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Nalidixic acid response

MedGen UID:
982233
•Concept ID:
CN298751
•
Sign or Symptom
Drug:
nalidixic acid
MedGen UID:
10174
•Concept ID:
C0027353
•
Antibiotic
A synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder and exerts its local antibacterial actions by interference of DNA gyrase activity, thereby inhibiting DNA synthesis during bacterial replication in a dose-dependent manner. Nalidixic acid is active against most gram-negative organisms that cause urinary tract infections. [from NCI]
nalidixic acid

Professional guidelines

PubMed

Efficacy of Ciprofloxacin for Treatment of Cholera Associated with Diminished Susceptibility to Ciprofloxacin to Vibrio cholerae O1.
Khan WA, Saha D, Ahmed S, Salam MA, Bennish ML
PLoS One 2015;10(8):e0134921. Epub 2015 Aug 13 doi: 10.1371/journal.pone.0134921. PMID: 26271050Free PMC Article
Treatment of enteric fever.
Arjyal A, Pandit A
J Infect Dev Ctries 2008 Dec 1;2(6):426-30. doi: 10.3855/jidc.156. PMID: 19745518
The treatment of multidrug-resistant and nalidixic acid-resistant typhoid fever in Viet Nam.
Parry CM
Trans R Soc Trop Med Hyg 2004 Jul;98(7):413-22. doi: 10.1016/j.trstmh.2003.10.014. PMID: 15138078

Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

DailyMed Drug Label, nalidixic acid, 2013

Recent clinical studies

Etiology

Subinhibitory concentrations of nalidixic acid alter bacterial physiology and induce anthropogenic resistance in a commensal strain of Escherichia coli in vitro.
Chadha J, Khullar L
Lett Appl Microbiol 2021 Nov;73(5):623-633. Epub 2021 Aug 24 doi: 10.1111/lam.13550. PMID: 34376018
Efficacy of Ciprofloxacin for Treatment of Cholera Associated with Diminished Susceptibility to Ciprofloxacin to Vibrio cholerae O1.
Khan WA, Saha D, Ahmed S, Salam MA, Bennish ML
PLoS One 2015;10(8):e0134921. Epub 2015 Aug 13 doi: 10.1371/journal.pone.0134921. PMID: 26271050Free PMC Article
Reduction of contamination of mycobacterial growth indicator tubes using increased PANTA concentration.
Peres RL, Palaci M, Loureiro RB, Dietze R, Johnson JL, Maciel EL
Int J Tuberc Lung Dis 2011 Feb;15(2):281-3, i. PMID: 21219695
Campylobacter spp. and their antimicrobial resistance patterns in poultry: an epidemiological survey study in Turkey.
Cokal Y, Caner V, Sen A, Cetin C, Karagenc N
Zoonoses Public Health 2009 Apr;56(3):105-10. Epub 2008 Sep 22 doi: 10.1111/j.1863-2378.2008.01155.x. PMID: 18811676
Photosensitivity associated with antibacterial agents.
Wainwright NJ, Collins P, Ferguson J
Drug Saf 1993 Dec;9(6):437-40. doi: 10.2165/00002018-199309060-00006. PMID: 8129863

Diagnosis

Subinhibitory concentrations of nalidixic acid alter bacterial physiology and induce anthropogenic resistance in a commensal strain of Escherichia coli in vitro.
Chadha J, Khullar L
Lett Appl Microbiol 2021 Nov;73(5):623-633. Epub 2021 Aug 24 doi: 10.1111/lam.13550. PMID: 34376018
Reduction of contamination of mycobacterial growth indicator tubes using increased PANTA concentration.
Peres RL, Palaci M, Loureiro RB, Dietze R, Johnson JL, Maciel EL
Int J Tuberc Lung Dis 2011 Feb;15(2):281-3, i. PMID: 21219695
Treatment of enteric fever.
Arjyal A, Pandit A
J Infect Dev Ctries 2008 Dec 1;2(6):426-30. doi: 10.3855/jidc.156. PMID: 19745518
Photosensitivity due to drugs.
Epstein JH, Wintroub BU
Drugs 1985 Jul;30(1):42-57. doi: 10.2165/00003495-198530010-00005. PMID: 3896743
Nitrofurantoin.
D'Arcy PF
Drug Intell Clin Pharm 1985 Jul-Aug;19(7-8):540-7. doi: 10.1177/106002808501900706. PMID: 3896715

Therapy

Molecular identification and differential proteomics of drug resistant Salmonella Typhi.
Safi AUR, Bendixen E, Rahman H, Khattak B, Wu W, Ullah W, Khan N, Ali F, Yasin N, Qasim M
Diagn Microbiol Infect Dis 2023 Apr;105(4):115883. Epub 2022 Dec 21 doi: 10.1016/j.diagmicrobio.2022.115883. PMID: 36731197
Treatment of enteric fever.
Arjyal A, Pandit A
J Infect Dev Ctries 2008 Dec 1;2(6):426-30. doi: 10.3855/jidc.156. PMID: 19745518
Photosensitivity associated with antibacterial agents.
Wainwright NJ, Collins P, Ferguson J
Drug Saf 1993 Dec;9(6):437-40. doi: 10.2165/00002018-199309060-00006. PMID: 8129863
Photosensitivity due to drugs.
Epstein JH, Wintroub BU
Drugs 1985 Jul;30(1):42-57. doi: 10.2165/00003495-198530010-00005. PMID: 3896743
Nitrofurantoin.
D'Arcy PF
Drug Intell Clin Pharm 1985 Jul-Aug;19(7-8):540-7. doi: 10.1177/106002808501900706. PMID: 3896715

Prognosis

Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
Kamali F, Jamee M, Sayer JA, Sadeghi-Bojd S, Golchehre Z, Dehghanzad R, Keramatipour M, Mohkam M
CEN Case Rep 2023 Nov;12(4):413-418. Epub 2023 Mar 26 doi: 10.1007/s13730-023-00785-8. PMID: 36967423Free PMC Article
The treatment of multidrug-resistant and nalidixic acid-resistant typhoid fever in Viet Nam.
Parry CM
Trans R Soc Trop Med Hyg 2004 Jul;98(7):413-22. doi: 10.1016/j.trstmh.2003.10.014. PMID: 15138078
Response to antimicrobial therapy for shigellosis in Thailand.
Lolekha S, Vibulbandhitkit S, Poonyarit P
Rev Infect Dis 1991 Mar-Apr;13 Suppl 4:S342-6. doi: 10.1093/clinids/13.supplement_4.s342. PMID: 2047660
Nitrofurantoin.
D'Arcy PF
Drug Intell Clin Pharm 1985 Jul-Aug;19(7-8):540-7. doi: 10.1177/106002808501900706. PMID: 3896715
Comparative efficacy of nalidixic acid and ampicillin for severe shigellosis.
Haltalin KC, Nelson JD, Kusmiesz HT
Arch Dis Child 1973 Apr;48(4):305-12. doi: 10.1136/adc.48.4.305. PMID: 4574641Free PMC Article

Clinical prediction guides

Molecular identification and differential proteomics of drug resistant Salmonella Typhi.
Safi AUR, Bendixen E, Rahman H, Khattak B, Wu W, Ullah W, Khan N, Ali F, Yasin N, Qasim M
Diagn Microbiol Infect Dis 2023 Apr;105(4):115883. Epub 2022 Dec 21 doi: 10.1016/j.diagmicrobio.2022.115883. PMID: 36731197
Subinhibitory concentrations of nalidixic acid alter bacterial physiology and induce anthropogenic resistance in a commensal strain of Escherichia coli in vitro.
Chadha J, Khullar L
Lett Appl Microbiol 2021 Nov;73(5):623-633. Epub 2021 Aug 24 doi: 10.1111/lam.13550. PMID: 34376018
Evaluation of antimicrobial resistance profiles of Salmonella isolates from broiler chickens at slaughter in Alberta, Canada.
Mainali C, McFall M, King R, Irwin R
J Food Prot 2014 Mar;77(3):485-92. doi: 10.4315/0362-028X.JFP-13-363. PMID: 24674442
Quinolone resistance and Campylobacter spp.
Piddock LJ
J Antimicrob Chemother 1995 Dec;36(6):891-8. doi: 10.1093/jac/36.6.891. PMID: 8821589
Response to antimicrobial therapy for shigellosis in Thailand.
Lolekha S, Vibulbandhitkit S, Poonyarit P
Rev Infect Dis 1991 Mar-Apr;13 Suppl 4:S342-6. doi: 10.1093/clinids/13.supplement_4.s342. PMID: 2047660

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • CPIC, 2022
      Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.
    • DailyMed Drug Label, 2013
      DailyMed Drug Label, nalidixic acid, 2013

    Consumer resources

    Reviews

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    • PubMed
      Related literature resources in PubMed

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