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  • The following terms were not found in MedGen: Nitroquinoxalin, yl, 6-Nitroquinoxalin-2-yl, piperidin, piperidin-4-ol.

pentostatin

MedGen UID:
10633
•Concept ID:
C0030896
•
Antibiotic; Nucleic Acid, Nucleoside, or Nucleotide
Synonyms: 2' Deoxycoformycin; 2'-Deoxycoformycin; Deoxycoformycin; Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-; Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-; Pentostatin
SNOMED CT: Pentostatin (387154004); Deoxycoformycin (387154004); Pentostatin-containing product (28149003)
Drug response:
Pentostatin response
MedGen UID:
982456
•Concept ID:
CN298613
•
Sign or Symptom
Pentostatin response

Definition

A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2''-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04) [from NCI]

Professional guidelines

PubMed

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Recent clinical studies

Etiology

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Hypersensitivity reactions.
Weiss RB
Semin Oncol 1992 Oct;19(5):458-77. PMID: 1384149

Diagnosis

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Hairy cell leukemia.
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Therapy

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Hypersensitivity reactions.
Weiss RB
Semin Oncol 1992 Oct;19(5):458-77. PMID: 1384149

Prognosis

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Hairy Cell Leukaemia.
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Janus A, Robak T
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Prolymphocytic leukemia.
Absi A, Hsi E, Kalaycio M
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Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention.
Pai VB, Nahata MC
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Clinical prediction guides

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Rituximab plus fludarabine and cyclophosphamide or other agents in chronic lymphocytic leukemia.
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Treatment of hairy-cell leukemia.
Lill MC, Golde DW
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Recent systematic reviews

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