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Fallopian Tube High Grade Serous Adenocarcinoma

MedGen UID:
926492
•Concept ID:
C4288960
•
Neoplastic Process
Synonyms: Fallopian Tube High-Grade Serous Adenocarcinoma; High Grade Fallopian Tube Serous Adenocarcinoma; High Grade Fallopian Tube Serous Carcinoma

Definition

A rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures. [from NCI]

Professional guidelines

PubMed

Consensus based recommendations for the diagnosis of serous tubal intraepithelial carcinoma: an international Delphi study.
Bogaerts JMA, van Bommel MHD, Hermens RPMG, Steenbeek MP, de Hullu JA, van der Laak JAWM; STIC consortium, Simons M
Histopathology 2023 Jul;83(1):67-79. Epub 2023 Mar 20 doi: 10.1111/his.14902. PMID: 36939551
Incorporating PARP-inhibitors into clinical routine: A tailored treatment strategy to tackle ovarian cancer.
De Jaeghere E, Vandecasteele K, Claes K, Makar A, Tummers P, Cocquyt V, Denys H
Acta Clin Belg 2017 Feb;72(1):6-11. Epub 2016 May 31 doi: 10.1080/17843286.2016.1188455. PMID: 27267353
Primary site assignment in tubo-ovarian high-grade serous carcinoma: Consensus statement on unifying practice worldwide.
Singh N, Gilks CB, Hirschowitz L, Kehoe S, McNeish IA, Miller D, Naik R, Wilkinson N, McCluggage WG
Gynecol Oncol 2016 May;141(2):195-198. Epub 2016 Jan 28 doi: 10.1016/j.ygyno.2015.10.022. PMID: 26827965

Recent clinical studies

Etiology

Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions.
Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM
Am J Surg Pathol 2024 Apr 1;48(4):475-486. Epub 2024 Feb 1 doi: 10.1097/PAS.0000000000002187. PMID: 38298022Free PMC Article
Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma.
Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S
Cancer Cell 2023 Jun 12;41(6):1103-1117.e12. Epub 2023 May 18 doi: 10.1016/j.ccell.2023.04.017. PMID: 37207655
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Whence High-Grade Serous Ovarian Cancer.
Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article

Diagnosis

Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma.
Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S
Cancer Cell 2023 Jun 12;41(6):1103-1117.e12. Epub 2023 May 18 doi: 10.1016/j.ccell.2023.04.017. PMID: 37207655
The Origin of Ovarian Cancer Species and Precancerous Landscape.
Shih IM, Wang Y, Wang TL
Am J Pathol 2021 Jan;191(1):26-39. Epub 2020 Oct 1 doi: 10.1016/j.ajpath.2020.09.006. PMID: 33011111Free PMC Article
The Many Microenvironments of Ovarian Cancer.
Micek HM, Visetsouk MR, Fleszar AJ, Kreeger PK
Adv Exp Med Biol 2020;1296:199-213. doi: 10.1007/978-3-030-59038-3_12. PMID: 34185294Free PMC Article
Fallopian Tube Neoplasia and Mimics.
Kolin DL, Nucci MR
Surg Pathol Clin 2019 Jun;12(2):457-479. doi: 10.1016/j.path.2019.01.006. PMID: 31097111
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Therapy

LRP1B-a prognostic marker in tubo-ovarian high-grade serous carcinoma.
Kolb S, Hoffmann I, Monjé N, Dragomir MP, Jank P, Bischoff P, Keunecke C, Pohl J, Kunze CA, Marchenko S, Schmitt WD, Kulbe H, Sers C, Sehouli J, Braicu EI, Denkert C, Darb-Esfahani S, Horst D, Sinn BV, Taube ET
Hum Pathol 2023 Nov;141:158-168. Epub 2023 Sep 22 doi: 10.1016/j.humpath.2023.09.001. PMID: 37742945
Low grade serous ovarian cancer - A rare disease with increasing therapeutic options.
Zwimpfer TA, Tal O, Geissler F, Coelho R, Rimmer N, Jacob F, Heinzelmann-Schwarz V
Cancer Treat Rev 2023 Jan;112:102497. Epub 2022 Dec 10 doi: 10.1016/j.ctrv.2022.102497. PMID: 36525716
Ovarian High-Grade Serous Carcinoma: Assessing Pathology for Site of Origin, Staging and Post-neoadjuvant Chemotherapy Changes.
Casey L, Singh N
Surg Pathol Clin 2019 Jun;12(2):515-528. doi: 10.1016/j.path.2019.01.007. PMID: 31097113
Pathogenesis and heterogeneity of ovarian cancer.
Kroeger PT Jr, Drapkin R
Curr Opin Obstet Gynecol 2017 Feb;29(1):26-34. doi: 10.1097/GCO.0000000000000340. PMID: 27898521Free PMC Article
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Prognosis

The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions.
MacFawn IP, Magnon G, Gorecki G, Kunning S, Rashid R, Kaiza ME, Atiya H, Ruffin AT, Taylor S, Soong TR, Bao R, Coffman LG, Bruno TC
Cancer Cell 2024 Nov 11;42(11):1864-1881.e5. Epub 2024 Oct 10 doi: 10.1016/j.ccell.2024.09.007. PMID: 39393357
TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer.
Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C, Novak M, McDermott J, Brenton JD, Cutillas PR, Rajeeve V, Hennino A, Drapkin R, Loessner D, Balkwill FR
Cancer Res 2021 Nov 15;81(22):5706-5719. Epub 2021 Sep 24 doi: 10.1158/0008-5472.CAN-21-0536. PMID: 34561272Free PMC Article
The Many Microenvironments of Ovarian Cancer.
Micek HM, Visetsouk MR, Fleszar AJ, Kreeger PK
Adv Exp Med Biol 2020;1296:199-213. doi: 10.1007/978-3-030-59038-3_12. PMID: 34185294Free PMC Article
Whence High-Grade Serous Ovarian Cancer.
Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Clinical prediction guides

Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions.
Chien YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM
Am J Surg Pathol 2024 Apr 1;48(4):475-486. Epub 2024 Feb 1 doi: 10.1097/PAS.0000000000002187. PMID: 38298022Free PMC Article
CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR.
Bapat J, Yamamoto TM, Woodruff ER, Qamar L, Mikeska RG, Aird KM, Watson ZL, Brubaker LW, Bitler BG
Cancer Gene Ther 2024 Feb;31(2):300-310. Epub 2023 Nov 29 doi: 10.1038/s41417-023-00703-1. PMID: 38030811Free PMC Article
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Whence High-Grade Serous Ovarian Cancer.
Kohn EC, Ivy SP
Am Soc Clin Oncol Educ Book 2017;37:443-448. doi: 10.1200/EDBK_174718. PMID: 28561656
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Recent systematic reviews

Outcome and Management of Serous Tubal Intraepithelial Carcinoma Following Opportunistic Salpingectomy: Systematic Review and Meta-Analysis.
Ruel-Laliberté J, Kasasni SM, Oprea D, Viau M
J Obstet Gynaecol Can 2022 Nov;44(11):1174-1180. Epub 2022 Sep 12 doi: 10.1016/j.jogc.2022.08.018. PMID: 36099965
Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA
J Clin Oncol 2022 Jun 10;40(17):1879-1891. Epub 2022 Mar 18 doi: 10.1200/JCO.21.02016. PMID: 35302882Free PMC Article
Recommendations for diagnosing STIC: a systematic review and meta-analysis.
Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article

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