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Oropharyngeal Basaloid Carcinoma

MedGen UID:
926083
•Concept ID:
C4288551
•
Neoplastic Process

Definition

A high-grade variant of squamous cell carcinoma that arises from the oropharynx. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal Basaloid Carcinoma

Professional guidelines

PubMed

Oropharyngeal Squamous Cell Carcinoma in 390 Patients: Analysis of Clinical and Histological Criteria Which Significantly Impact Outcome.
Thompson LDR, Burchette R, Iganej S, Bhattasali O
Head Neck Pathol 2020 Sep;14(3):666-688. Epub 2019 Nov 18 doi: 10.1007/s12105-019-01096-0. PMID: 31741151Free PMC Article
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782
Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA
J Clin Pathol 2010 Oct;63(10):857-66. doi: 10.1136/jcp.2010.078154. PMID: 20876315

Recent clinical studies

Etiology

HPV-Associated Squamous Cell Carcinoma of the Eyelid: Diagnostic Utility of p16 Immunohistochemistry and mRNA In Situ Hybridization.
Kakkar A, Srivastava K, Deepa S, Kashyap S, Sen S, Bhoriwal S, Kaur K, Deo SVS
Head Neck Pathol 2023 Dec;17(4):889-898. Epub 2023 Sep 21 doi: 10.1007/s12105-023-01582-6. PMID: 37735287Free PMC Article
Utility of p16 and HPV testing in oropharyngeal squamous cell carcinoma: An institutional review.
Abdelhakam DA, Huenerberg KA, Nassar A
Diagn Cytopathol 2021 Jan;49(1):54-59. Epub 2020 Aug 26 doi: 10.1002/dc.24593. PMID: 32845095
HPV-related squamous cell carcinoma of oropharynx: a review.
Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Recent data about the role of human papillomavirus (HPV) in oncogenesis of head and neck cancer.
Bădulescu F, Crişan A, Bădulescu A, Schenker M
Rom J Morphol Embryol 2010;51(3):437-40. PMID: 20809017

Diagnosis

HPV-Associated Squamous Cell Carcinoma of the Eyelid: Diagnostic Utility of p16 Immunohistochemistry and mRNA In Situ Hybridization.
Kakkar A, Srivastava K, Deepa S, Kashyap S, Sen S, Bhoriwal S, Kaur K, Deo SVS
Head Neck Pathol 2023 Dec;17(4):889-898. Epub 2023 Sep 21 doi: 10.1007/s12105-023-01582-6. PMID: 37735287Free PMC Article
Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants.
Wenig BM
Mod Pathol 2017 Jan;30(s1):S112-S118. doi: 10.1038/modpathol.2016.207. PMID: 28060368
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

Therapy

New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) expression, and HPV status.
Laco J, Nekvindova J, Novakova V, Celakovsky P, Dolezalova H, Tucek L, Vosmikova H, Vosmik M, Neskudlova T, Cermakova E, Hacova M, Sobande FA, Ryska A
Neoplasma 2012;59(4):398-408. doi: 10.4149/neo_2012_052. PMID: 22489695
Recent data about the role of human papillomavirus (HPV) in oncogenesis of head and neck cancer.
Bădulescu F, Crişan A, Bădulescu A, Schenker M
Rom J Morphol Embryol 2010;51(3):437-40. PMID: 20809017
Role of human papillomavirus in the development of head and neck squamous cell carcinomas.
Hafkamp HC, Manni JJ, Speel EJ
Acta Otolaryngol 2004 May;124(4):520-6. doi: 10.1080/00016480310016893. PMID: 15224887
Different risk factors in basaloid and common squamous head and neck cancer.
Kleist B, Bankau A, Lorenz G, Jäger B, Poetsch M
Laryngoscope 2004 Jun;114(6):1063-8. doi: 10.1097/00005537-200406000-00020. PMID: 15179214

Prognosis

HPV-Associated Squamous Cell Carcinoma of the Eyelid: Diagnostic Utility of p16 Immunohistochemistry and mRNA In Situ Hybridization.
Kakkar A, Srivastava K, Deepa S, Kashyap S, Sen S, Bhoriwal S, Kaur K, Deo SVS
Head Neck Pathol 2023 Dec;17(4):889-898. Epub 2023 Sep 21 doi: 10.1007/s12105-023-01582-6. PMID: 37735287Free PMC Article
Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants.
Wenig BM
Mod Pathol 2017 Jan;30(s1):S112-S118. doi: 10.1038/modpathol.2016.207. PMID: 28060368
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Recent data about the role of human papillomavirus (HPV) in oncogenesis of head and neck cancer.
Bădulescu F, Crişan A, Bădulescu A, Schenker M
Rom J Morphol Embryol 2010;51(3):437-40. PMID: 20809017

Clinical prediction guides

Elective Neck Dissection in cT1-4 N0M0 Head and Neck Basaloid Carcinoma.
Patel AM, Haleem A, Choudhry HS, Brody RM, Brant JA, Carey RM
Otolaryngol Head Neck Surg 2024 Aug;171(2):457-470. Epub 2024 Apr 12 doi: 10.1002/ohn.757. PMID: 38613196
Utility of p16 and HPV testing in oropharyngeal squamous cell carcinoma: An institutional review.
Abdelhakam DA, Huenerberg KA, Nassar A
Diagn Cytopathol 2021 Jan;49(1):54-59. Epub 2020 Aug 26 doi: 10.1002/dc.24593. PMID: 32845095
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

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