U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rickettsialpox

MedGen UID:
19803
Concept ID:
C0035597
Disease or Syndrome
Synonyms: Infection, Rickettsia akari; Infections, Rickettsia akari; Rickettsia akari Infection; Rickettsia akari Infections
SNOMED CT: Rickettsialpox (75096007); Vesicular rickettsiosis (75096007); Rickettsialpox due to Rickettsia akari (75096007); Kew Gardens spotted fever (75096007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019360
Orphanet: ORPHA83312

Definition

A rare, acquired, self-limiting, infectious disease due to the mite-borne bacteria <i>Rickettsia akari</i> characterized by an asymptomatic, 0.5 to 2 cm in diameter papulovesicle that typically ulcerates and forms an eschar, followed by a generalized papulovesicular rash associating variable constitutional symptoms, such as localized lymphadenopathy, fever, malaise, and headaches. Additonal symptoms may include diaphoresis, myalgia and, less frequently, rhinorrhea, pharyngitis, nausea, vomiting, splenomegaly, conjunctival hyperemia, and abdominal pain. Systemic symptoms resolve within 6-10 days. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRickettsialpox
Follow this link to review classifications for Rickettsialpox in Orphanet.

Professional guidelines

PubMed

ROSE HM
Ann N Y Acad Sci 1952 Dec 30;55(6):1019-26. doi: 10.1111/j.1749-6632.1952.tb22661.x. PMID: 13139180
REISS F
Dermatologica 1949;99(1):33-43. PMID: 18148043

Recent clinical studies

Etiology

Csicsay F, Flores-Ramirez G, Zuñiga-Navarrete F, Bartošová M, Fučíková A, Pajer P, Dresler J, Škultéty Ľ, Quevedo-Diaz M
BMC Microbiol 2020 Jul 8;20(1):200. doi: 10.1186/s12866-020-01877-6. PMID: 32640994Free PMC Article
Vyas NS, Shieh WJ, Phelps RG
J Cutan Pathol 2020 May;47(5):451-458. Epub 2020 Feb 3 doi: 10.1111/cup.13649. PMID: 31955452
Portillo A, Santibáñez S, García-Álvarez L, Palomar AM, Oteo JA
Microbes Infect 2015 Nov-Dec;17(11-12):834-8. Epub 2015 Sep 16 doi: 10.1016/j.micinf.2015.09.009. PMID: 26384814
Paddock CD, Zaki SR, Koss T, Singleton J Jr, Sumner JW, Comer JA, Eremeeva ME, Dasch GA, Cherry B, Childs JE
Ann N Y Acad Sci 2003 Jun;990:36-44. doi: 10.1111/j.1749-6632.2003.tb07334.x. PMID: 12860597
Boyd AS
Dermatol Clin 1997 Apr;15(2):313-8. doi: 10.1016/s0733-8635(05)70439-3. PMID: 9098640

Diagnosis

Vyas NS, Shieh WJ, Phelps RG
J Cutan Pathol 2020 May;47(5):451-458. Epub 2020 Feb 3 doi: 10.1111/cup.13649. PMID: 31955452
Hananiya A, Douglas LC, Fagan M
Pediatr Emerg Care 2017 Apr;33(4):260-262. doi: 10.1097/PEC.0000000000001088. PMID: 28353525
Portillo A, Santibáñez S, García-Álvarez L, Palomar AM, Oteo JA
Microbes Infect 2015 Nov-Dec;17(11-12):834-8. Epub 2015 Sep 16 doi: 10.1016/j.micinf.2015.09.009. PMID: 26384814
Brouqui P, Raoult D
Ann N Y Acad Sci 2006 Oct;1078:223-35. doi: 10.1196/annals.1374.041. PMID: 17114713
Boyd AS
Dermatol Clin 1997 Apr;15(2):313-8. doi: 10.1016/s0733-8635(05)70439-3. PMID: 9098640

Therapy

Imperato PJ, Imperato GH
J Community Health 2014 Aug;39(4):682-7. doi: 10.1007/s10900-014-9882-2. PMID: 24838855
Diaz JH
J La State Med Soc 2010 May-Jun;162(3):140-5, 147-9. PMID: 20666166
Saini R, Pui JC, Burgin S
J Am Acad Dermatol 2004 Nov;51(5 Suppl):S137-42. doi: 10.1016/j.jaad.2004.03.036. PMID: 15577753
Boyd AS
Dermatol Clin 1997 Apr;15(2):313-8. doi: 10.1016/s0733-8635(05)70439-3. PMID: 9098640
ROSE HM
Ann N Y Acad Sci 1952 Dec 30;55(6):1019-26. doi: 10.1111/j.1749-6632.1952.tb22661.x. PMID: 13139180

Prognosis

Bishop A, Borski J, Wang HH, Donaldson TG, Michalk A, Montgomery A, Heldman S, Mogg M, Derouen Z, Grant WE, Teel PD
Vector Borne Zoonotic Dis 2022 Sep;22(9):491-497. Epub 2022 Aug 26 doi: 10.1089/vbz.2022.0021. PMID: 36037000
Greene SK, Levin-Rector A, Hadler JL, Fine AD
Am J Public Health 2015 Sep;105(9):e27-34. Epub 2015 Jul 16 doi: 10.2105/AJPH.2015.302741. PMID: 26180961Free PMC Article
Ciceroni L, Pinto A, Ciarrocchi S, Ciervo A
Ann N Y Acad Sci 2006 Oct;1078:143-9. doi: 10.1196/annals.1374.024. PMID: 17114696
Boyd AS
Dermatol Clin 1997 Apr;15(2):313-8. doi: 10.1016/s0733-8635(05)70439-3. PMID: 9098640
Walker DH
J Dermatol 1989 Jun;16(3):169-77. doi: 10.1111/j.1346-8138.1989.tb01244.x. PMID: 2677080

Clinical prediction guides

Dzelalija B, Punda-Polic V, Medic A, Dobec M
Travel Med Infect Dis 2016 Sep-Oct;14(5):436-443. Epub 2016 Jul 9 doi: 10.1016/j.tmaid.2016.06.010. PMID: 27404664
Greene SK, Levin-Rector A, Hadler JL, Fine AD
Am J Public Health 2015 Sep;105(9):e27-34. Epub 2015 Jul 16 doi: 10.2105/AJPH.2015.302741. PMID: 26180961Free PMC Article
Koss T, Carter EL, Grossman ME, Silvers DN, Rabinowitz AD, Singleton J Jr, Zaki SR, Paddock CD
Arch Dermatol 2003 Dec;139(12):1545-52. doi: 10.1001/archderm.139.12.1545. PMID: 14676069
Wong B, Singer C, Armstrong D, Millian SJ
JAMA 1979 Nov 2;242(18):1998-9. doi: 10.1001/jama.242.18.1998. PMID: 480648
GREENBERG M, PELLITTERI O
J Am Med Assoc 1947 Mar 29;133(13):901-6. doi: 10.1001/jama.1947.02880130001001. PMID: 20288254

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...