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Aminolevulinic acid response

MedGen UID:
979719
•Concept ID:
CN297614
•
Sign or Symptom
Drug:
aminolevulinic acid
MedGen UID:
1472
•Concept ID:
C0002563
•
Biologically Active Substance
A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. (NCI04) [from NCI]
aminolevulinic acid

Professional guidelines

PubMed

An Efficient 5-Aminolevulinic Acid Photodynamic Therapy Treatment for Human Hepatocellular Carcinoma.
Kumar A, Pecquenard F, Baydoun M, Quilbé A, Moralès O, Leroux B, Aoudjehane L, Conti F, Boleslawski E, Delhem N
Int J Mol Sci 2023 Jun 21;24(13) doi: 10.3390/ijms241310426. PMID: 37445603Free PMC Article
Photodynamic therapy in the treatment of rosacea: A systematic review.
Li A, Fang R, Mao X, Sun Q
Photodiagnosis Photodyn Ther 2022 Jun;38:102875. Epub 2022 Apr 22 doi: 10.1016/j.pdpdt.2022.102875. PMID: 35470124
Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures.
Khan NH, Mir M, Qian L, Baloch M, Ali Khan MF, Rehman AU, Ngowi EE, Wu DD, Ji XY
J Adv Res 2022 Feb;36:223-247. Epub 2021 Jun 16 doi: 10.1016/j.jare.2021.06.014. PMID: 35127174Free PMC Article

Curated

DailyMed Drug Label, aminolevulinic acid, 2020

DailyMed Drug Label, aminolevulinic acid, 2006

Recent clinical studies

Etiology

Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study.
Zhang L, Yang Y, Wang B, Zhao Y, Wang P, Liu J, Yang J, Wu Y, Lv T, Wei Z, Liu X, Wang R, Wong H, Ju Q, Shi L, Wang X
J Am Acad Dermatol 2023 Dec;89(6):1141-1148. Epub 2023 Aug 7 doi: 10.1016/j.jaad.2023.07.1023. PMID: 37558093
Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma.
Nam Y, Koo H, Yang Y, Shin S, Zhu Z, Kim D, Cho HJ, Mu Q, Choi SW, Sa JK, Seo YJ, Kim Y, Lee K, Oh JW, Kwon YJ, Park WY, Kong DS, Seol HJ, Lee JI, Park CK, Lee HW, Yoon Y, Wang J
Genome Med 2023 Mar 13;15(1):16. doi: 10.1186/s13073-023-01165-8. PMID: 36915208Free PMC Article
Crosstalk between Metabolic Disorders and Immune Cells.
Saitoh S, Van Wijk K, Nakajima O
Int J Mol Sci 2021 Sep 16;22(18) doi: 10.3390/ijms221810017. PMID: 34576181Free PMC Article
The Role of Photodynamic Therapy in Acne: An Evidence-Based Review.
Boen M, Brownell J, Patel P, Tsoukas MM
Am J Clin Dermatol 2017 Jun;18(3):311-321. doi: 10.1007/s40257-017-0255-3. PMID: 28276005
Cell biology of heme.
Ponka P
Am J Med Sci 1999 Oct;318(4):241-56. doi: 10.1097/00000441-199910000-00004. PMID: 10522552

Diagnosis

Targeting ABCG2 transporter to enhance 5-aminolevulinic acid for tumor visualization and photodynamic therapy.
Chandratre S, Olsen J, Howley R, Chen B
Biochem Pharmacol 2023 Nov;217:115851. Epub 2023 Oct 17 doi: 10.1016/j.bcp.2023.115851. PMID: 37858868Free PMC Article
Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma.
Nam Y, Koo H, Yang Y, Shin S, Zhu Z, Kim D, Cho HJ, Mu Q, Choi SW, Sa JK, Seo YJ, Kim Y, Lee K, Oh JW, Kwon YJ, Park WY, Kong DS, Seol HJ, Lee JI, Park CK, Lee HW, Yoon Y, Wang J
Genome Med 2023 Mar 13;15(1):16. doi: 10.1186/s13073-023-01165-8. PMID: 36915208Free PMC Article
Photodynamic Therapy for Bladder Cancers, A Focused Review(†).
Rahman KMM, Giram P, Foster BA, You Y
Photochem Photobiol 2023 Mar;99(2):420-436. Epub 2022 Oct 14 doi: 10.1111/php.13726. PMID: 36138552Free PMC Article
5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction.
Fujino M, Nishio Y, Ito H, Tanaka T, Li XK
Int Immunopharmacol 2016 Aug;37:71-78. Epub 2015 Nov 28 doi: 10.1016/j.intimp.2015.11.034. PMID: 26643355
Photodynamic therapy in dermatology.
Fritsch C, Goerz G, Ruzicka T
Arch Dermatol 1998 Feb;134(2):207-14. doi: 10.1001/archderm.134.2.207. PMID: 9487213

Therapy

Beyond fluorescence-guided resection: 5-ALA-based glioblastoma therapies.
Stummer W, Müther M, Spille D
Acta Neurochir (Wien) 2024 Apr 2;166(1):163. doi: 10.1007/s00701-024-06049-3. PMID: 38563988Free PMC Article
Targeting ABCG2 transporter to enhance 5-aminolevulinic acid for tumor visualization and photodynamic therapy.
Chandratre S, Olsen J, Howley R, Chen B
Biochem Pharmacol 2023 Nov;217:115851. Epub 2023 Oct 17 doi: 10.1016/j.bcp.2023.115851. PMID: 37858868Free PMC Article
Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study.
Zhang L, Yang Y, Wang B, Zhao Y, Wang P, Liu J, Yang J, Wu Y, Lv T, Wei Z, Liu X, Wang R, Wong H, Ju Q, Shi L, Wang X
J Am Acad Dermatol 2023 Dec;89(6):1141-1148. Epub 2023 Aug 7 doi: 10.1016/j.jaad.2023.07.1023. PMID: 37558093
Daylight-PDT: everything under the sun.
Beiki D, Eggleston IM, Pourzand C
Biochem Soc Trans 2022 Apr 29;50(2):975-985. doi: 10.1042/BST20200822. PMID: 35385082Free PMC Article
Topical methyl aminolevulinate.
Siddiqui MA, Perry CM, Scott LJ
Am J Clin Dermatol 2004;5(2):127-37; discussion 138-40. doi: 10.2165/00128071-200405020-00006. PMID: 15109276

Prognosis

Beyond fluorescence-guided resection: 5-ALA-based glioblastoma therapies.
Stummer W, Müther M, Spille D
Acta Neurochir (Wien) 2024 Apr 2;166(1):163. doi: 10.1007/s00701-024-06049-3. PMID: 38563988Free PMC Article
Review of the European Society for Photodynamic Therapy (Euro-PDT) Annual Congress 2022.
Morton CA, Szeimies RM, Braathen LR
Eur J Dermatol 2023 Oct 1;33(5):467-473. doi: 10.1684/ejd.2023.4562. PMID: 38297922
Pro-Tumor Activity of Endogenous Nitric Oxide in Anti-Tumor Photodynamic Therapy: Recently Recognized Bystander Effects.
Girotti AW, Bazak J, Korytowski W
Int J Mol Sci 2023 Jul 17;24(14) doi: 10.3390/ijms241411559. PMID: 37511317Free PMC Article
Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma.
Nam Y, Koo H, Yang Y, Shin S, Zhu Z, Kim D, Cho HJ, Mu Q, Choi SW, Sa JK, Seo YJ, Kim Y, Lee K, Oh JW, Kwon YJ, Park WY, Kong DS, Seol HJ, Lee JI, Park CK, Lee HW, Yoon Y, Wang J
Genome Med 2023 Mar 13;15(1):16. doi: 10.1186/s13073-023-01165-8. PMID: 36915208Free PMC Article
5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin.
Lahiji AP, Anderson KE, Chan A, Simon A, Desnick RJ, Ramanujam VMS
Mol Genet Metab 2020 Dec;131(4):418-423. Epub 2020 Oct 26 doi: 10.1016/j.ymgme.2020.10.011. PMID: 33199206

Clinical prediction guides

Heme oxygenase-1 protects cells from replication stress.
Chudy P, Kochan J, Wawro M, Nguyen P, Gorczyca M, Varanko A, Retka A, Ghadei SS, Napieralska E, Grochot-Przęczek A, Szade K, Berendes LS, Park J, Sokołowski G, Yu Q, Józkowicz A, Nowak WN, Krzeptowski W
Redox Biol 2024 Sep;75:103247. Epub 2024 Jun 19 doi: 10.1016/j.redox.2024.103247. PMID: 39047636Free PMC Article
Review of the European Society for Photodynamic Therapy (Euro-PDT) Annual Congress 2022.
Morton CA, Szeimies RM, Braathen LR
Eur J Dermatol 2023 Oct 1;33(5):467-473. doi: 10.1684/ejd.2023.4562. PMID: 38297922
Pro-Tumor Activity of Endogenous Nitric Oxide in Anti-Tumor Photodynamic Therapy: Recently Recognized Bystander Effects.
Girotti AW, Bazak J, Korytowski W
Int J Mol Sci 2023 Jul 17;24(14) doi: 10.3390/ijms241411559. PMID: 37511317Free PMC Article
Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma.
Nam Y, Koo H, Yang Y, Shin S, Zhu Z, Kim D, Cho HJ, Mu Q, Choi SW, Sa JK, Seo YJ, Kim Y, Lee K, Oh JW, Kwon YJ, Park WY, Kong DS, Seol HJ, Lee JI, Park CK, Lee HW, Yoon Y, Wang J
Genome Med 2023 Mar 13;15(1):16. doi: 10.1186/s13073-023-01165-8. PMID: 36915208Free PMC Article
Clinical and Dermoscopic Assessment of Vulvar Lichen Sclerosus After 5-Aminolevulinic Acid Photodynamic Therapy：A Prospective Study.
Liu J, Hao J, Wang Y, Liu Y, Xu T
Photodiagnosis Photodyn Ther 2021 Mar;33:102109. Epub 2020 Nov 24 doi: 10.1016/j.pdpdt.2020.102109. PMID: 33246149

Recent systematic reviews

Photodynamic therapy in the treatment of rosacea: A systematic review.
Li A, Fang R, Mao X, Sun Q
Photodiagnosis Photodyn Ther 2022 Jun;38:102875. Epub 2022 Apr 22 doi: 10.1016/j.pdpdt.2022.102875. PMID: 35470124
5-Aminolevulinic acid radiodynamic therapy for treatment of high-grade gliomas: A systematic review.
Nordmann NJ, Michael AP
Clin Neurol Neurosurg 2021 Feb;201:106430. Epub 2020 Dec 14 doi: 10.1016/j.clineuro.2020.106430. PMID: 33360951
Photodynamic therapy for extramammary Paget's disease: A systematic review of the literature.
Shim PJ, Zeitouni NC
Photodiagnosis Photodyn Ther 2020 Sep;31:101911. Epub 2020 Jul 6 doi: 10.1016/j.pdpdt.2020.101911. PMID: 32645437
The Role of Photodynamic Therapy in Acne: An Evidence-Based Review.
Boen M, Brownell J, Patel P, Tsoukas MM
Am J Clin Dermatol 2017 Jun;18(3):311-321. doi: 10.1007/s40257-017-0255-3. PMID: 28276005
Photodynamic therapy for actinic cheilitis: a systematic review.
Yazdani Abyaneh MA, Falto-Aizpurua L, Griffith RD, Nouri K
Dermatol Surg 2015 Feb;41(2):189-98. doi: 10.1097/DSS.0000000000000254. PMID: 25627629

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