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  • The following term was not found in MedGen: coml.

Alpha 2u-Globulin Nephropathy

MedGen UID:
884326
•Concept ID:
C4055477
•
Disease or Syndrome
Synonym: Alpha 2mu-globulin Neuropathy

Definition

Increase in eosinophilic cytoplasmic droplets of alpha 2u-globulin in the S2 segment of the proximal tubules in the cortex with exfoliation of cells, an increase in mitotic figures in affected portions of the proximal tubules, tubular basophilia in some cases, and formation of granular casts at the junction of the inner and outer stripes of the medulla. (INHAND) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlpha 2u-Globulin Nephropathy

Professional guidelines

PubMed

An evaluation of the carcinogenic hazard of 1,4-dichlorobenzene based on internationally recognized criteria.
Barter JA, Sherman JH
Regul Toxicol Pharmacol 1999 Feb;29(1):64-79. doi: 10.1006/rtph.1998.1269. PMID: 10051419
Alpha 2u-globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment.
Swenberg JA
Environ Health Perspect 1993 Dec;101 Suppl 6(Suppl 6):39-44. doi: 10.1289/ehp.93101s639. PMID: 7517351Free PMC Article
Risk assessment of chemicals causing alpha 2u-globulin nephropathy.
Swenberg JA
Regul Toxicol Pharmacol 1991 Feb;13(1):1-2. doi: 10.1016/0273-2300(91)90037-v. PMID: 1708900

Recent clinical studies

Etiology

Modes of action of trichloroethylene for kidney tumorigenesis.
Lash LH, Parker JC, Scott CS
Environ Health Perspect 2000 May;108 Suppl 2(Suppl 2):225-40. doi: 10.1289/ehp.00108s2225. PMID: 10807554Free PMC Article
Alpha 2u-globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment.
Swenberg JA
Environ Health Perspect 1993 Dec;101 Suppl 6(Suppl 6):39-44. doi: 10.1289/ehp.93101s639. PMID: 7517351Free PMC Article
An alternative hypothesis on the role of chemically induced protein droplet (alpha 2u-globulin) nephropathy in renal carcinogenesis.
Melnick RL
Regul Toxicol Pharmacol 1992 Oct;16(2):111-25. doi: 10.1016/0273-2300(92)90052-b. PMID: 1279759
Risk assessment of chemicals causing alpha 2u-globulin nephropathy.
Swenberg JA
Regul Toxicol Pharmacol 1991 Feb;13(1):1-2. doi: 10.1016/0273-2300(91)90037-v. PMID: 1708900
Biochemical mechanisms and pathobiology of alpha 2u-globulin nephropathy.
Borghoff SJ, Short BG, Swenberg JA
Annu Rev Pharmacol Toxicol 1990;30:349-67. doi: 10.1146/annurev.pa.30.040190.002025. PMID: 1693054

Diagnosis

Methyl tertiary-butyl ether: studies for potential human health hazards.
McGregor D
Crit Rev Toxicol 2006 Apr;36(4):319-58. doi: 10.1080/10408440600569938. PMID: 16809102

Therapy

Tetrahydrofuran-induced tumors in rodents are not relevant to humans: Quantitative weight of evidence analysis of mode of action information does not support classification of tetrahydrofuran as a possible human carcinogen.
Dekant W
Regul Toxicol Pharmacol 2019 Dec;109:104499. Epub 2019 Oct 15 doi: 10.1016/j.yrtph.2019.104499. PMID: 31626827
Tertiary-Butanol: a toxicological review.
McGregor D
Crit Rev Toxicol 2010 Sep;40(8):697-727. doi: 10.3109/10408444.2010.494249. PMID: 20722584
Modes of action of trichloroethylene for kidney tumorigenesis.
Lash LH, Parker JC, Scott CS
Environ Health Perspect 2000 May;108 Suppl 2(Suppl 2):225-40. doi: 10.1289/ehp.00108s2225. PMID: 10807554Free PMC Article
Reducing uncertainty in risk assessment by using specific knowledge to replace default options.
McClellan RO
Drug Metab Rev 1996 Feb-May;28(1-2):149-79. doi: 10.3109/03602539608993997. PMID: 8744594

Prognosis

Tetrahydrofuran-induced tumors in rodents are not relevant to humans: Quantitative weight of evidence analysis of mode of action information does not support classification of tetrahydrofuran as a possible human carcinogen.
Dekant W
Regul Toxicol Pharmacol 2019 Dec;109:104499. Epub 2019 Oct 15 doi: 10.1016/j.yrtph.2019.104499. PMID: 31626827
Modes of action of trichloroethylene for kidney tumorigenesis.
Lash LH, Parker JC, Scott CS
Environ Health Perspect 2000 May;108 Suppl 2(Suppl 2):225-40. doi: 10.1289/ehp.00108s2225. PMID: 10807554Free PMC Article
An evaluation of the carcinogenic hazard of 1,4-dichlorobenzene based on internationally recognized criteria.
Barter JA, Sherman JH
Regul Toxicol Pharmacol 1999 Feb;29(1):64-79. doi: 10.1006/rtph.1998.1269. PMID: 10051419

Clinical prediction guides

Tertiary-Butanol: a toxicological review.
McGregor D
Crit Rev Toxicol 2010 Sep;40(8):697-727. doi: 10.3109/10408444.2010.494249. PMID: 20722584
Ethyl tertiary-butyl ether: a toxicological review.
McGregor D
Crit Rev Toxicol 2007 May;37(4):287-312. doi: 10.1080/10408440601177723. PMID: 17453936
Methyl tertiary-butyl ether: studies for potential human health hazards.
McGregor D
Crit Rev Toxicol 2006 Apr;36(4):319-58. doi: 10.1080/10408440600569938. PMID: 16809102
Hepatic and renal toxicities associated with perchloroethylene.
Lash LH, Parker JC
Pharmacol Rev 2001 Jun;53(2):177-208. PMID: 11356983
An evaluation of the carcinogenic hazard of 1,4-dichlorobenzene based on internationally recognized criteria.
Barter JA, Sherman JH
Regul Toxicol Pharmacol 1999 Feb;29(1):64-79. doi: 10.1006/rtph.1998.1269. PMID: 10051419

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