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Coccidioidomycosis

MedGen UID:
3137
•Concept ID:
C0009186
•
Disease or Syndrome
Synonyms: Coccidioides immitis infection; San Joaquin fever; Valley fever
SNOMED CT: Coccidioidomycosis (60826002); Posadas-Wernicke disease (60826002); Coccidioidomycosis infection (60826002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0032249
Monarch Initiative: MONDO:0005706
Orphanet: ORPHA228123

Definition

Infection by a Coccidioides species fungus. These are dimorphic, soil-dwelling, fungi known to cause a broad spectrum of disease, ranging from a mild febrile illness to severe pulmonary manifestations or disseminated disease. The genus Coccidioides is comprised of two genetically distinct species [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCoccidioidomycosis
Follow this link to review classifications for Coccidioidomycosis in Orphanet.

Conditions with this feature

Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome
MedGen UID:
481620
•Concept ID:
C3279990
•
Disease or Syndrome
IMD31C is a disorder of immunologic dysregulation with highly variable manifestations resulting from autosomal dominant gain-of-function mutations in STAT1 (600555). Most patients present in infancy or early childhood with chronic mucocutaneous candidiasis (CMC). Other highly variable features include recurrent bacterial, viral, fungal, and mycoplasmal infections, disseminated dimorphic fungal infections, enteropathy with villous atrophy, and autoimmune disorders, such as hypothyroidism or diabetes mellitus. A subset of patients show apparently nonimmunologic features, including osteopenia, delayed puberty, and intracranial aneurysms. Laboratory studies show increased activation of gamma-interferon (IFNG; 147570)-mediated inflammation (summary by Uzel et al., 2013 and Sampaio et al., 2013).
See: Condition Record
Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome

Professional guidelines

PubMed

Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis.
Galgiani JN, Ampel NM, Blair JE, Catanzaro A, Geertsma F, Hoover SE, Johnson RH, Kusne S, Lisse J, MacDonald JD, Meyerson SL, Raksin PB, Siever J, Stevens DA, Sunenshine R, Theodore N
Clin Infect Dis 2016 Sep 15;63(6):e112-46. Epub 2016 Jul 27 doi: 10.1093/cid/ciw360. PMID: 27470238
An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group
Am J Respir Crit Care Med 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST. PMID: 21193785

Recent clinical studies

Etiology

The Geographic Distribution of Dimorphic Mycoses in the United States for the Modern Era.
Mazi PB, Sahrmann JM, Olsen MA, Coler-Reilly A, Rauseo AM, Pullen M, Zuniga-Moya JC, Powderly WG, Spec A
Clin Infect Dis 2023 Apr 3;76(7):1295-1301. doi: 10.1093/cid/ciac882. PMID: 36366776Free PMC Article
North American Endemic Fungal Infections.
Kanne JP
Radiol Clin North Am 2022 May;60(3):409-427. doi: 10.1016/j.rcl.2022.01.007. PMID: 35534128
Occupational Respiratory Infections.
de Perio MA, Kobayashi M, Wortham JM
Clin Chest Med 2020 Dec;41(4):739-751. doi: 10.1016/j.ccm.2020.08.003. PMID: 33153691Free PMC Article
Pulmonary Coccidioidomycosis.
Kimes KE, Kasule SN, Blair JE
Semin Respir Crit Care Med 2020 Feb;41(1):42-52. Epub 2020 Jan 30 doi: 10.1055/s-0039-3400998. PMID: 32000283
Coccidioidomycosis in Latin America.
Laniado-Laborín R, Arathoon EG, Canteros C, Muñiz-Salazar R, Rendon A
Med Mycol 2019 Feb 1;57(Supplement_1):S46-S55. doi: 10.1093/mmy/myy037. PMID: 30690597

Diagnosis

Coccidioidomycosis and Histoplasmosis in Immunocompetent Persons.
Galgiani JN, Kauffman CA
N Engl J Med 2024 Feb 8;390(6):536-547. doi: 10.1056/NEJMra2306821. PMID: 38324487
Coccidioidomycosis.
Bays DJ, Thompson GR 3rd
Infect Dis Clin North Am 2021 Jun;35(2):453-469. doi: 10.1016/j.idc.2021.03.010. PMID: 34016286
Coccidioidomycosis: a review.
Johnson RH, Sharma R, Kuran R, Fong I, Heidari A
J Investig Med 2021 Feb;69(2):316-323. doi: 10.1136/jim-2020-001655. PMID: 33495302Free PMC Article
Pulmonary Coccidioidomycosis.
Kimes KE, Kasule SN, Blair JE
Semin Respir Crit Care Med 2020 Feb;41(1):42-52. Epub 2020 Jan 30 doi: 10.1055/s-0039-3400998. PMID: 32000283
Coccidioidomycosis.
Stockamp NW, Thompson GR 3rd
Infect Dis Clin North Am 2016 Mar;30(1):229-46. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.008. PMID: 26739609

Therapy

Coccidioidomycosis.
Bays DJ, Thompson GR 3rd
Infect Dis Clin North Am 2021 Jun;35(2):453-469. doi: 10.1016/j.idc.2021.03.010. PMID: 34016286
Coccidioidomycosis: a review.
Johnson RH, Sharma R, Kuran R, Fong I, Heidari A
J Investig Med 2021 Feb;69(2):316-323. doi: 10.1136/jim-2020-001655. PMID: 33495302Free PMC Article
Coccidioidomycosis.
Stockamp NW, Thompson GR 3rd
Infect Dis Clin North Am 2016 Mar;30(1):229-46. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.008. PMID: 26739609
Coccidioidomycosis.
Welsh O, Vera-Cabrera L, Rendon A, Gonzalez G, Bonifaz A
Clin Dermatol 2012 Nov-Dec;30(6):573-91. doi: 10.1016/j.clindermatol.2012.01.003. PMID: 23068145
Coccidioidomycosis.
Parish JM, Blair JE
Mayo Clin Proc 2008 Mar;83(3):343-48; quiz 348-9. doi: 10.4065/83.3.343. PMID: 18316002

Prognosis

Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Pulmonary Coccidioidomycosis.
Kimes KE, Kasule SN, Blair JE
Semin Respir Crit Care Med 2020 Feb;41(1):42-52. Epub 2020 Jan 30 doi: 10.1055/s-0039-3400998. PMID: 32000283
Coccidioidomycosis.
Stockamp NW, Thompson GR 3rd
Infect Dis Clin North Am 2016 Mar;30(1):229-46. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.008. PMID: 26739609
Coccidioidomycosis.
Welsh O, Vera-Cabrera L, Rendon A, Gonzalez G, Bonifaz A
Clin Dermatol 2012 Nov-Dec;30(6):573-91. doi: 10.1016/j.clindermatol.2012.01.003. PMID: 23068145
Coccidioidomycosis.
Parish JM, Blair JE
Mayo Clin Proc 2008 Mar;83(3):343-48; quiz 348-9. doi: 10.4065/83.3.343. PMID: 18316002

Clinical prediction guides

Endemic mycoses - are we making progress in management?
Bahr NC, Thompson GR 3rd
Curr Opin Infect Dis 2023 Dec 1;36(6):436-442. Epub 2023 Sep 26 doi: 10.1097/QCO.0000000000000971. PMID: 37755392Free PMC Article
Cross-Sectional Study of Clinical Predictors of Coccidioidomycosis, Arizona, USA.
Ramadan FA, Ellingson KD, Canales RA, Bedrick EJ, Galgiani JN, Donovan FM
Emerg Infect Dis 2022 Jun;28(6):1091-1100. doi: 10.3201/eid2806.212311. PMID: 35608552Free PMC Article
Epidemiology, Clinical Features, and Outcomes of Coccidioidomycosis, Utah, 2006-2015.
Carey A, Gorris ME, Chiller T, Jackson B, Beadles W, Webb BJ
Emerg Infect Dis 2021 Sep;27(9):2269-2277. doi: 10.3201/eid2709.210751. PMID: 34423764Free PMC Article
Primary Cutaneous Coccidioidomycosis: An Update.
Reyna-Rodríguez IL, Ocampo-Candiani J, Chavez-Alvarez S
Am J Clin Dermatol 2020 Oct;21(5):681-696. doi: 10.1007/s40257-020-00525-z. PMID: 32557380
Coccidioidomycosis: Recent Updates.
Twarog M, Thompson GR 3rd
Semin Respir Crit Care Med 2015 Oct;36(5):746-55. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562900. PMID: 26398540

Recent systematic reviews

Talaromyces marneffei, Coccidioides species, and Paracoccidioides species-a systematic review to inform the World Health Organization priority list of fungal pathogens.
Morris AJ, Kim HY, Nield B, Dao A, McMullan B, Alastruey-Izquierdo A, Colombo AL, Heim J, Wahyuningsih R, Le T, Chiller TM, Forastiero A, Chakrabarti A, Harrison TS, Bongomin F, Galas M, Siswanto S, Dagne DA, Roitberg F, Gigante V, Beardsley J, Sati H, Alffenaar JW, Morrissey CO
Med Mycol 2024 Jun 27;62(6) doi: 10.1093/mmy/myad133. PMID: 38935909Free PMC Article
Endemic Systemic Mycoses in Italy: A Systematic Review of Literature and a Practical Update.
Zerbato V, Di Bella S, Pol R, D'Aleo F, Angheben A, Farina C, Conte M, Luzzaro F; Gianluigi Lombardi on behalf of the AMCLI Mycology Committee, Luzzati R, Principe L
Mycopathologia 2023 Aug;188(4):307-334. Epub 2023 Jun 9 doi: 10.1007/s11046-023-00735-z. PMID: 37294504Free PMC Article
Infectious Diseases Associated with Desert Dust Outbreaks: A Systematic Review.
Vergadi E, Rouva G, Angeli M, Galanakis E
Int J Environ Res Public Health 2022 Jun 5;19(11) doi: 10.3390/ijerph19116907. PMID: 35682493Free PMC Article
Cerebrovascular complications of coccidioidomycosis meningitis: Case report and systematic review.
Phelps RRL, Lu AY, Lee AT, Yue JK, Winkler EA, Raygor KP, Oh T, Barkovich MJ, Hollander H
J Clin Neurosci 2020 Oct;80:282-289. Epub 2020 Oct 2 doi: 10.1016/j.jocn.2020.08.007. PMID: 33099362
Diagnosis of Fungal Infections. A Systematic Review and Meta-Analysis Supporting American Thoracic Society Practice Guideline.
Haydour Q, Hage CA, Carmona EM, Epelbaum O, Evans SE, Gabe LM, Knox KS, Kolls JK, Wengenack NL, Prokop LJ, Limper AH, Murad MH
Ann Am Thorac Soc 2019 Sep;16(9):1179-1188. doi: 10.1513/AnnalsATS.201811-766OC. PMID: 31219341

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