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  • The following term was not found in MedGen: @JYP24.

Neonatal period electroclinical syndrome

MedGen UID:
1054385
•Concept ID:
CN377686
•
Disease or Syndrome
Synonym: neonatal period electroclinical syndrome
 
Monarch Initiative: MONDO:0000412

Definition

An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age. [from MONDO]

Professional guidelines

PubMed

CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients.
Le Roux M, Barth M, Gueden S, Desbordes de Cepoy P, Aeby A, Vilain C, Hirsch E, de Saint Martin A, Portes VD, Lesca G, Riquet A, Chaton L, Villeneuve N, Villard L, Cances C, Valton L, Renaldo F, Vermersch AI, Altuzarra C, Nguyen-Morel MA, Van Gils J, Angelini C, Biraben A, Arnaud L, Riant F, Van Bogaert P
Eur J Paediatr Neurol 2021 Jul;33:75-85. Epub 2021 May 26 doi: 10.1016/j.ejpn.2021.05.010. PMID: 34102571

Recent clinical studies

Etiology

Genotype-phenotype correlates of infantile-onset developmental & epileptic encephalopathy syndromes in South India: A single centre experience.
Mitta N, Menon RN, McTague A, Radhakrishnan A, Sundaram S, Cherian A, Madhavilatha GK, Mannan AU, Nampoothiri S, Thomas SV
Epilepsy Res 2020 Oct;166:106398. Epub 2020 Jun 18 doi: 10.1016/j.eplepsyres.2020.106398. PMID: 32593896
Seizures in Children With Cerebral Palsy and White Matter Injury.
Cooper MS, Mackay MT, Fahey M, Reddihough D, Reid SM, Williams K, Harvey AS
Pediatrics 2017 Mar;139(3) Epub 2017 Feb 16 doi: 10.1542/peds.2016-2975. PMID: 28209769
'Benign focal epilepsy in infancy with vertex spikes and waves during sleep'. Delineation of the syndrome and recalling as 'benign infantile focal epilepsy with midline spikes and waves during sleep' (BIMSE).
Capovilla G, Beccaria F, Montagnini A
Brain Dev 2006 Mar;28(2):85-91. Epub 2005 Jun 20 doi: 10.1016/j.braindev.2005.05.001. PMID: 15967619
Epilepsy in peroxisomal diseases.
Takahashi Y, Suzuki Y, Kumazaki K, Tanabe Y, Akaboshi S, Miura K, Shimozawa N, Kondo N, Nishiguchi T, Terada K, Orii T
Epilepsia 1997 Feb;38(2):182-8. doi: 10.1111/j.1528-1157.1997.tb01095.x. PMID: 9048670
Early infantile epileptic encephalopathy: a long-term follow-up study.
Verrotti A, Domizio S, Sabatino G, Morgese G
Childs Nerv Syst 1996 Sep;12(9):530-3. doi: 10.1007/BF00261606. PMID: 8906368

Diagnosis

Epilepsy syndromes in cerebral palsy: varied, evolving and mostly self-limited.
Cooper MS, Mackay MT, Dagia C, Fahey MC, Howell KB, Reddihough D, Reid S, Harvey AS
Brain 2023 Feb 13;146(2):587-599. doi: 10.1093/brain/awac274. PMID: 35871494
Diagnostic Approach to Genetic Causes of Early-Onset Epileptic Encephalopathy.
Gürsoy S, Erçal D
J Child Neurol 2016 Mar;31(4):523-32. Epub 2015 Aug 13 doi: 10.1177/0883073815599262. PMID: 26271793
Long-term EEG in children.
Montavont A, Kaminska A, Soufflet C, Taussig D
Neurophysiol Clin 2015 Mar;45(1):81-5. Epub 2015 Jan 15 doi: 10.1016/j.neucli.2014.11.009. PMID: 25687590
Epilepsies and epileptic syndromes starting in the neonatal period.
Yamamoto H, Okumura A, Fukuda M
Brain Dev 2011 Mar;33(3):213-20. Epub 2010 Nov 9 doi: 10.1016/j.braindev.2010.10.009. PMID: 21067877
Epilepsy in peroxisomal diseases.
Takahashi Y, Suzuki Y, Kumazaki K, Tanabe Y, Akaboshi S, Miura K, Shimozawa N, Kondo N, Nishiguchi T, Terada K, Orii T
Epilepsia 1997 Feb;38(2):182-8. doi: 10.1111/j.1528-1157.1997.tb01095.x. PMID: 9048670

Therapy

Clinical characteristics of KCNQ2 encephalopathy.
Kim HJ, Yang D, Kim SH, Won D, Kim HD, Lee JS, Choi JR, Lee ST, Kang HC
Brain Dev 2021 Feb;43(2):244-250. Epub 2020 Sep 8 doi: 10.1016/j.braindev.2020.08.015. PMID: 32917465
Treating Infantile Spasms with High-Dose Oral Corticosteroids: A Retrospective Review of 87 Children.
Gonzalez-Giraldo E, Stafstrom CE, Stanfield AC, Kossoff EH
Pediatr Neurol 2018 Oct;87:30-35. Epub 2018 Aug 3 doi: 10.1016/j.pediatrneurol.2018.06.011. PMID: 30501887
Seizures in Children With Cerebral Palsy and White Matter Injury.
Cooper MS, Mackay MT, Fahey M, Reddihough D, Reid SM, Williams K, Harvey AS
Pediatrics 2017 Mar;139(3) Epub 2017 Feb 16 doi: 10.1542/peds.2016-2975. PMID: 28209769
Epilepsy in peroxisomal diseases.
Takahashi Y, Suzuki Y, Kumazaki K, Tanabe Y, Akaboshi S, Miura K, Shimozawa N, Kondo N, Nishiguchi T, Terada K, Orii T
Epilepsia 1997 Feb;38(2):182-8. doi: 10.1111/j.1528-1157.1997.tb01095.x. PMID: 9048670
Early infantile epileptic encephalopathy: a long-term follow-up study.
Verrotti A, Domizio S, Sabatino G, Morgese G
Childs Nerv Syst 1996 Sep;12(9):530-3. doi: 10.1007/BF00261606. PMID: 8906368

Prognosis

Epilepsy syndromes in cerebral palsy: varied, evolving and mostly self-limited.
Cooper MS, Mackay MT, Dagia C, Fahey MC, Howell KB, Reddihough D, Reid S, Harvey AS
Brain 2023 Feb 13;146(2):587-599. doi: 10.1093/brain/awac274. PMID: 35871494
Clinical characteristics of KCNQ2 encephalopathy.
Kim HJ, Yang D, Kim SH, Won D, Kim HD, Lee JS, Choi JR, Lee ST, Kang HC
Brain Dev 2021 Feb;43(2):244-250. Epub 2020 Sep 8 doi: 10.1016/j.braindev.2020.08.015. PMID: 32917465
Genotype-phenotype correlates of infantile-onset developmental & epileptic encephalopathy syndromes in South India: A single centre experience.
Mitta N, Menon RN, McTague A, Radhakrishnan A, Sundaram S, Cherian A, Madhavilatha GK, Mannan AU, Nampoothiri S, Thomas SV
Epilepsy Res 2020 Oct;166:106398. Epub 2020 Jun 18 doi: 10.1016/j.eplepsyres.2020.106398. PMID: 32593896
Seizures in Children With Cerebral Palsy and White Matter Injury.
Cooper MS, Mackay MT, Fahey M, Reddihough D, Reid SM, Williams K, Harvey AS
Pediatrics 2017 Mar;139(3) Epub 2017 Feb 16 doi: 10.1542/peds.2016-2975. PMID: 28209769
Epilepsy in Punjab (India): A Population-Based Epidemiologic Study.
Hara HS, Gupta A, Singh M, Raj R, Singh H, Pawar G, Hara PK, Singh J
Neuroepidemiology 2015;45(4):273-81. Epub 2015 Oct 27 doi: 10.1159/000438509. PMID: 26501478

Clinical prediction guides

Genotype-phenotype correlates of infantile-onset developmental & epileptic encephalopathy syndromes in South India: A single centre experience.
Mitta N, Menon RN, McTague A, Radhakrishnan A, Sundaram S, Cherian A, Madhavilatha GK, Mannan AU, Nampoothiri S, Thomas SV
Epilepsy Res 2020 Oct;166:106398. Epub 2020 Jun 18 doi: 10.1016/j.eplepsyres.2020.106398. PMID: 32593896
Long-term EEG in children.
Montavont A, Kaminska A, Soufflet C, Taussig D
Neurophysiol Clin 2015 Mar;45(1):81-5. Epub 2015 Jan 15 doi: 10.1016/j.neucli.2014.11.009. PMID: 25687590
Epilepsies and epileptic syndromes starting in the neonatal period.
Yamamoto H, Okumura A, Fukuda M
Brain Dev 2011 Mar;33(3):213-20. Epub 2010 Nov 9 doi: 10.1016/j.braindev.2010.10.009. PMID: 21067877
'Benign focal epilepsy in infancy with vertex spikes and waves during sleep'. Delineation of the syndrome and recalling as 'benign infantile focal epilepsy with midline spikes and waves during sleep' (BIMSE).
Capovilla G, Beccaria F, Montagnini A
Brain Dev 2006 Mar;28(2):85-91. Epub 2005 Jun 20 doi: 10.1016/j.braindev.2005.05.001. PMID: 15967619
Epileptic negative myoclonus in a newborn with hemimegalencephaly.
Guzzetta F, Battaglia D, Lettori D, Deodato F, Sani E, Randò T, Ricci D, Acquafondata C, Faienza C
Epilepsia 2002 Sep;43(9):1106-9. doi: 10.1046/j.1528-1157.2002.15001.x. PMID: 12199738

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