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Frontal fibrosing alopecia

MedGen UID:
899012
Concept ID:
C4255374
Disease or Syndrome
Synonyms: FFA; frontal fibrosing alopecia
SNOMED CT: Frontal fibrosing alopecia (717055000)
 
Monarch Initiative: MONDO:0016776
Orphanet: ORPHA254492

Definition

A rare variant of lichen planopilaris with characteristic of symmetrical progressive band-like anterior hair loss of the scalp. Prevalence is unknown. It most commonly affects postmenopausal women, although it has also been reported in men and premenopausal women. Progressive recession of the frontal and temporal hairline is observed. Approximately half of all cases also have eyebrow loss; less often there is hair loss in other parts of the body. It is only very rarely associated with classic lichen planus lesions elsewhere. It is suggested that the disease could have a hormonal origin, but to date the precise cause remains unknown. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFrontal fibrosing alopecia

Professional guidelines

PubMed

Moussa A, Bhoyrul B, Asfour L, Kazmi A, Eisman S, Sinclair RD
J Am Acad Dermatol 2022 Sep;87(3):663-666. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2022.02.027. PMID: 35202778
Villani A, Fabbrocini G, Ocampo-Candiani J, Ruggiero A, Ocampo-Garza SS
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1485-1492. Epub 2021 Mar 23 doi: 10.1111/jdv.17216. PMID: 33660357
Wolff H, Fischer TW, Blume-Peytavi U
Dtsch Arztebl Int 2016 May 27;113(21):377-86. doi: 10.3238/arztebl.2016.0377. PMID: 27504707Free PMC Article

Recent clinical studies

Etiology

Moussa A, Bhoyrul B, Asfour L, Kazmi A, Eisman S, Sinclair RD
J Am Acad Dermatol 2022 Sep;87(3):663-666. Epub 2022 Feb 22 doi: 10.1016/j.jaad.2022.02.027. PMID: 35202778
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159
Vañó-Galván S, Camacho F
Actas Dermosifiliogr 2017 Apr;108(3):221-228. Epub 2017 Jan 3 doi: 10.1016/j.ad.2016.11.010. PMID: 28061966
Rigopoulos D, Stamatios G, Ioannides D
Curr Probl Dermatol 2015;47:76-86. Epub 2015 Feb 20 doi: 10.1159/000369407. PMID: 26370646

Diagnosis

Larrondo J, McMichael AJ
Dermatol Clin 2023 Jul;41(3):519-537. Epub 2023 Apr 14 doi: 10.1016/j.det.2023.02.007. PMID: 37236719
Fernández-Domper L, Ballesteros-Redondo M, Vañó-Galván S
Actas Dermosifiliogr 2023 Apr;114(4):327-333. Epub 2022 Dec 24 doi: 10.1016/j.ad.2022.12.003. PMID: 36574917
Fechine COC, Valente NYS, Romiti R
An Bras Dermatol 2022 May-Jun;97(3):348-357. Epub 2022 Apr 2 doi: 10.1016/j.abd.2021.08.008. PMID: 35379508Free PMC Article
Alessandrini A, Bruni F, Piraccini BM, Starace M
J Eur Acad Dermatol Venereol 2021 Mar;35(3):629-640. Epub 2021 Jan 8 doi: 10.1111/jdv.17079. PMID: 33290611
Griggs J, Trüeb RM, Gavazzoni Dias MFR, Hordinsky M, Tosti A
J Am Acad Dermatol 2021 Dec;85(6):1557-1564. Epub 2020 Jan 8 doi: 10.1016/j.jaad.2019.12.056. PMID: 31926219

Therapy

Kamp E, Ashraf M, Musbahi E, DeGiovanni C
Clin Exp Dermatol 2022 Dec;47(12):2110-2116. Epub 2022 Oct 28 doi: 10.1111/ced.15327. PMID: 35796569Free PMC Article
Kępińska K, Jałowska M, Bowszyc-Dmochowska M
Ann Agric Environ Med 2022 Jun 24;29(2):169-184. Epub 2021 Aug 31 doi: 10.26444/aaem/141324. PMID: 35767748
Ryan GE, Harris JE, Richmond JM
Front Immunol 2021;12:652191. Epub 2021 May 3 doi: 10.3389/fimmu.2021.652191. PMID: 34012438Free PMC Article
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
Wolff H, Fischer TW, Blume-Peytavi U
Dtsch Arztebl Int 2016 May 27;113(21):377-86. doi: 10.3238/arztebl.2016.0377. PMID: 27504707Free PMC Article

Prognosis

Kępińska K, Jałowska M, Bowszyc-Dmochowska M
Ann Agric Environ Med 2022 Jun 24;29(2):169-184. Epub 2021 Aug 31 doi: 10.26444/aaem/141324. PMID: 35767748
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Alessandrini A, Bruni F, Piraccini BM, Starace M
J Eur Acad Dermatol Venereol 2021 Mar;35(3):629-640. Epub 2021 Jan 8 doi: 10.1111/jdv.17079. PMID: 33290611
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J
Int J Dermatol 2018 May;57(5):505-514. Epub 2017 Oct 26 doi: 10.1111/ijd.13806. PMID: 29076159
To D, Beecker J
J Cutan Med Surg 2018 Mar/Apr;22(2):182-189. Epub 2017 Oct 23 doi: 10.1177/1203475417736279. PMID: 29056083

Clinical prediction guides

Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Vañó-Galván S, Pirmez R, Hermosa-Gelbard A, Moreno-Arrones ÓM, Saceda-Corralo D, Rodrigues-Barata R, Jimenez-Cauhe J, Koh WL, Poa JE, Jerjen R, Trindade de Carvalho L, John JM, Salas-Callo CI, Vincenzi C, Yin L, Lo-Sicco K, Waskiel-Burnat A, Starace M, Zamorano JL, Jaén-Olasolo P, Piraccini BM, Rudnicka L, Shapiro J, Tosti A, Sinclair R, Bhoyrul B
J Am Acad Dermatol 2021 Jun;84(6):1644-1651. Epub 2021 Feb 24 doi: 10.1016/j.jaad.2021.02.054. PMID: 33639244
Robinson G, McMichael A, Wang SQ, Lim HW
J Am Acad Dermatol 2020 Mar;82(3):723-728. Epub 2019 Oct 22 doi: 10.1016/j.jaad.2019.09.085. PMID: 31654665
Moreno-Arrones OM, Saceda-Corralo D, Fonda-Pascual P, Rodrigues-Barata AR, Buendía-Castaño D, Alegre-Sánchez A, Pindado-Ortega C, Molins M, Perosanz D, Segurado-Miravalles G, Jaén P, Vañó-Galván S
J Eur Acad Dermatol Venereol 2017 Oct;31(10):1739-1745. Epub 2017 May 15 doi: 10.1111/jdv.14287. PMID: 28426907
Esteban-Lucía L, Molina-Ruiz AM, Requena L
Actas Dermosifiliogr 2017 May;108(4):293-304. Epub 2017 Jan 20 doi: 10.1016/j.ad.2016.11.012. PMID: 28117051

Recent systematic reviews

Seo HM, Oh SU, Kim S, Park JH, Kim JS
J Eur Acad Dermatol Venereol 2024 Aug;38(8):1514-1521. Epub 2024 Feb 15 doi: 10.1111/jdv.19802. PMID: 38357767
Kam O, Na S, Guo W, Tejeda CI, Kaufmann T
Arch Dermatol Res 2023 Oct;315(8):2313-2331. Epub 2023 Apr 4 doi: 10.1007/s00403-023-02604-7. PMID: 37014396
Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346
Lee JA, Levy DA, Patel KG, Brennan E, Oyer SL
Laryngoscope 2021 Jan;131(1):59-66. Epub 2020 Feb 11 doi: 10.1002/lary.28551. PMID: 32045028

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