U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vulvar Superficial Myofibroblastoma

MedGen UID:
925378
•Concept ID:
C4287846
•
Neoplastic Process

Definition

An uncommon benign polypoid or nodular mesenchymal neoplasm that arises in the vulvar region. It is characterized by the presence of oval or spindle-shaped cells in a collagenous stroma and is separated from the epidermis by a variably thick Grenz zone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar Superficial Myofibroblastoma

Recent clinical studies

Etiology

Update on Mesenchymal Lesions of the Lower Female Genital Tract.
Croce S, Perret R, Le Loarer F
Surg Pathol Clin 2022 Jun;15(2):341-367. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.009. PMID: 35715165
Free latissimus dorsi myocutaneous flap for pelvic floor reconstruction following pelvic exenteration.
Abdou AH, Li L, Khatib-Chahidi K, Troja A, Looft P, Gudewer EM, Raab HR, Antolovic D
Int J Colorectal Dis 2016 Feb;31(2):385-91. Epub 2015 Sep 26 doi: 10.1007/s00384-015-2402-8. PMID: 26410267
Angiomyofibroblastoma of the vulva: case report.
Ustun C, Malazgirt Z, Kandemir B, Kocak I, Bolat I, Gumus S
Pathol Int 1998 Dec;48(12):964-6. doi: 10.1111/j.1440-1827.1998.tb03867.x. PMID: 9952340
Extravulvar subcutaneous cellular angiofibroma.
Garijo MF, Val-Bernal JF
J Cutan Pathol 1998 Jul;25(6):327-32. doi: 10.1111/j.1600-0560.1998.tb01754.x. PMID: 9694623
Angiomyofibroblastomalike tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma.
Laskin WB, Fetsch JF, Mostofi FK
Am J Surg Pathol 1998 Jan;22(1):6-16. doi: 10.1097/00000478-199801000-00002. PMID: 9422311

Diagnosis

Update on Mesenchymal Lesions of the Lower Female Genital Tract.
Croce S, Perret R, Le Loarer F
Surg Pathol Clin 2022 Jun;15(2):341-367. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.009. PMID: 35715165
Giant superficial angiomyxoma of the vulva: a case report and review of the literature.
Kim HS, Kim GY, Lim SJ, Ki KD, Kim HC
J Cutan Pathol 2010 Jun;37(6):672-7. Epub 2009 Jul 13 doi: 10.1111/j.1600-0560.2009.01333.x. PMID: 19615026
Angiomyofibroblastoma of the vulva: case report.
Ustun C, Malazgirt Z, Kandemir B, Kocak I, Bolat I, Gumus S
Pathol Int 1998 Dec;48(12):964-6. doi: 10.1111/j.1440-1827.1998.tb03867.x. PMID: 9952340
Extravulvar subcutaneous cellular angiofibroma.
Garijo MF, Val-Bernal JF
J Cutan Pathol 1998 Jul;25(6):327-32. doi: 10.1111/j.1600-0560.1998.tb01754.x. PMID: 9694623
Superficial stromal reactions of lower genital tract.
Elliott GB, Elliott JD
Arch Pathol 1973 Feb;95(2):100-1. PMID: 4683156

Therapy

Free latissimus dorsi myocutaneous flap for pelvic floor reconstruction following pelvic exenteration.
Abdou AH, Li L, Khatib-Chahidi K, Troja A, Looft P, Gudewer EM, Raab HR, Antolovic D
Int J Colorectal Dis 2016 Feb;31(2):385-91. Epub 2015 Sep 26 doi: 10.1007/s00384-015-2402-8. PMID: 26410267

Prognosis

Vulval superficial myofibroblastoma with lymphocytic and eosinophilic infiltrate.
Tan QT, Morgan T, Scurry JP
BMJ Case Rep 2023 Nov 30;16(11) doi: 10.1136/bcr-2022-248800. PMID: 38035683Free PMC Article
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract.
Laskin WB, Fetsch JF, Tavassoli FA
Hum Pathol 2001 Jul;32(7):715-25. doi: 10.1053/hupa.2001.25588. PMID: 11486170
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053
Angiomyofibroblastomalike tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma.
Laskin WB, Fetsch JF, Mostofi FK
Am J Surg Pathol 1998 Jan;22(1):6-16. doi: 10.1097/00000478-199801000-00002. PMID: 9422311

Clinical prediction guides

Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases.
Zhang M, Shi P, Zhou B, Liu J, Li L
Ann Diagn Pathol 2022 Oct;60:152010. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152010. PMID: 35907316
HMGA2 Is a Useful Marker of Vulvovaginal Aggressive Angiomyxoma But May Be Positive in Other Mesenchymal Lesions at This Site.
Harkness R, McCluggage WG
Int J Gynecol Pathol 2021 Mar 1;40(2):185-189. doi: 10.1097/PGP.0000000000000689. PMID: 32897956
Giant superficial angiomyxoma of the vulva: a case report and review of the literature.
Kim HS, Kim GY, Lim SJ, Ki KD, Kim HC
J Cutan Pathol 2010 Jun;37(6):672-7. Epub 2009 Jul 13 doi: 10.1111/j.1600-0560.2009.01333.x. PMID: 19615026
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Recent systematic reviews

Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases.
Zhang M, Shi P, Zhou B, Liu J, Li L
Ann Diagn Pathol 2022 Oct;60:152010. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152010. PMID: 35907316

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...