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Prostaglandin e2 response

MedGen UID:
981350
•Concept ID:
CN298793
•
Sign or Symptom
Drug:
prostaglandin E2
MedGen UID:
3843
•Concept ID:
C0012472
•
Pharmacologic Substance
A synthetic prostaglandin E2 (PGE2) analogue with smooth muscle contraction inducing property. It has been suggested that PGE2 regulates the intracellular levels of cyclic 3, 5-adenosine monophosphate (cAMP) by activating adenylate cyclase and thereby increases cellular membrane calcium ion transport. By acting directly on the myometrium, dinoprostone induces uterine and gastrointestinal smooth muscle contractions. [from NCI]
prostaglandin E2

Professional guidelines

PubMed

Primary hypertrophic osteoarthropathy: genetics, clinical features and management.
Lu Q, Xu Y, Zhang Z, Li S, Zhang Z
Front Endocrinol (Lausanne) 2023;14:1235040. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1235040. PMID: 37705574Free PMC Article
Enthesitis: from pathophysiology to treatment.
Schett G, Lories RJ, D'Agostino MA, Elewaut D, Kirkham B, Soriano ER, McGonagle D
Nat Rev Rheumatol 2017 Nov 21;13(12):731-741. doi: 10.1038/nrrheum.2017.188. PMID: 29158573
Molecular mechanisms of depression: perspectives on new treatment strategies.
Lang UE, Borgwardt S
Cell Physiol Biochem 2013;31(6):761-77. Epub 2013 May 31 doi: 10.1159/000350094. PMID: 23735822

Curated

DailyMed Drug Label, prostaglandin E2, 2019

Recent clinical studies

Etiology

Periodontal disease at the biofilm-gingival interface.
Offenbacher S, Barros SP, Singer RE, Moss K, Williams RC, Beck JD
J Periodontol 2007 Oct;78(10):1911-25. doi: 10.1902/jop.2007.060465. PMID: 18062113

Clinical prediction guides

Periodontal disease at the biofilm-gingival interface.
Offenbacher S, Barros SP, Singer RE, Moss K, Williams RC, Beck JD
J Periodontol 2007 Oct;78(10):1911-25. doi: 10.1902/jop.2007.060465. PMID: 18062113
Serum antibodies to Porphyromonas gingivalis block the prostaglandin E2 response to lipopolysaccharide by mononuclear cells.
Bainbridge BW, Page RC, Darveau RP
Infect Immun 1997 Nov;65(11):4801-5. doi: 10.1128/iai.65.11.4801-4805.1997. PMID: 9353068Free PMC Article
Interleukin-1 beta, tumor necrosis factor, and prostaglandin E2 response after incubation of peritoneal cells and peripheral blood mononuclear cells with lipopolysaccharide.
Friedlander MA
Adv Perit Dial 1991;7:142-9. PMID: 1680412

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