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Recurrent Lung Non-Squamous Non-Small Cell Carcinoma

MedGen UID:
925836
•Concept ID:
C4288304
•
Neoplastic Process
Synonyms: Recurrent Non-Squamous Non-Small Cell Lung Cancer; Recurrent Non-Squamous Non-Small Cell Lung Carcinoma

Definition

The reemergence of non-squamous non-small cell lung carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Lung Non-Squamous Non-Small Cell Carcinoma

Professional guidelines

PubMed

The Effect of Gefitinib on Treatment Necessity and Prognosis of NSCLC Patients with Early EGFR Mutations.
Song R, Cheng Y, Zheng T
Contrast Media Mol Imaging 2022;2022:2228744. Epub 2022 Oct 11 doi: 10.1155/2022/2228744. PMID: 36304772Free PMC Article
Recurrence patterns and impact of brain metastases in synchronous single organ oligometastatic lung cancer following local ablative treatment - A multicenter analysis.
Frost N, Roeper J, Velthaus JL, Raspe M, Olive E, Schmittel A, Schmidt B, Wasilewski D, Onken J, Lüders H, Witzenrath M, Senger C, Böhmer D, Loges S, Griesinger F, Modest DP, Grohé C
Lung Cancer 2022 Aug;170:165-175. Epub 2022 Jul 2 doi: 10.1016/j.lungcan.2022.06.017. PMID: 35803041
Pemetrexed in the treatment of advanced non-squamous lung cancer.
Rossi A, Ricciardi S, Maione P, de Marinis F, Gridelli C
Lung Cancer 2009 Nov;66(2):141-9. Epub 2009 Jul 4 doi: 10.1016/j.lungcan.2009.06.006. PMID: 19577816

Recent clinical studies

Etiology

STK11/LKB1 alterations worsen the poor prognosis of KRAS mutated early-stage non-squamous non-small cell lung carcinoma, results based on the phase 2 IFCT TASTE trial.
Oudart JB, Garinet S, Leger C, Barlesi F, Mazières J, Jeannin G, Audigier-Valette C, Morot-Sibilot D, Langlais A, Amour E, Mathiot N, Birsen G, Blons H, Wislez M
Lung Cancer 2024 Apr;190:107508. Epub 2024 Feb 19 doi: 10.1016/j.lungcan.2024.107508. PMID: 38428265
Randomized, open-label phase II study of brigatinib and carboplatin plus pemetrexed and brigatinib alone for chemotherapy-naive patients with ALK-rearranged non-squamous non-small cell lung cancer: treatment rationale and protocol design of the B-DASH study (WJOG 14720 L).
Wakuda K, Kenmotsu H, Sato Y, Nakamura A, Akamatsu H, Tachihara M, Miura S, Yokoyama T, Mori K, Nakagawa K, Yamamoto N
BMC Cancer 2023 Sep 25;23(1):902. doi: 10.1186/s12885-023-11417-w. PMID: 37749521Free PMC Article
Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges.
Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM
Lung Cancer 2021 Dec;162:42-53. Epub 2021 Sep 15 doi: 10.1016/j.lungcan.2021.09.003. PMID: 34739853
Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial.
Saito H, Fukuhara T, Furuya N, Watanabe K, Sugawara S, Iwasawa S, Tsunezuka Y, Yamaguchi O, Okada M, Yoshimori K, Nakachi I, Gemma A, Azuma K, Kurimoto F, Tsubata Y, Fujita Y, Nagashima H, Asai G, Watanabe S, Miyazaki M, Hagiwara K, Nukiwa T, Morita S, Kobayashi K, Maemondo M
Lancet Oncol 2019 May;20(5):625-635. Epub 2019 Apr 8 doi: 10.1016/S1470-2045(19)30035-X. PMID: 30975627
Nivolumab in advanced non-small-cell lung cancer patients who failed prior platinum-based chemotherapy.
Lee JS, Lee KH, Cho EK, Kim DW, Kim SW, Kim JH, Cho BC, Kang JH, Han JY, Min YJ, Park K
Lung Cancer 2018 Aug;122:234-242. Epub 2018 May 24 doi: 10.1016/j.lungcan.2018.05.023. PMID: 30032838

Diagnosis

Predictive value of EGFR mutation in non-small-cell lung cancer patients treated with platinum doublet postoperative chemotherapy.
Takahashi T, Sakai K, Kenmotsu H, Yoh K, Daga H, Ohira T, Ueno T, Aoki T, Hayashi H, Yamazaki K, Hosomi Y, Chen-Yoshikawa TF, Okumura N, Takiguchi Y, Sekine A, Haruki T, Yamamoto H, Sato Y, Akamatsu H, Seto T, Saeki S, Sugio K, Nishio M, Inokawa H, Yamamoto N, Nishio K, Tsuboi M
Cancer Sci 2022 Jan;113(1):287-296. Epub 2021 Nov 7 doi: 10.1111/cas.15171. PMID: 34689382Free PMC Article
Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges.
Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM
Lung Cancer 2021 Dec;162:42-53. Epub 2021 Sep 15 doi: 10.1016/j.lungcan.2021.09.003. PMID: 34739853
Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer.
Cui W, Franchini F, Alexander M, Officer A, Wong HL, IJzerman M, Desai J, Solomon BJ
Lung Cancer 2020 Aug;146:310-317. Epub 2020 Jun 26 doi: 10.1016/j.lungcan.2020.06.030. PMID: 32619782
Final results of the SENECA (SEcond line NintEdanib in non-small cell lung CAncer) trial.
Capelletto E, Migliorino MR, Morabito A, Chiari R, Grossi F, Tiseo M, Costanzo FD, Delmonte A, Romano G, Galetta D, Scotti V, Gregorc V, Pisconti S, Ceresoli GL, Del Conte A, Ciuffreda L, Colantonio I, Bria E, Ricciardi S, Manzo A, Metro G, Morelli AM, Critelli R, Pacchiana MV, Stura I, Migliaretti G, Novello S
Lung Cancer 2019 Aug;134:210-217. Epub 2019 Jun 27 doi: 10.1016/j.lungcan.2019.06.028. PMID: 31319983
Non-small cell lung cancer patients with EML4-ALK fusion gene are insensitive to cytotoxic chemotherapy.
Morodomi Y, Takenoyama M, Inamasu E, Toyozawa R, Kojo M, Toyokawa G, Shiraishi Y, Takenaka T, Hirai F, Yamaguchi M, Taguchi K, Seto T, Sugio K, Ichinose Y
Anticancer Res 2014 Jul;34(7):3825-30. PMID: 24982409

Therapy

Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the CheckMate 9LA randomized trial.
Carbone DP, Ciuleanu TE, Schenker M, Cobo M, Bordenave S, Juan-Vidal O, Menezes J, Reinmuth N, Richardet E, Cheng Y, Mizutani H, Felip E, Zurawski B, Alexandru A, Paz-Ares L, Lu S, John T, Zhang X, Mahmood J, Hu N, De T, Santi I, Penrod JR, Yuan Y, Lee A, Reck M
J Immunother Cancer 2024 Feb 12;12(2) doi: 10.1136/jitc-2023-008189. PMID: 38346853Free PMC Article
Randomized, open-label phase II study of brigatinib and carboplatin plus pemetrexed and brigatinib alone for chemotherapy-naive patients with ALK-rearranged non-squamous non-small cell lung cancer: treatment rationale and protocol design of the B-DASH study (WJOG 14720 L).
Wakuda K, Kenmotsu H, Sato Y, Nakamura A, Akamatsu H, Tachihara M, Miura S, Yokoyama T, Mori K, Nakagawa K, Yamamoto N
BMC Cancer 2023 Sep 25;23(1):902. doi: 10.1186/s12885-023-11417-w. PMID: 37749521Free PMC Article
First-line nivolumab, paclitaxel, carboplatin, and bevacizumab for advanced non-squamous non-small cell lung cancer: Updated survival analysis of the ONO-4538-52/TASUKI-52 randomized controlled trial.
Kim HR, Sugawara S, Lee JS, Kang JH, Inui N, Hida T, Lee KH, Yoshida T, Tanaka H, Yang CT, Nishio M, Ohe Y, Tamura T, Yamamoto N, Yu CJ, Akamatsu H, Takahashi S, Nakagawa K
Cancer Med 2023 Aug;12(16):17061-17067. Epub 2023 Aug 28 doi: 10.1002/cam4.6348. PMID: 37641544Free PMC Article
MYL-1402O: A Bevacizumab Biosimilar.
Lee A
Target Oncol 2022 Jan;17(1):85-88. Epub 2021 Dec 15 doi: 10.1007/s11523-021-00858-7. PMID: 34910269Free PMC Article
Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial.
Saito H, Fukuhara T, Furuya N, Watanabe K, Sugawara S, Iwasawa S, Tsunezuka Y, Yamaguchi O, Okada M, Yoshimori K, Nakachi I, Gemma A, Azuma K, Kurimoto F, Tsubata Y, Fujita Y, Nagashima H, Asai G, Watanabe S, Miyazaki M, Hagiwara K, Nukiwa T, Morita S, Kobayashi K, Maemondo M
Lancet Oncol 2019 May;20(5):625-635. Epub 2019 Apr 8 doi: 10.1016/S1470-2045(19)30035-X. PMID: 30975627

Prognosis

STK11/LKB1 alterations worsen the poor prognosis of KRAS mutated early-stage non-squamous non-small cell lung carcinoma, results based on the phase 2 IFCT TASTE trial.
Oudart JB, Garinet S, Leger C, Barlesi F, Mazières J, Jeannin G, Audigier-Valette C, Morot-Sibilot D, Langlais A, Amour E, Mathiot N, Birsen G, Blons H, Wislez M
Lung Cancer 2024 Apr;190:107508. Epub 2024 Feb 19 doi: 10.1016/j.lungcan.2024.107508. PMID: 38428265
Predictive value of EGFR mutation in non-small-cell lung cancer patients treated with platinum doublet postoperative chemotherapy.
Takahashi T, Sakai K, Kenmotsu H, Yoh K, Daga H, Ohira T, Ueno T, Aoki T, Hayashi H, Yamazaki K, Hosomi Y, Chen-Yoshikawa TF, Okumura N, Takiguchi Y, Sekine A, Haruki T, Yamamoto H, Sato Y, Akamatsu H, Seto T, Saeki S, Sugio K, Nishio M, Inokawa H, Yamamoto N, Nishio K, Tsuboi M
Cancer Sci 2022 Jan;113(1):287-296. Epub 2021 Nov 7 doi: 10.1111/cas.15171. PMID: 34689382Free PMC Article
Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer.
Cui W, Franchini F, Alexander M, Officer A, Wong HL, IJzerman M, Desai J, Solomon BJ
Lung Cancer 2020 Aug;146:310-317. Epub 2020 Jun 26 doi: 10.1016/j.lungcan.2020.06.030. PMID: 32619782
Nivolumab in advanced non-small-cell lung cancer patients who failed prior platinum-based chemotherapy.
Lee JS, Lee KH, Cho EK, Kim DW, Kim SW, Kim JH, Cho BC, Kang JH, Han JY, Min YJ, Park K
Lung Cancer 2018 Aug;122:234-242. Epub 2018 May 24 doi: 10.1016/j.lungcan.2018.05.023. PMID: 30032838
Pemetrexed in the treatment of advanced non-squamous lung cancer.
Rossi A, Ricciardi S, Maione P, de Marinis F, Gridelli C
Lung Cancer 2009 Nov;66(2):141-9. Epub 2009 Jul 4 doi: 10.1016/j.lungcan.2009.06.006. PMID: 19577816

Clinical prediction guides

Five-year outcomes with first-line nivolumab plus ipilimumab with 2 cycles of chemotherapy versus 4 cycles of chemotherapy alone in patients with metastatic non-small cell lung cancer in the randomized CheckMate 9LA trial.
Reck M, Ciuleanu TE, Schenker M, Bordenave S, Cobo M, Juan-Vidal O, Reinmuth N, Richardet E, Felip E, Menezes J, Cheng Y, Mizutani H, Zurawski B, Alexandru A, Carbone DP, Lu S, John T, Aoyama T, Grootendorst DJ, Hu N, Eccles LJ, Paz-Ares LG
Eur J Cancer 2024 Nov;211:114296. Epub 2024 Aug 25 doi: 10.1016/j.ejca.2024.114296. PMID: 39270380
STK11/LKB1 alterations worsen the poor prognosis of KRAS mutated early-stage non-squamous non-small cell lung carcinoma, results based on the phase 2 IFCT TASTE trial.
Oudart JB, Garinet S, Leger C, Barlesi F, Mazières J, Jeannin G, Audigier-Valette C, Morot-Sibilot D, Langlais A, Amour E, Mathiot N, Birsen G, Blons H, Wislez M
Lung Cancer 2024 Apr;190:107508. Epub 2024 Feb 19 doi: 10.1016/j.lungcan.2024.107508. PMID: 38428265
Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the CheckMate 9LA randomized trial.
Carbone DP, Ciuleanu TE, Schenker M, Cobo M, Bordenave S, Juan-Vidal O, Menezes J, Reinmuth N, Richardet E, Cheng Y, Mizutani H, Felip E, Zurawski B, Alexandru A, Paz-Ares L, Lu S, John T, Zhang X, Mahmood J, Hu N, De T, Santi I, Penrod JR, Yuan Y, Lee A, Reck M
J Immunother Cancer 2024 Feb 12;12(2) doi: 10.1136/jitc-2023-008189. PMID: 38346853Free PMC Article
Outcomes of immune checkpoint inhibitors for postoperative recurrence of non-small cell lung cancer.
Yuasa I, Hamaji M, Ozasa H, Sakamori Y, Yoshida H, Yutaka Y, Menju T, Hirai T, Date H
Gen Thorac Cardiovasc Surg 2023 Sep;71(9):534-541. Epub 2023 Feb 22 doi: 10.1007/s11748-023-01920-z. PMID: 36811789
Pemetrexed in the treatment of advanced non-squamous lung cancer.
Rossi A, Ricciardi S, Maione P, de Marinis F, Gridelli C
Lung Cancer 2009 Nov;66(2):141-9. Epub 2009 Jul 4 doi: 10.1016/j.lungcan.2009.06.006. PMID: 19577816

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