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Liver Iron Concentration

MedGen UID:
906036
•Concept ID:
C4086551
•
Finding
Synonyms: Hepatic Iron Concentration; LIC

Definition

A measurement of the concentration of iron in the liver as an estimate of body iron load. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Iron Concentration

Professional guidelines

PubMed

Iron Chelation Therapy as a Modality of Management.
Aydinok Y
Hematol Oncol Clin North Am 2018 Apr;32(2):261-275. Epub 2018 Jan 17 doi: 10.1016/j.hoc.2017.12.002. PMID: 29458731
Characterization of hepatic and cardiac iron deposition during standard treatment of anaemia in haemodialysis.
Holman R, Olynyk JK, Kulkarni H, Ferrari P
Nephrology (Carlton) 2017 Feb;22(2):114-117. doi: 10.1111/nep.12735. PMID: 26824431
Consequences and management of iron overload in sickle cell disease.
Porter J, Garbowski M
Hematology Am Soc Hematol Educ Program 2013;2013:447-56. doi: 10.1182/asheducation-2013.1.447. PMID: 24319218

Recent clinical studies

Etiology

Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis.
Rostoker G, Dekeyser M, Francisco S, Loridon C, Griuncelli M, Languille-Llitjos E, Boulahia G, Cohen Y
EBioMedicine 2024 Jan;99:104929. Epub 2023 Dec 20 doi: 10.1016/j.ebiom.2023.104929. PMID: 38128412Free PMC Article
Thalassemia Intermedia: Chelator or Not?
Lee YC, Yen CT, Lee YL, Chen RJ
Int J Mol Sci 2022 Sep 5;23(17) doi: 10.3390/ijms231710189. PMID: 36077584Free PMC Article
MRI for Liver Iron Quantification: Concepts and Current Methods.
Amin K, Mileto A, Kolokythas O
Semin Ultrasound CT MR 2022 Aug;43(4):364-370. Epub 2022 Mar 18 doi: 10.1053/j.sult.2022.03.006. PMID: 35738822
Guidelines for quantifying iron overload.
Wood JC
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):210-5. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.210. PMID: 25696857
Hereditary hemochromatosis.
Fix OK, Kowdley KV
Minerva Med 2008 Dec;99(6):605-17. PMID: 19034258

Diagnosis

Rusfertide for the treatment of iron overload in HFE-related haemochromatosis: an open-label, multicentre, proof-of-concept phase 2 trial.
Kowdley KV, Modi NB, Peltekian K, Vierling JM, Ferris C, Valone FH, Gupta S
Lancet Gastroenterol Hepatol 2023 Dec;8(12):1118-1128. Epub 2023 Oct 17 doi: 10.1016/S2468-1253(23)00250-9. PMID: 37863080
Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR.
Reeder SB, Yokoo T, França M, Hernando D, Alberich-Bayarri Á, Alústiza JM, Gandon Y, Henninger B, Hillenbrand C, Jhaveri K, Karçaaltıncaba M, Kühn JP, Mojtahed A, Serai SD, Ward R, Wood JC, Yamamura J, Martí-Bonmatí L
Radiology 2023 Apr;307(1):e221856. Epub 2023 Feb 21 doi: 10.1148/radiol.221856. PMID: 36809220Free PMC Article
MR imaging assessment and quantification of liver iron.
França M, Carvalho JG
Abdom Radiol (NY) 2020 Nov;45(11):3400-3412. doi: 10.1007/s00261-020-02574-8. PMID: 32435848
Diagnosis and quantification of the iron overload through Magnetic resonance.
Alústiza Echeverría JM, Barrera Portillo MC, Guisasola Iñiguiz A, Ugarte Muño A
Radiologia 2017 Nov-Dec;59(6):487-495. Epub 2017 Sep 18 doi: 10.1016/j.rx.2017.07.003. PMID: 28923493
Hereditary hemochromatosis.
Fix OK, Kowdley KV
Minerva Med 2008 Dec;99(6):605-17. PMID: 19034258

Therapy

Rusfertide for the treatment of iron overload in HFE-related haemochromatosis: an open-label, multicentre, proof-of-concept phase 2 trial.
Kowdley KV, Modi NB, Peltekian K, Vierling JM, Ferris C, Valone FH, Gupta S
Lancet Gastroenterol Hepatol 2023 Dec;8(12):1118-1128. Epub 2023 Oct 17 doi: 10.1016/S2468-1253(23)00250-9. PMID: 37863080
Thalassemia Intermedia: Chelator or Not?
Lee YC, Yen CT, Lee YL, Chen RJ
Int J Mol Sci 2022 Sep 5;23(17) doi: 10.3390/ijms231710189. PMID: 36077584Free PMC Article
Iron Overload and Chelation Therapy in Non-Transfusion Dependent Thalassemia.
Bou-Fakhredin R, Bazarbachi AH, Chaya B, Sleiman J, Cappellini MD, Taher AT
Int J Mol Sci 2017 Dec 20;18(12) doi: 10.3390/ijms18122778. PMID: 29261151Free PMC Article
Deferiprone.
Piga A, Roggero S, Salussolia I, Massano D, Serra M, Longo F
Ann N Y Acad Sci 2010 Aug;1202:75-8. doi: 10.1111/j.1749-6632.2010.05586.x. PMID: 20712776
Deferasirox: an update.
Porter JB
Hemoglobin 2009;33 Suppl 1:S70-5. doi: 10.3109/03630260903347146. PMID: 20001635

Prognosis

Relaxivity-iron calibration in hepatic iron overload: Reproducibility and extension of a Monte Carlo model.
Wang C, Reeder SB, Hernando D
NMR Biomed 2021 Dec;34(12):e4604. Epub 2021 Aug 30 doi: 10.1002/nbm.4604. PMID: 34462976Free PMC Article
Improving CPMG liver iron estimates with a T1 -corrected proton density estimator.
Doyle EK, Thornton S, Toy KA, Powell AJ, Wood JC
Magn Reson Med 2021 Dec;86(6):3348-3359. Epub 2021 Jul 29 doi: 10.1002/mrm.28943. PMID: 34324729Free PMC Article
When should iron supplementation in dialysis patients be avoided, minimized or withdrawn?
Rostoker G
Semin Dial 2019 Jan;32(1):22-29. Epub 2018 Jun 28 doi: 10.1111/sdi.12732. PMID: 29956370Free PMC Article
Hepatocellular carcinoma as an emerging morbidity in the thalassemia syndromes: A comprehensive review.
Moukhadder HM, Halawi R, Cappellini MD, Taher AT
Cancer 2017 Mar 1;123(5):751-758. Epub 2016 Dec 1 doi: 10.1002/cncr.30462. PMID: 27911488
Evaluation and interpretation of iron in the liver.
Turlin B, Deugnier Y
Semin Diagn Pathol 1998 Nov;15(4):237-45. PMID: 9845425

Clinical prediction guides

Pregnancy outcomes and iron status in β-thalassemia major and intermedia: a systematic review and meta-analysis.
Vlachodimitropoulou E, Mogharbel H, Kuo KHM, Hwang M, Ward R, Shehata N, Malinowski AK
Blood Adv 2024 Feb 13;8(3):746-757. doi: 10.1182/bloodadvances.2023011636. PMID: 38181780Free PMC Article
Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis.
Rostoker G, Dekeyser M, Francisco S, Loridon C, Griuncelli M, Languille-Llitjos E, Boulahia G, Cohen Y
EBioMedicine 2024 Jan;99:104929. Epub 2023 Dec 20 doi: 10.1016/j.ebiom.2023.104929. PMID: 38128412Free PMC Article
Magnetic Resonance Liver Iron Concentration Can Guide Venesection Decision-Making in Hyperferritinemia.
Bhuva M, Patterson I, Godfrey EM, Bowden DJ, Griffiths WJH
Dig Dis Sci 2023 Jun;68(6):2704-2709. Epub 2023 Mar 17 doi: 10.1007/s10620-023-07873-w. PMID: 36929239
Iron Chelation Therapy as a Modality of Management.
Aydinok Y
Hematol Oncol Clin North Am 2018 Apr;32(2):261-275. Epub 2018 Jan 17 doi: 10.1016/j.hoc.2017.12.002. PMID: 29458731
Iatrogenic iron overload and its potential consequences in patients on hemodialysis.
Rostoker G, Vaziri ND
Presse Med 2017 Dec;46(12 Pt 2):e312-e328. Epub 2017 Nov 16 doi: 10.1016/j.lpm.2017.10.014. PMID: 29153377

Recent systematic reviews

Pregnancy outcomes and iron status in β-thalassemia major and intermedia: a systematic review and meta-analysis.
Vlachodimitropoulou E, Mogharbel H, Kuo KHM, Hwang M, Ward R, Shehata N, Malinowski AK
Blood Adv 2024 Feb 13;8(3):746-757. doi: 10.1182/bloodadvances.2023011636. PMID: 38181780Free PMC Article
Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion-dependent beta thalassaemia.
Padhani ZA, Gangwani MK, Sadaf A, Hasan B, Colan S, Alvi N, Das JK
Cochrane Database Syst Rev 2023 Nov 17;11(11):CD011626. doi: 10.1002/14651858.CD011626.pub3. PMID: 37975597Free PMC Article
Efficacy and safety of calcium channel blockers in preventing cardiac siderosis in thalassemia patients: An updated meta-analysis with trial sequential analysis.
Soliman Y, Abdelaziz A, Mouffokes A, Amer BE, Goudy YM, Abdelwahab OA, Badawy MM, Diab RA, Elsharkawy A
Eur J Haematol 2023 Apr;110(4):414-425. Epub 2023 Jan 2 doi: 10.1111/ejh.13919. PMID: 36565288
Accuracy of magnetic resonance imaging in diagnosis of liver iron overload: a systematic review and meta-analysis.
Sarigianni M, Liakos A, Vlachaki E, Paschos P, Athanasiadou E, Montori VM, Murad MH, Tsapas A
Clin Gastroenterol Hepatol 2015 Jan;13(1):55-63.e5. Epub 2014 Jun 30 doi: 10.1016/j.cgh.2014.05.027. PMID: 24993364
Deferasirox for managing transfusional iron overload in people with sickle cell disease.
Meerpohl JJ, Antes G, Rücker G, Fleeman N, Niemeyer C, Bassler D
Cochrane Database Syst Rev 2010 Aug 4;(8):CD007477. doi: 10.1002/14651858.CD007477.pub2. PMID: 20687088

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