U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cloacogenic carcinoma

MedGen UID:
90755
•Concept ID:
C0334273
•
Neoplastic Process
Synonym: Cloacogenic Carcinoma
SNOMED CT: Cloacogenic carcinoma (84570003)
 
Monarch Initiative: MONDO:0004129
OMIM®: 105580

Definition

An anal carcinoma arising from the transitional zone of the anal canal. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCloacogenic carcinoma

Professional guidelines

PubMed

Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center.
Bertani E, Chiappa A, Mazzarol G, Contino G, Lazzari R, Zampino MG, Viale G, Andreoni B
Dig Surg 2010;27(4):297-301. Epub 2010 Jul 31 doi: 10.1159/000288644. PMID: 20689291
Extrauterine malignancies. Role of Pap smears in diagnosis and management.
Gupta D, Balsara G
Acta Cytol 1999 Sep-Oct;43(5):806-13. doi: 10.1159/000331294. PMID: 10518134
Diagnosis and differential diagnosis of small-cell lesions of the liver.
Pisharodi LR, Bedrossian C
Diagn Cytopathol 1998 Jul 1;19(1):29-32. doi: 10.1002/(sici)1097-0339(199807)19:1<29::aid-dc6>3.0.co;2-j. PMID: 9664180

Recent clinical studies

Etiology

Basaloid Squamous Cell Carcinoma of the Anus Revisited.
Graham RP, Arnold CA, Naini BV, Lam-Himlin DM
Am J Surg Pathol 2016 Mar;40(3):354-60. doi: 10.1097/PAS.0000000000000594. PMID: 26866355
The rising incidence of anal cancer in England 1990-2010: a population-based study.
Wilkinson JR, Morris EJ, Downing A, Finan PJ, Aravani A, Thomas JD, Sebag-Montefiore D
Colorectal Dis 2014 Jul;16(7):O234-9. doi: 10.1111/codi.12553. PMID: 24410872
Anal canal carcinoma: experience from a single Korean institution.
Lee WS, Chun HK, Lee WY, Yun SH, Yun H, Cho YB, Kang WK, Park YS, Huh SJ, Ahn YC, Park W
Yonsei Med J 2007 Oct 31;48(5):827-32. doi: 10.3349/ymj.2007.48.5.827. PMID: 17963341Free PMC Article
Anal carcinoma: a 15-year retrospective analysis.
Olofinlade O, Adeonigbagbe O, Gualtieri N, Gingold B, Berlin I, Sayeed R, Robilotti J
Scand J Gastroenterol 2000 Nov;35(11):1194-9. doi: 10.1080/003655200750056682. PMID: 11145292
Anal cloacogenic carcinoma: classification and clinical behavior.
Serota AI, Weil M, Williams RA, Wollman JS, Wilson SE
Arch Surg 1981 Apr;116(4):456-9. doi: 10.1001/archsurg.1981.01380160066013. PMID: 7213001

Diagnosis

A rare case of a superficial squamous cell carcinoma (so-called cloacogenic carcinoma) of the rectum.
Tanaka T, Tajika M, Onishi S, Yamada K, Kamiya T, Hosoda W, Niwa Y
Clin J Gastroenterol 2023 Feb;16(1):48-53. Epub 2022 Oct 28 doi: 10.1007/s12328-022-01717-2. PMID: 36306057
HPV related cloacogenic carcinoma of the anal canal with divergent histomorphology.
Gurumurthy RY, Shankar NS, Mohan Raj CS, Sriram N
Indian J Pathol Microbiol 2019 Jul-Sep;62(3):464-466. doi: 10.4103/IJPM.IJPM_305_18. PMID: 31361242
Basaloid Squamous Cell Carcinoma of the Anus Revisited.
Graham RP, Arnold CA, Naini BV, Lam-Himlin DM
Am J Surg Pathol 2016 Mar;40(3):354-60. doi: 10.1097/PAS.0000000000000594. PMID: 26866355
The retinal lesions of the acquired immune deficiency syndrome.
Friedman AH
Trans Am Ophthalmol Soc 1984;82:447-91. PMID: 6100147Free PMC Article
Cloacogenic carcinoma.
Glickman MG, Margulis AR
Am J Roentgenol Radium Ther Nucl Med 1969 Sep;107(1):175-80. doi: 10.2214/ajr.107.1.175. PMID: 5811555

Therapy

FDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma.
Krengli M, Milia ME, Turri L, Mones E, Bassi MC, Cannillo B, Deantonio L, Sacchetti G, Brambilla M, Inglese E
Radiat Oncol 2010 Feb 6;5:10. doi: 10.1186/1748-717X-5-10. PMID: 20137093Free PMC Article
Anal canal carcinoma: experience from a single Korean institution.
Lee WS, Chun HK, Lee WY, Yun SH, Yun H, Cho YB, Kang WK, Park YS, Huh SJ, Ahn YC, Park W
Yonsei Med J 2007 Oct 31;48(5):827-32. doi: 10.3349/ymj.2007.48.5.827. PMID: 17963341Free PMC Article
Chemotherapy and radiation of anal canal cancer: the first approach.
Eng C, Abbruzzese J, Minsky BD
Surg Oncol Clin N Am 2004 Apr;13(2):309-20, viii. doi: 10.1016/j.soc.2003.12.004. PMID: 15137959
External radiation therapy without chemotherapy in the management of anal cancer.
Martenson JA Jr, Gunderson LL
Cancer 1993 Mar 1;71(5):1736-40. doi: 10.1002/1097-0142(19930301)71:5<1736::aid-cncr2820710506>3.0.co;2-f. PMID: 8448738
Radiotherapy for anal cancer: experience from 1979-1987.
Hughes LL, Rich TA, Delclos L, Ajani JA, Martin RG
Int J Radiat Oncol Biol Phys 1989 Dec;17(6):1153-60. doi: 10.1016/0360-3016(89)90520-8. PMID: 2599903

Prognosis

The rising incidence of anal cancer in England 1990-2010: a population-based study.
Wilkinson JR, Morris EJ, Downing A, Finan PJ, Aravani A, Thomas JD, Sebag-Montefiore D
Colorectal Dis 2014 Jul;16(7):O234-9. doi: 10.1111/codi.12553. PMID: 24410872
Anal carcinoma: a 15-year retrospective analysis.
Olofinlade O, Adeonigbagbe O, Gualtieri N, Gingold B, Berlin I, Sayeed R, Robilotti J
Scand J Gastroenterol 2000 Nov;35(11):1194-9. doi: 10.1080/003655200750056682. PMID: 11145292
The retinal lesions of the acquired immune deficiency syndrome.
Friedman AH
Trans Am Ophthalmol Soc 1984;82:447-91. PMID: 6100147Free PMC Article
Anal cloacogenic carcinoma: classification and clinical behavior.
Serota AI, Weil M, Williams RA, Wollman JS, Wilson SE
Arch Surg 1981 Apr;116(4):456-9. doi: 10.1001/archsurg.1981.01380160066013. PMID: 7213001
Cloacogenic carcinoma.
Sink JD, Kramer SA, Copeland DD, Seigler HF
Ann Surg 1978 Jul;188(1):53-9. doi: 10.1097/00000658-197807000-00009. PMID: 666378Free PMC Article

Clinical prediction guides

A rare case of a superficial squamous cell carcinoma (so-called cloacogenic carcinoma) of the rectum.
Tanaka T, Tajika M, Onishi S, Yamada K, Kamiya T, Hosoda W, Niwa Y
Clin J Gastroenterol 2023 Feb;16(1):48-53. Epub 2022 Oct 28 doi: 10.1007/s12328-022-01717-2. PMID: 36306057
Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes.
Gurzu S, Szentirmay Z, Bara T, Bara T Jr, Iurcsuk O, Jung I
Eur J Gastroenterol Hepatol 2014 May;26(5):570-3. doi: 10.1097/MEG.0000000000000064. PMID: 24584270
Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center.
Bertani E, Chiappa A, Mazzarol G, Contino G, Lazzari R, Zampino MG, Viale G, Andreoni B
Dig Surg 2010;27(4):297-301. Epub 2010 Jul 31 doi: 10.1159/000288644. PMID: 20689291
The retinal lesions of the acquired immune deficiency syndrome.
Friedman AH
Trans Am Ophthalmol Soc 1984;82:447-91. PMID: 6100147Free PMC Article
Histogenesis of cloacogenic carcinoma. Fine structure of anal transitional epithelium and cloacogenic carcinoma.
Gillespie JJ, MacKay B
Hum Pathol 1978 Sep;9(5):579-87. doi: 10.1016/s0046-8177(78)80138-5. PMID: 711233

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...