 2021 Mar 3 doi: 10.1002/ejhf.2115. PMID: 33605000
Young man presenting with out-of-hospital cardiac arrest.
Huang HD, Lombardi WL, Steinberg ZL
Heart 2018 Nov;104(21):1771-1802. Epub 2018 Jun 22 doi: 10.1136/heartjnl-2018-312966. PMID: 29934370
Cardiac MRI assessment of right ventricular function: impact of right bundle branch block on the evaluation of cardiac performance parameters.
Marterer R, Hongchun Z, Tschauner S, Koestenberger M, Sorantin E
Eur Radiol 2015 Dec;25(12):3528-35. Epub 2015 Jul 2 doi: 10.1007/s00330-015-3788-y. PMID: 26134997
Abnormal coronary microvascular endothelial function in humans with asymptomatic left ventricular dysfunction.
Prasad A, Higano ST, Al Suwaidi J, Holmes DR Jr, Mathew V, Pumper G, Lennon RJ, Lerman A
Am Heart J 2003 Sep;146(3):549-54. doi: 10.1016/S0002-8703(03)00364-8. PMID: 12947377
Treatment of essential hypertension today. The role of beta blockers, calcium antagonists, and ACE inhibitors.
Lund-Johansen P
Med Clin North Am 1987 Sep;71(5):947-57. doi: 10.1016/s0025-7125(16)30819-7. PMID: 2887720

Diagnosis

Recurrent Spontaneous Coronary Artery Dissection Presenting with STEMI, Once is Never Enough!
Al Emam AR, Akkad H, Asawaeer M, Pompili V
Curr Cardiol Rev 2021;17(4):e310521172093. doi: 10.2174/1573403X15666190513101614. PMID: 31092182Free PMC Article
Case series: LMNA-related dilated cardiomyopathy presents with reginal wall akinesis and transmural late gadolinium enhancement.
Wang S, Peng D
ESC Heart Fail 2020 Oct;7(5):3179-3183. Epub 2020 Jul 14 doi: 10.1002/ehf2.12822. PMID: 32666643Free PMC Article
Young man presenting with out-of-hospital cardiac arrest.
Huang HD, Lombardi WL, Steinberg ZL
Heart 2018 Nov;104(21):1771-1802. Epub 2018 Jun 22 doi: 10.1136/heartjnl-2018-312966. PMID: 29934370
Exercise-induced left ventricular systolic dysfunction in women heterozygous for dystrophinopathy.
Weiss RM, Kerber RE, Jones JK, Stephan CM, Trout CJ, Lindower PD, Staffey KS, Campbell KP, Mathews KD
J Am Soc Echocardiogr 2010 Aug;23(8):848-53. Epub 2010 Jun 19 doi: 10.1016/j.echo.2010.05.007. PMID: 20646909Free PMC Article
Treatment of essential hypertension today. The role of beta blockers, calcium antagonists, and ACE inhibitors.
Lund-Johansen P
Med Clin North Am 1987 Sep;71(5):947-57. doi: 10.1016/s0025-7125(16)30819-7. PMID: 2887720

Therapy

Low Natriuretic Peptide Levels and Outcomes in Patients With Heart Failure and Preserved Ejection Fraction.
Kondo T, Campbell R, Jhund PS, Anand IS, Carson PE, Lam CSP, Shah SJ, Vaduganathan M, Zannad F, Zile MR, Solomon SD, McMurray JJV
JACC Heart Fail 2024 Aug;12(8):1442-1455. Epub 2024 Jun 19 doi: 10.1016/j.jchf.2024.04.027. PMID: 38904646
Contemporary pharmacological treatment and management of heart failure.
Bozkurt B
Nat Rev Cardiol 2024 Aug;21(8):545-555. Epub 2024 Mar 26 doi: 10.1038/s41569-024-00997-0. PMID: 38532020
Autonomic regulation therapy in chronic heart failure with preserved/mildly reduced ejection fraction: ANTHEM-HFpEF study results.
Kumar HU, Nearing BD, Mittal S, Premchand RK, Libbus I, DiCarlo LA, Amurthur B, KenKnight BH, Anand IS, Verrier RL
Int J Cardiol 2023 Jun 15;381:37-44. Epub 2023 Mar 17 doi: 10.1016/j.ijcard.2023.03.030. PMID: 36934987
Recent advances in the pharmacological therapy of chronic heart failure: Evidence and guidelines.
Tsutsui H
Pharmacol Ther 2022 Oct;238:108185. Epub 2022 Apr 9 doi: 10.1016/j.pharmthera.2022.108185. PMID: 35413307
Treatment of essential hypertension today. The role of beta blockers, calcium antagonists, and ACE inhibitors.
Lund-Johansen P
Med Clin North Am 1987 Sep;71(5):947-57. doi: 10.1016/s0025-7125(16)30819-7. PMID: 2887720

Prognosis

Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association.
Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, Anker SD, Atherton J, Böhm M, Butler J, Drazner MH, Michael Felker G, Filippatos G, Fiuzat M, Fonarow GC, Gomez-Mesa JE, Heidenreich P, Imamura T, Jankowska EA, Januzzi J, Khazanie P, Kinugawa K, Lam CSP, Matsue Y, Metra M, Ohtani T, Francesco Piepoli M, Ponikowski P, Rosano GMC, Sakata Y, Seferović P, Starling RC, Teerlink JR, Vardeny O, Yamamoto K, Yancy C, Zhang J, Zieroth S
Eur J Heart Fail 2021 Mar;23(3):352-380. Epub 2021 Mar 3 doi: 10.1002/ejhf.2115. PMID: 33605000
Young man presenting with out-of-hospital cardiac arrest.
Huang HD, Lombardi WL, Steinberg ZL
Heart 2018 Nov;104(21):1771-1802. Epub 2018 Jun 22 doi: 10.1136/heartjnl-2018-312966. PMID: 29934370
Cardiac MRI assessment of right ventricular function: impact of right bundle branch block on the evaluation of cardiac performance parameters.
Marterer R, Hongchun Z, Tschauner S, Koestenberger M, Sorantin E
Eur Radiol 2015 Dec;25(12):3528-35. Epub 2015 Jul 2 doi: 10.1007/s00330-015-3788-y. PMID: 26134997
Abnormal coronary microvascular endothelial function in humans with asymptomatic left ventricular dysfunction.
Prasad A, Higano ST, Al Suwaidi J, Holmes DR Jr, Mathew V, Pumper G, Lennon RJ, Lerman A
Am Heart J 2003 Sep;146(3):549-54. doi: 10.1016/S0002-8703(03)00364-8. PMID: 12947377
Prognostic importance of atrial natriuretic peptide in patients with chronic heart failure.
Gottlieb SS, Kukin ML, Ahern D, Packer M
J Am Coll Cardiol 1989 Jun;13(7):1534-9. doi: 10.1016/0735-1097(89)90344-6. PMID: 2524515

Clinical prediction guides

The Clinical Evolution of Diffuse Myocardial Fibrosis in Patients With Arterial Hypertension and Heart Failure With Mildly Reduced Ejection Fraction Treated by Olmesartan or Sacubitril / Valsartan.
Shulzhenko LV, Pershukov IV, Batyraliev TA, Karben ZA, Gurovich OV, Fettser DV, Kuznetsova TN, Ivanenkova EY, Akbalaeva BA, Rayimbek Uulu N N, Toygonbaev S, Mansharipova AT, Seidalin AO, Zyablova EI, Kalmatov RK, Imetova ZB, Vinogradskaia VV, Gaydukova EV
Kardiologiia 2023 Dec 26;63(12):31-38. doi: 10.18087/cardio.2023.12.n2557. PMID: 38156487
Left ventricular function and coronary microcirculation in patients with mild reduced ejection fraction after STEMI.
Ma Y, Wang L, Jin W, Zhu T, Liu J, Zhao H, Wang J, Lu M, Cao C, Jiang B
BMC Cardiovasc Disord 2022 Sep 25;22(1):423. doi: 10.1186/s12872-022-02846-9. PMID: 36154928Free PMC Article
5-Fluorouracil-induced Tako-Tsubo-like syndrome.
Basselin C, Fontanges T, Descotes J, Chevalier P, Bui-Xuan B, Feinard G, Timour Q
Pharmacotherapy 2011 Feb;31(2):226. doi: 10.1592/phco.31.2.226. PMID: 21275498
Abnormal coronary microvascular endothelial function in humans with asymptomatic left ventricular dysfunction.
Prasad A, Higano ST, Al Suwaidi J, Holmes DR Jr, Mathew V, Pumper G, Lennon RJ, Lerman A
Am Heart J 2003 Sep;146(3):549-54. doi: 10.1016/S0002-8703(03)00364-8. PMID: 12947377
Radionuclide ejection fractions in the evaluation of patients being considered for bone marrow transplantation: risk for cardiac toxicity.
Bearman SI, Petersen FB, Schor RA, Denney JD, Fisher LD, Appelbaum FR, Buckner CD
Bone Marrow Transplant 1990 Mar;5(3):173-7. PMID: 2331537

Recent systematic reviews

Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review.
Gianni M, Dentali F, Grandi AM, Sumner G, Hiralal R, Lonn E
Eur Heart J 2006 Jul;27(13):1523-9. Epub 2006 May 23 doi: 10.1093/eurheartj/ehl032. PMID: 16720686

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