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Cerumen abnormality

MedGen UID:
901975
•Concept ID:
C4280769
•
Finding
HPO: HP:0030787

Definition

Any anomaly of the cerumen (ear wax), the yellowish waxy substance secreted in the ear canal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerumen abnormality

Professional guidelines

PubMed

Clinical Practice Guideline: Age-Related Hearing Loss.
Tsai Do BS, Bush ML, Weinreich HM, Schwartz SR, Anne S, Adunka OF, Bender K, Bold KM, Brenner MJ, Hashmi AZ, Keenan TA, Kim AH, Moore DJ, Nieman CL, Palmer CV, Ross EJ, Steenerson KK, Zhan KY, Reyes J, Dhepyasuwan N
Otolaryngol Head Neck Surg 2024 May;170 Suppl 2:S1-S54. doi: 10.1002/ohn.750. PMID: 38687845
Clinical Practice Guideline: Age-Related Hearing Loss Executive Summary.
Tsai Do BS, Bush ML, Weinreich HM, Schwartz SR, Anne S, Adunka OF, Bender K, Bold KM, Brenner MJ, Hashmi AZ, Kim AH, Keenan TA, Moore DJ, Nieman CL, Palmer CV, Ross EJ, Steenerson KK, Zhan KY, Reyes J, Dhepyasuwan N
Otolaryngol Head Neck Surg 2024 May;170(5):1209-1227. doi: 10.1002/ohn.749. PMID: 38682789
Hearing Loss in Adults: Differential Diagnosis and Treatment.
Michels TC, Duffy MT, Rogers DJ
Am Fam Physician 2019 Jul 15;100(2):98-108. PMID: 31305044

Recent clinical studies

Etiology

Clinical Practice Guideline: Age-Related Hearing Loss.
Tsai Do BS, Bush ML, Weinreich HM, Schwartz SR, Anne S, Adunka OF, Bender K, Bold KM, Brenner MJ, Hashmi AZ, Keenan TA, Kim AH, Moore DJ, Nieman CL, Palmer CV, Ross EJ, Steenerson KK, Zhan KY, Reyes J, Dhepyasuwan N
Otolaryngol Head Neck Surg 2024 May;170 Suppl 2:S1-S54. doi: 10.1002/ohn.750. PMID: 38687845
Pilot Hearing Screening of School-age Children in Lagos, Nigeria.
Skarzynski PH, Swierniak W, Gos E, Bienkowska K, Adeyinka P, Olubi O, Afolabi S, Skarzynska MB, Hatzopoulos S
J Health Care Poor Underserved 2021;32(3):1444-1460. doi: 10.1353/hpu.2021.0143. PMID: 34421042
Cerumen impaction was composed of abnormal exfoliation of keratinocytes that was correlated with infection.
Zhang S, Jin M, Zhou G, Zhang Y
Am J Otolaryngol 2020 Mar-Apr;41(2):102340. Epub 2019 Nov 7 doi: 10.1016/j.amjoto.2019.102340. PMID: 31735444
External Auditory Canal Dimensions, Age, and Cerumen Retention or Impaction in Persons With Down Syndrome.
Dy AES, Lapeña JFF Jr
Ann Otol Rhinol Laryngol 2018 Apr;127(4):253-257. Epub 2018 Feb 9 doi: 10.1177/0003489418756678. PMID: 29426243
Etiology of breast cancer. I. Genetic aspects.
Vakil DV, Morgan RW
Can Med Assoc J 1973 Jul 7;109(1):29-32. PMID: 4577599Free PMC Article

Diagnosis

Clinical Practice Guideline: Age-Related Hearing Loss.
Tsai Do BS, Bush ML, Weinreich HM, Schwartz SR, Anne S, Adunka OF, Bender K, Bold KM, Brenner MJ, Hashmi AZ, Keenan TA, Kim AH, Moore DJ, Nieman CL, Palmer CV, Ross EJ, Steenerson KK, Zhan KY, Reyes J, Dhepyasuwan N
Otolaryngol Head Neck Surg 2024 May;170 Suppl 2:S1-S54. doi: 10.1002/ohn.750. PMID: 38687845
Otoscopy and tympanometry outcomes from the National Health and Nutrition Examination Survey (NHANES).
McManus B, Harbarger C, Grillis A, Prewitt MG, Baiduc R, Block D, Paul O, Spankovich C
Am J Otolaryngol 2022 Mar-Apr;43(2):103332. Epub 2021 Dec 14 doi: 10.1016/j.amjoto.2021.103332. PMID: 34953248
Analysis of cannabinoids in conventional and alternative biological matrices by liquid chromatography: Applications and challenges.
Nicolaou AG, Christodoulou MC, Stavrou IJ, Kapnissi-Christodoulou CP
J Chromatogr A 2021 Aug 16;1651:462277. Epub 2021 May 24 doi: 10.1016/j.chroma.2021.462277. PMID: 34091369
Hearing Loss in Adults: Differential Diagnosis and Treatment.
Michels TC, Duffy MT, Rogers DJ
Am Fam Physician 2019 Jul 15;100(2):98-108. PMID: 31305044
Diagnostic approach to tinnitus.
Crummer RW, Hassan GA
Am Fam Physician 2004 Jan 1;69(1):120-6. PMID: 14727828

Therapy

Down Syndrome for the Otolaryngologist: A Review.
Zalzal HG, Lawlor CM
JAMA Otolaryngol Head Neck Surg 2023 Apr 1;149(4):360-367. doi: 10.1001/jamaoto.2023.0001. PMID: 36862403
Cerumen impaction was composed of abnormal exfoliation of keratinocytes that was correlated with infection.
Zhang S, Jin M, Zhou G, Zhang Y
Am J Otolaryngol 2020 Mar-Apr;41(2):102340. Epub 2019 Nov 7 doi: 10.1016/j.amjoto.2019.102340. PMID: 31735444
Using anxiolytics in a pediatric otolaryngology clinic to avoid the operating room.
Orb Q, Rezaie A, Furst S, Meier JD, Park AH
Int J Pediatr Otorhinolaryngol 2019 May;120:73-77. Epub 2019 Feb 5 doi: 10.1016/j.ijporl.2019.02.014. PMID: 30772615
Assessment of common otolaryngological diseases among children in rural primary schools in south eastern Nigeria.
Ukaegbe OC, Umedum NG, Chime EN, Orji FT
Int J Pediatr Otorhinolaryngol 2016 Oct;89:169-72. Epub 2016 Aug 24 doi: 10.1016/j.ijporl.2016.08.015. PMID: 27619051
Sensory neural hearing loss in beta-thalassemia major patients treated with deferoxamine.
Shamsian BS, Aminasnafi A, Moghadassian H, Gachkar L, Arzanian MT, Alavi S, Esfehani H, Garallahi F, Amini R
Pediatr Hematol Oncol 2008 Sep;25(6):502-8. doi: 10.1080/08880010802234911. PMID: 18728969

Prognosis

A Web-Based Deep Learning Model for Automated Diagnosis of Otoscopic Images.
Tsutsumi K, Goshtasbi K, Risbud A, Khosravi P, Pang JC, Lin HW, Djalilian HR, Abouzari M
Otol Neurotol 2021 Oct 1;42(9):e1382-e1388. doi: 10.1097/MAO.0000000000003210. PMID: 34191783Free PMC Article
Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma?
Nakagawa H, Toyoda Y, Albrecht T, Tsukamoto M, Praetorius M, Ishikawa T, Kamiya K, Kusunoki T, Ikeda K, Sertel S
Med Hypotheses 2018 May;114:19-22. Epub 2018 Feb 24 doi: 10.1016/j.mehy.2018.02.030. PMID: 29602456
Otologic and audiologic manifestations of Hutchinson-Gilford progeria syndrome.
Guardiani E, Zalewski C, Brewer C, Merideth M, Introne W, Smith AC, Gordon L, Gahl W, Kim HJ
Laryngoscope 2011 Oct;121(10):2250-5. Epub 2011 Sep 6 doi: 10.1002/lary.22151. PMID: 21898437Free PMC Article
Hearing impairment and poverty: the epidemiology of ear disease in Peruvian schoolchildren.
Czechowicz JA, Messner AH, Alarcon-Matutti E, Alarcon J, Quinones-Calderon G, Montano S, Zunt JR
Otolaryngol Head Neck Surg 2010 Feb;142(2):272-7. doi: 10.1016/j.otohns.2009.10.040. PMID: 20115987Free PMC Article
A study on the otoscopical and audiological findings in patients with Down's syndrome in Greece.
Maroudias N, Economides J, Christodoulou P, Helidonis E
Int J Pediatr Otorhinolaryngol 1994 Mar;29(1):43-9. doi: 10.1016/0165-5876(94)90107-4. PMID: 8169046

Clinical prediction guides

Down Syndrome for the Otolaryngologist: A Review.
Zalzal HG, Lawlor CM
JAMA Otolaryngol Head Neck Surg 2023 Apr 1;149(4):360-367. doi: 10.1001/jamaoto.2023.0001. PMID: 36862403
A Web-Based Deep Learning Model for Automated Diagnosis of Otoscopic Images.
Tsutsumi K, Goshtasbi K, Risbud A, Khosravi P, Pang JC, Lin HW, Djalilian HR, Abouzari M
Otol Neurotol 2021 Oct 1;42(9):e1382-e1388. doi: 10.1097/MAO.0000000000003210. PMID: 34191783Free PMC Article
Building an Otoscopic screening prototype tool using deep learning.
Livingstone D, Talai AS, Chau J, Forkert ND
J Otolaryngol Head Neck Surg 2019 Nov 26;48(1):66. doi: 10.1186/s40463-019-0389-9. PMID: 31771647Free PMC Article
Hearing Loss in Adults: Differential Diagnosis and Treatment.
Michels TC, Duffy MT, Rogers DJ
Am Fam Physician 2019 Jul 15;100(2):98-108. PMID: 31305044
Audiologic evaluation of deaf children.
Erber NP, Alencewicz CM
J Speech Hear Disord 1976 May;41(2):256-67. doi: 10.1044/jshd.4102.256. PMID: 942611

Supplemental Content

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