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Deep cerebral white matter hyperintensities

MedGen UID:
927594
•Concept ID:
C4293685
•
Finding
Synonym: Deep cerebral white matter hyperdensities
 
HPO: HP:0030892

Definition

Areas of brighter than expected signal on magnetic resonance imaging emanating from locations distant from the ventricular system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeep cerebral white matter hyperintensities

Professional guidelines

PubMed

Primary central nervous system lymphoma: Imaging features and differential diagnosis.
Ribas GA, de Mori LH, Freddi TAL, Oliveira LDS, de Souza SR, Corrêa DG
Neuroradiol J 2024 Dec;37(6):705-722. Epub 2024 May 4 doi: 10.1177/19714009241252625. PMID: 38703015Free PMC Article
Diagnosis and Treatment Effect of Convolutional Neural Network-Based Magnetic Resonance Image Features on Severe Stroke and Mental State.
Han L, Liu L, Hao Y, Zhang L
Contrast Media Mol Imaging 2021;2021:8947789. Epub 2021 Jul 26 doi: 10.1155/2021/8947789. PMID: 34385898Free PMC Article
Genotype-phenotype correlations of cysteine replacement in CADASIL.
Matsushima T, Conedera S, Tanaka R, Li Y, Yoshino H, Funayama M, Ikeda A, Hosaka Y, Okuzumi A, Shimada Y, Yamashiro K, Motoi Y, Nishioka K, Hattori N
Neurobiol Aging 2017 Feb;50:169.e7-169.e14. Epub 2016 Nov 2 doi: 10.1016/j.neurobiolaging.2016.10.026. PMID: 27890607

Recent clinical studies

Etiology

Nonhypertensive White Matter Hyperintensities in Stroke: Risk Factors, Neuroimaging Characteristics, and Prognosis.
Lim JS, Lee KJ, Kim BJ, Ryu WS, Chung J, Gwak DS, Lee JS, Kim SE, Ko E, Lee J, Han MK, Smith EE, Kim DE, Bae HJ
J Am Heart Assoc 2023 Dec 5;12(23):e030515. Epub 2023 Nov 28 doi: 10.1161/JAHA.123.030515. PMID: 38014679Free PMC Article
Neuroticism and white matter hyperintensities.
Terracciano A, Cenatus B, Zhu X, Karakose S, Stephan Y, Marcolini S, De Deyn PP, Luchetti M, Sutin AR
J Psychiatr Res 2023 Sep;165:174-179. Epub 2023 Jul 21 doi: 10.1016/j.jpsychires.2023.07.026. PMID: 37506413Free PMC Article
Cerebral small vessel disease: A review.
Chojdak-Łukasiewicz J, Dziadkowiak E, Zimny A, Paradowski B
Adv Clin Exp Med 2021 Mar;30(3):349-356. doi: 10.17219/acem/131216. PMID: 33768739
White Matter Lesions in Migraine.
Eikermann-Haerter K, Huang SY
Am J Pathol 2021 Nov;191(11):1955-1962. Epub 2021 Feb 24 doi: 10.1016/j.ajpath.2021.02.007. PMID: 33636178
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Diagnosis

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
HTLV-1 encephalitis.
King-Robson J, Hampton T, Rosadas C, Taylor GP, Stanton B
Pract Neurol 2022 Feb;22(1):60-63. Epub 2021 Aug 30 doi: 10.1136/practneurol-2021-003053. PMID: 34462338
Cerebral small vessel disease: A review.
Chojdak-Łukasiewicz J, Dziadkowiak E, Zimny A, Paradowski B
Adv Clin Exp Med 2021 Mar;30(3):349-356. doi: 10.17219/acem/131216. PMID: 33768739
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Therapy

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Cerebral white matter burden is linked to cognitive function in patients undergoing hemodialysis.
Wu TS, Wu PH, Lin HF, Chen WC, Huang TH, Lin MY, Chuang YS, Yang FG, Chiu YW, Chang JM, Kuo MC, Lin YT
Ann Med 2024 Dec;56(1):2310142. Epub 2024 Feb 7 doi: 10.1080/07853890.2024.2310142. PMID: 38324920Free PMC Article
Implication of heart rate variability on cerebral small vessel disease: A potential therapeutic target.
Tian Y, Yao D, Pan Y, Wang M, Meng X, Zhao X, Liu L, Wang Y, Wang Y
CNS Neurosci Ther 2023 May;29(5):1379-1391. Epub 2023 Feb 14 doi: 10.1111/cns.14111. PMID: 36786131Free PMC Article
Associations between white matter hyperintensities, striatal dopamine loss, and cognition in drug-naïve Parkinson's disease.
Jeong SH, Lee HS, Jung JH, Baik K, Sohn YH, Chung SJ, Lee PH
Parkinsonism Relat Disord 2022 Apr;97:1-7. Epub 2022 Mar 3 doi: 10.1016/j.parkreldis.2022.02.020. PMID: 35276583
White matter hyperintensities in patients with Parkinson's disease: A systematic review and meta-analysis.
Butt A, Kamtchum-Tatuene J, Khan K, Shuaib A, Jickling GC, Miyasaki JM, Smith EE, Camicioli R
J Neurol Sci 2021 Jul 15;426:117481. Epub 2021 May 4 doi: 10.1016/j.jns.2021.117481. PMID: 33975191

Prognosis

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Nonhypertensive White Matter Hyperintensities in Stroke: Risk Factors, Neuroimaging Characteristics, and Prognosis.
Lim JS, Lee KJ, Kim BJ, Ryu WS, Chung J, Gwak DS, Lee JS, Kim SE, Ko E, Lee J, Han MK, Smith EE, Kim DE, Bae HJ
J Am Heart Assoc 2023 Dec 5;12(23):e030515. Epub 2023 Nov 28 doi: 10.1161/JAHA.123.030515. PMID: 38014679Free PMC Article
Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study.
Sleight E, Stringer MS, Clancy U, Arteaga C, Jaime Garcia D, Hewins W, Jochems ACC, Hamilton OKL, Manning C, Morgan AG, Locherty R, Cheng Y, Liu X, Zhang J, Hamilton I, Jardine C, Brown R, Sakka E, Kampaite A, Wiseman S, Valdés-Hernández MC, Chappell FM, Doubal FN, Marshall I, Thrippleton MJ, Wardlaw JM
Stroke 2023 Nov;54(11):2776-2784. Epub 2023 Oct 10 doi: 10.1161/STROKEAHA.123.042656. PMID: 37814956Free PMC Article
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Diabetes mellitus and white matter hyperintensity.
Tamura Y, Araki A
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:34-42. doi: 10.1111/ggi.12666. PMID: 26671155

Clinical prediction guides

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Nonhypertensive White Matter Hyperintensities in Stroke: Risk Factors, Neuroimaging Characteristics, and Prognosis.
Lim JS, Lee KJ, Kim BJ, Ryu WS, Chung J, Gwak DS, Lee JS, Kim SE, Ko E, Lee J, Han MK, Smith EE, Kim DE, Bae HJ
J Am Heart Assoc 2023 Dec 5;12(23):e030515. Epub 2023 Nov 28 doi: 10.1161/JAHA.123.030515. PMID: 38014679Free PMC Article
Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study.
Sleight E, Stringer MS, Clancy U, Arteaga C, Jaime Garcia D, Hewins W, Jochems ACC, Hamilton OKL, Manning C, Morgan AG, Locherty R, Cheng Y, Liu X, Zhang J, Hamilton I, Jardine C, Brown R, Sakka E, Kampaite A, Wiseman S, Valdés-Hernández MC, Chappell FM, Doubal FN, Marshall I, Thrippleton MJ, Wardlaw JM
Stroke 2023 Nov;54(11):2776-2784. Epub 2023 Oct 10 doi: 10.1161/STROKEAHA.123.042656. PMID: 37814956Free PMC Article
Menopausal Vasomotor Symptoms and White Matter Hyperintensities in Midlife Women.
Thurston RC, Wu M, Chang YF, Aizenstein HJ, Derby CA, Barinas-Mitchell EA, Maki P
Neurology 2023 Jan 10;100(2):e133-e141. Epub 2022 Oct 12 doi: 10.1212/WNL.0000000000201401. PMID: 36224031Free PMC Article
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA
AJR Am J Roentgenol 1987 Aug;149(2):351-6. doi: 10.2214/ajr.149.2.351. PMID: 3496763

Recent systematic reviews

White matter hyperintensities and post-stroke depression: A systematic review and meta-analysis.
Zhang F, Ping Y, Jin X, Hou X, Song J
J Affect Disord 2023 Jan 1;320:370-380. Epub 2022 Oct 6 doi: 10.1016/j.jad.2022.09.166. PMID: 36209775
White matter hyperintensities in patients with Parkinson's disease: A systematic review and meta-analysis.
Butt A, Kamtchum-Tatuene J, Khan K, Shuaib A, Jickling GC, Miyasaki JM, Smith EE, Camicioli R
J Neurol Sci 2021 Jul 15;426:117481. Epub 2021 May 4 doi: 10.1016/j.jns.2021.117481. PMID: 33975191
White matter lesions and depression: a systematic review and meta-analysis.
Wang L, Leonards CO, Sterzer P, Ebinger M
J Psychiatr Res 2014 Sep;56:56-64. Epub 2014 Jun 9 doi: 10.1016/j.jpsychires.2014.05.005. PMID: 24948437
Systematic review of structural and functional neuroimaging findings in children and adults with CKD.
Moodalbail DG, Reiser KA, Detre JA, Schultz RT, Herrington JD, Davatzikos C, Doshi JJ, Erus G, Liu HS, Radcliffe J, Furth SL, Hooper SR
Clin J Am Soc Nephrol 2013 Aug;8(8):1429-48. Epub 2013 May 30 doi: 10.2215/CJN.11601112. PMID: 23723341Free PMC Article
White matter hyperintensities in late life depression: a systematic review.
Herrmann LL, Le Masurier M, Ebmeier KP
J Neurol Neurosurg Psychiatry 2008 Jun;79(6):619-24. Epub 2007 Aug 23 doi: 10.1136/jnnp.2007.124651. PMID: 17717021

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