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Loose anagen hair syndrome

MedGen UID:
98351
•Concept ID:
C0406468
•
Disease or Syndrome
Synonym: Loose anagen syndrome
SNOMED CT: Loose anagen hair syndrome (238735005)
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
•Concept ID:
C0443147
•
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Autosomal dominant inheritance (Orphanet)
 
Monarch Initiative: MONDO:0010908
OMIM®: 600628
Orphanet: ORPHA168

Definition

Loose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoose anagen hair syndrome
Follow this link to review classifications for Loose anagen hair syndrome in Orphanet.

Professional guidelines

PubMed

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose.
Villani A, Fabbrocini G, Ocampo-Candiani J, Ruggiero A, Ocampo-Garza SS
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1485-1492. Epub 2021 Mar 23 doi: 10.1111/jdv.17216. PMID: 33660357
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136

Recent clinical studies

Therapy

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose.
Villani A, Fabbrocini G, Ocampo-Candiani J, Ruggiero A, Ocampo-Garza SS
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1485-1492. Epub 2021 Mar 23 doi: 10.1111/jdv.17216. PMID: 33660357
Oral minoxidil treatment for hair loss: A review of efficacy and safety.
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136
A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone.
Zhou P, Zhu L, Fan Q, Liu Y, Zhang T, Yang T, Chen J, Cheng Q, Li T, Chen L
Am J Med Genet A 2020 Aug;182(8):1967-1971. Epub 2020 Jun 1 doi: 10.1002/ajmg.a.61638. PMID: 32476286
Hair loss in children.
Alves R, Grimalt R
Curr Probl Dermatol 2015;47:55-66. Epub 2015 Feb 20 doi: 10.1159/000369405. PMID: 26370644
Coarctation of the aorta in Noonan-like syndrome with loose anagen hair.
Zmolikova M, Puchmajerova A, Hecht P, Lebl J, Trkova M, Krepelova A
Am J Med Genet A 2014 May;164A(5):1218-21. Epub 2014 Jan 23 doi: 10.1002/ajmg.a.36404. PMID: 24458596

Prognosis

Antenatal diagnosis of cardio-facio-cutaneous syndrome: Prenatal characteristics and contribution of fetal facial dysmorphic signs in utero. About a case and review of literature.
Biard JM, Steenhaut P, Bernard P, Race V, Sznajer Y
Eur J Obstet Gynecol Reprod Biol 2019 Sep;240:232-241. Epub 2019 Jul 16 doi: 10.1016/j.ejogrb.2019.06.035. PMID: 31336229
Loose Anagen Syndrome: A Retrospective Chart Review of 37 Cases.
Swink SM, Castelo-Soccio L
Pediatr Dermatol 2016 Sep;33(5):507-10. Epub 2016 Jul 19 doi: 10.1111/pde.12912. PMID: 27436070
Coarctation of the aorta in Noonan-like syndrome with loose anagen hair.
Zmolikova M, Puchmajerova A, Hecht P, Lebl J, Trkova M, Krepelova A
Am J Med Genet A 2014 May;164A(5):1218-21. Epub 2014 Jan 23 doi: 10.1002/ajmg.a.36404. PMID: 24458596
Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: an ultrastructural study.
Mirmirani P, Uno H, Price VH
J Am Acad Dermatol 2011 Jan;64(1):129-34. doi: 10.1016/j.jaad.2010.01.026. PMID: 21167408
Practical guidelines for evaluation of loose anagen hair syndrome.
Cantatore-Francis JL, Orlow SJ
Arch Dermatol 2009 Oct;145(10):1123-8. doi: 10.1001/archdermatol.2009.220. PMID: 19841399

Clinical prediction guides

Uncombable hair syndrome and beyond.
Alsabbagh MM
Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):49-64. PMID: 35751533
Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome.
Motta M, Solman M, Bonnard AA, Kuechler A, Pantaleoni F, Priolo M, Chandramouli B, Coppola S, Pizzi S, Zara E, Ferilli M, Kayserili H, Onesimo R, Leoni C, Brinkmann J, Vial Y, Kamphausen SB, Thomas-Teinturier C, Guimier A, Cordeddu V, Mazzanti L, Zampino G, Chillemi G, Zenker M, Cavé H, den Hertog J, Tartaglia M
Hum Mol Genet 2022 Aug 23;31(16):2766-2778. doi: 10.1093/hmg/ddac071. PMID: 35348676Free PMC Article
Hair loss in children.
Alves R, Grimalt R
Curr Probl Dermatol 2015;47:55-66. Epub 2015 Feb 20 doi: 10.1159/000369405. PMID: 26370644
Coarctation of the aorta in Noonan-like syndrome with loose anagen hair.
Zmolikova M, Puchmajerova A, Hecht P, Lebl J, Trkova M, Krepelova A
Am J Med Genet A 2014 May;164A(5):1218-21. Epub 2014 Jan 23 doi: 10.1002/ajmg.a.36404. PMID: 24458596
Loose anagen hair as a cause of hereditary hair loss in children.
Baden HP, Kvedar JC, Magro CM
Arch Dermatol 1992 Oct;128(10):1349-53. PMID: 1417022

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