Spermatogenic failure 89(SPGF89)

MedGen UID:: 1852501
•Concept ID:: C5882752
•: Disease or Syndrome

Synonym:	SPGF89

Gene (location): Gene(s) directly associated with this condition or phenotype.	AK9 (6q21)

Monarch Initiative:	MONDO:0958206
OMIM®:	620705

Definition

Spermatogenic failure-89 (SPGF89) is characterized by male infertility due to severely reduced progressive motility of sperm (Sha et al., 2023). For a general phenotypic description and discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

Recent clinical studies

Clinical prediction guides

Association of MSY haplotype background with nonobstructive azoospermia is AZF-dependent: A case-control study.

Seyedin A, Kazeroun MH, Namipashaki A, Qobadi-Nasr S, Zamanian M, Ansari-Pour N
Andrologia 2021 Mar;53(2):e13946. Epub 2021 Jan 1 doi: 10.1111/and.13946. PMID: 33386637

Testis-Specific Y-Centric Protein-Protein Interaction Network Provides Clues to the Etiology of Severe Spermatogenic Failure.

Ansari-Pour N, Razaghi-Moghadam Z, Barneh F, Jafari M
J Proteome Res 2016 Mar 4;15(3):1011-22. Epub 2016 Feb 4 doi: 10.1021/acs.jproteome.5b01080. PMID: 26794825

Association of meiotic arrest with lack of BOULE protein expression in infertile men.

Luetjens CM, Xu EY, Rejo Pera RA, Kamischke A, Nieschlag E, Gromoll J
J Clin Endocrinol Metab 2004 Apr;89(4):1926-33. doi: 10.1210/jc.2003-031178. PMID: 15070965

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Spermatogenic failure 89(SPGF89)

Definition

Recent clinical studies

Clinical prediction guides

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