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Graham Little-Piccardi-Lassueur syndrome

MedGen UID:
905915
Concept ID:
C4273658
Disease or Syndrome
Synonym: Picardi-Lassueur-Little syndrome
SNOMED CT: Graham Little Piccardi Lassueur syndrome (718215008); Graham Little syndrome (718215008); Piccardi Lassueur Little syndrome (718215008)
 
Monarch Initiative: MONDO:0018858
Orphanet: ORPHA505

Definition

A variant of lichen planopilaris characterized by the clinical triad of progressive cicatricial (scarring) alopecia of the scalp, follicular keratotic papules on glabrous skin, and variable alopecia of the axillae and groin. It is a very rare disease but the exact prevalence is not known. It mainly affects women during adulthood (30-60 years of age). Scarring alopecia presents as small confluent patches that are atrophic and cicatricial in the center but erythematous and squamous around the edges. Follicular keratosis presents as pruritic, red-brown, follicular spiny papules on the trunk and extremities. Generally, the three clinical features appear simultaneously but in some cases, scalp alopecia precedes the follicular keratosis. Etiology is unknown. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGraham Little-Piccardi-Lassueur syndrome

Professional guidelines

PubMed

Babahosseini H, Tavakolpour S, Mahmoudi H, Balighi K, Teimourpour A, Ghodsi SZ, Abedini R, Ghandi N, Lajevardi V, Kiani A, Kamyab K, Mohammadi M, Daneshpazhooh M
J Dermatolog Treat 2019 Sep;30(6):598-604. Epub 2019 Jan 4 doi: 10.1080/09546634.2018.1542480. PMID: 30411987
Baibergenova A, Donovan J
Skinmed 2013 May-Jun;11(3):161-5. PMID: 23930355
Assouly P, Reygagne P
Semin Cutan Med Surg 2009 Mar;28(1):3-10. doi: 10.1016/j.sder.2008.12.006. PMID: 19341936

Recent clinical studies

Etiology

Basu A, Basu D, Chattopadhyay A, Sanyal R, Rahman M, Goswami RP
Drug Discov Ther 2019 Nov 14;13(5):294-296. Epub 2019 Oct 27 doi: 10.5582/ddt.2019.01055. PMID: 31656251
Babahosseini H, Tavakolpour S, Mahmoudi H, Balighi K, Teimourpour A, Ghodsi SZ, Abedini R, Ghandi N, Lajevardi V, Kiani A, Kamyab K, Mohammadi M, Daneshpazhooh M
J Dermatolog Treat 2019 Sep;30(6):598-604. Epub 2019 Jan 4 doi: 10.1080/09546634.2018.1542480. PMID: 30411987
Mardones F, Shapiro J
Clin Exp Dermatol 2017 Oct;42(7):755-759. Epub 2017 Jul 27 doi: 10.1111/ced.13203. PMID: 28748570
Soares VC, Mulinari-Brenner F, Souza TE
An Bras Dermatol 2015 Sep-Oct;90(5):666-70. doi: 10.1590/abd1806-4841.20153923. PMID: 26560212Free PMC Article
Meinhard J, Stroux A, Lünnemann L, Vogt A, Blume-Peytavi U
J Dtsch Dermatol Ges 2014 Mar;12(3):229-35, 229-36. Epub 2014 Feb 17 doi: 10.1111/ddg.12264. PMID: 24533855

Diagnosis

Antonio JR, Lucca LC, Borim MP, Rossi NC, Oliveira GB
An Bras Dermatol 2014 Nov-Dec;89(6):1003-4. doi: 10.1590/abd1806-4841.20143156. PMID: 25387513Free PMC Article
Baibergenova A, Donovan J
Skinmed 2013 May-Jun;11(3):161-5. PMID: 23930355
Steglich RB, Tonoli RE, Pinto GM, Müller FM, Guarenti IM, Duvelius ES
An Bras Dermatol 2012 Sep-Oct;87(5):775-7. doi: 10.1590/s0365-05962012000500019. PMID: 23044575
Vashi N, Newlove T, Chu J, Patel R, Stein J
Dermatol Online J 2011 Oct 15;17(10):30. PMID: 22031656
Vega Gutiérrez J, Miranda-Romero A, Pérez Milán F, Martínez García G
J Eur Acad Dermatol Venereol 2004 Jul;18(4):463-6. doi: 10.1111/j.1468-3083.2004.00945.x. PMID: 15196163

Therapy

Babahosseini H, Tavakolpour S, Mahmoudi H, Balighi K, Teimourpour A, Ghodsi SZ, Abedini R, Ghandi N, Lajevardi V, Kiani A, Kamyab K, Mohammadi M, Daneshpazhooh M
J Dermatolog Treat 2019 Sep;30(6):598-604. Epub 2019 Jan 4 doi: 10.1080/09546634.2018.1542480. PMID: 30411987
Antonio JR, Lucca LC, Borim MP, Rossi NC, Oliveira GB
An Bras Dermatol 2014 Nov-Dec;89(6):1003-4. doi: 10.1590/abd1806-4841.20143156. PMID: 25387513Free PMC Article
Baibergenova A, Donovan J
Skinmed 2013 May-Jun;11(3):161-5. PMID: 23930355
Vashi N, Newlove T, Chu J, Patel R, Stein J
Dermatol Online J 2011 Oct 15;17(10):30. PMID: 22031656
Zegarska B, Kallas D, Schwartz RA, Czajkowski R, Uchanska G, Placek W
Acta Dermatovenerol Alp Pannonica Adriat 2010 Oct;19(3):39-42. PMID: 20976421

Clinical prediction guides

Patel AB, Solomon AR, Mauro MJ, Ehst BD
Dermatology 2016;232(1):122-5. Epub 2015 Sep 10 doi: 10.1159/000437383. PMID: 26352467
Soares VC, Mulinari-Brenner F, Souza TE
An Bras Dermatol 2015 Sep-Oct;90(5):666-70. doi: 10.1590/abd1806-4841.20153923. PMID: 26560212Free PMC Article
Bianchi L, Paro Vidolin A, Piemonte P, Carboni I, Chimenti S
Clin Exp Dermatol 2001 Sep;26(6):518-20. doi: 10.1046/j.1365-2230.2001.00881.x. PMID: 11678880

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