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Akathisia

MedGen UID:
97881
Concept ID:
C0392156
Sign or Symptom
SNOMED CT: Akathisia (285145004)
 
HPO: HP:0031943

Definition

A state of motor restlessness, usually in the lower extremities, that is often but not always accompanied by a subjective sense of inner restlessness, an urge to move, and anxiety or dysphoria. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAkathisia

Conditions with this feature

Tardive dyskinesia
MedGen UID:
151939
Concept ID:
C0686347
Disease or Syndrome
Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008).

Professional guidelines

PubMed

Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Vas C, Jain A, Trivedi M, Jha MK, Mathew SJ
Psychiatr Clin North Am 2023 Jun;46(2):261-275. Epub 2023 Mar 25 doi: 10.1016/j.psc.2023.02.012. PMID: 37149344
Preda A, Shapiro BB
Expert Opin Drug Saf 2020 Dec;19(12):1529-1538. Epub 2020 Oct 16 doi: 10.1080/14740338.2020.1832990. PMID: 33064050

Recent clinical studies

Etiology

Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Wu H, Siafis S, Wang D, Burschinski A, Schneider-Thoma J, Priller J, Davis JM, Leucht S
Eur Neuropsychopharmacol 2023 Jul;72:40-49. Epub 2023 Apr 17 doi: 10.1016/j.euroneuro.2023.03.015. PMID: 37075639
Sienaert P, van Harten P, Rhebergen D
Handb Clin Neurol 2019;165:415-428. doi: 10.1016/B978-0-444-64012-3.00025-3. PMID: 31727227
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749
Jiménez-Jiménez FJ, García-Ruiz PJ, Molina JA
Drug Saf 1997 Mar;16(3):180-204. doi: 10.2165/00002018-199716030-00004. PMID: 9098656

Diagnosis

Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Nilles C, Amorelli G, Pringsheim TM, Martino D
Semin Neurol 2023 Feb;43(1):123-146. Epub 2023 Feb 28 doi: 10.1055/s-0043-1764164. PMID: 36854394
Ali T, Sisay M, Tariku M, Mekuria AN, Desalew A
PLoS One 2021;16(9):e0257129. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257129. PMID: 34506552Free PMC Article
Stefani A, Högl B
Neuropsychopharmacology 2020 Jan;45(1):121-128. Epub 2019 Jun 24 doi: 10.1038/s41386-019-0448-y. PMID: 31234200Free PMC Article
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749

Therapy

Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Wu H, Siafis S, Wang D, Burschinski A, Schneider-Thoma J, Priller J, Davis JM, Leucht S
Eur Neuropsychopharmacol 2023 Jul;72:40-49. Epub 2023 Apr 17 doi: 10.1016/j.euroneuro.2023.03.015. PMID: 37075639
McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J
Cochrane Database Syst Rev 2019 Mar 20;3(3):CD003154. doi: 10.1002/14651858.CD003154.pub6. PMID: 30891742Free PMC Article
Markovic M, Gallipani A, Patel KH, Maroney M
Ann Pharmacother 2017 Apr;51(4):315-322. Epub 2016 Dec 15 doi: 10.1177/1060028016678262. PMID: 28228056
Matar HE, Almerie MQ, Makhoul S, Xia J, Humphreys P
Cochrane Database Syst Rev 2014 May 13;2014(5):CD007479. doi: 10.1002/14651858.CD007479.pub2. PMID: 24825770Free PMC Article

Prognosis

Thippaiah SM, Fargason RE, Birur B
Psychopharmacol Bull 2021 Jun 1;51(3):72-78. PMID: 34421146Free PMC Article
Adams R, Chopra P, Miranda R, Calderon A
BMJ Case Rep 2020 Jun 1;13(6) doi: 10.1136/bcr-2019-231875. PMID: 32487528Free PMC Article
Savitt D, Jankovic J
J Neurol Sci 2018 Jun 15;389:35-42. Epub 2018 Feb 5 doi: 10.1016/j.jns.2018.02.005. PMID: 29506749
Mohamed S, Johnson GR, Chen P, Hicks PB, Davis LL, Yoon J, Gleason TC, Vertrees JE, Weingart K, Tal I, Scrymgeour A, Lawrence DD, Planeta B, Thase ME, Huang GD, Zisook S; and the VAST-D Investigators, Rao SD, Pilkinton PD, Wilcox JA, Iranmanesh A, Sapra M, Jurjus G, Michalets JP, Aslam M, Beresford T, Anderson KD, Fernando R, Ramaswamy S, Kasckow J, Westermeyer J, Yoon G, D'Souza DC, Larson G, Anderson WG, Klatt M, Fareed A, Thompson SI, Carrera CJ, Williams SS, Juergens TM, Albers LJ, Nasdahl CS, Villarreal G, Winston JL, Nogues CA, Connolly KR, Tapp A, Jones KA, Khatkhate G, Marri S, Suppes T, LaMotte J, Hurley R, Mayeda AR, Niculescu AB 3rd, Fischer BA, Loreck DJ, Rosenlicht N, Lieske S, Finkel MS, Little JT
JAMA 2017 Jul 11;318(2):132-145. doi: 10.1001/jama.2017.8036. PMID: 28697253Free PMC Article
Casey DE
West J Med 1990 Nov;153(5):535-41. PMID: 1979705Free PMC Article

Clinical prediction guides

Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Frank S, Testa C, Edmondson MC, Goldstein J, Kayson E, Leavitt BR, Oakes D, O'Neill C, Vaughan C, Whaley J, Gross N, Gordon MF, Savola JM; Huntington Study Group/ARC-HD Investigators and Coordinators
CNS Drugs 2022 Nov;36(11):1207-1216. Epub 2022 Oct 15 doi: 10.1007/s40263-022-00956-8. PMID: 36242718Free PMC Article
Ali T, Sisay M, Tariku M, Mekuria AN, Desalew A
PLoS One 2021;16(9):e0257129. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257129. PMID: 34506552Free PMC Article
Adams R, Chopra P, Miranda R, Calderon A
BMJ Case Rep 2020 Jun 1;13(6) doi: 10.1136/bcr-2019-231875. PMID: 32487528Free PMC Article
Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE, Reynolds CF 3rd
Lancet 2015 Dec 12;386(10011):2404-12. Epub 2015 Sep 27 doi: 10.1016/S0140-6736(15)00308-6. PMID: 26423182Free PMC Article

Recent systematic reviews

Gerolymos C, Barazer R, Yon DK, Loundou A, Boyer L, Fond G
JAMA Netw Open 2024 Mar 4;7(3):e241527. doi: 10.1001/jamanetworkopen.2024.1527. PMID: 38451521Free PMC Article
Wu H, Siafis S, Wang D, Burschinski A, Schneider-Thoma J, Priller J, Davis JM, Leucht S
Eur Neuropsychopharmacol 2023 Jul;72:40-49. Epub 2023 Apr 17 doi: 10.1016/j.euroneuro.2023.03.015. PMID: 37075639
Ali T, Sisay M, Tariku M, Mekuria AN, Desalew A
PLoS One 2021;16(9):e0257129. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257129. PMID: 34506552Free PMC Article
McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J
Cochrane Database Syst Rev 2019 Mar 20;3(3):CD003154. doi: 10.1002/14651858.CD003154.pub6. PMID: 30891742Free PMC Article
Zhang JP, Gallego JA, Robinson DG, Malhotra AK, Kane JM, Correll CU
Int J Neuropsychopharmacol 2013 Jul;16(6):1205-18. Epub 2012 Dec 3 doi: 10.1017/S1461145712001277. PMID: 23199972Free PMC Article

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