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Abnormality of the bed nucleus of stria terminalis

MedGen UID:
896347
Concept ID:
C4280761
Anatomical Abnormality
HPO: HP:0030798

Definition

The stria terminalis is a slender, compact fiber bundle that connects the amygdala (amygdaloid body) with the hypothalamus and other basal forebrain regions. The bed nucleus of the stria terminalis is a limbic forebrain structure that receives heavy projections from, among other areas, the basolateral amygdala, and projects in turn to hypothalamic and brainstem target areas that mediate many of the autonomic and behavioral responses to aversive or threatening stimuli. This term refers to an anomaly of the bed nucleus. [from HPO]

Term Hierarchy

Recent clinical studies

Etiology

van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Houweling AC, Scholman KT, Wakker V, Allaart CP, Uhm JS, Mathijssen IB, Baartscheer T, Postma AV, Barnett P, Verkerk AO, Boukens BJ, Christoffels VM
Circulation 2022 Feb 22;145(8):606-619. Epub 2022 Feb 3 doi: 10.1161/CIRCULATIONAHA.121.054347. PMID: 35113653Free PMC Article
Sun Y, Wang Z, Hu K, Mo Y, Cao P, Hou X, He X, Zhang S, Xue S
Parkinsonism Relat Disord 2021 Sep;90:98-104. Epub 2021 Jul 24 doi: 10.1016/j.parkreldis.2021.07.023. PMID: 34419805
Yang F, Liu Y, Chen S, Dai Z, Yang D, Gao D, Shao J, Wang Y, Wang T, Zhang Z, Zhang L, Lu WW, Li Y, Wang L
J Clin Invest 2020 Dec 1;130(12):6539-6554. doi: 10.1172/JCI136105. PMID: 32910804Free PMC Article
Tolomeo S, Matthews K, Steele D, Baldacchino A
Prog Neuropsychopharmacol Biol Psychiatry 2018 Feb 2;81:333-339. Epub 2017 Sep 14 doi: 10.1016/j.pnpbp.2017.09.007. PMID: 28918267
Brisch R, Bernstein HG, Stauch R, Dobrowolny H, Krell D, Truebner K, Meyer-Lotz G, Bielau H, Steiner J, Kropf S, Gos T, Danos P, Bogerts B
Psychiatry Res 2008 Dec 30;164(3):265-73. doi: 10.1016/j.pscychresns.2007.12.007. PMID: 19022630

Diagnosis

Dhaher R, Bronen RA, Spencer L, Colic L, Brown F, Mian A, Sandhu M, Pittman B, Spencer D, Blumberg HP, Altalib H
Epilepsia 2022 Oct;63(10):2561-2570. Epub 2022 Aug 9 doi: 10.1111/epi.17377. PMID: 35883245
van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Houweling AC, Scholman KT, Wakker V, Allaart CP, Uhm JS, Mathijssen IB, Baartscheer T, Postma AV, Barnett P, Verkerk AO, Boukens BJ, Christoffels VM
Circulation 2022 Feb 22;145(8):606-619. Epub 2022 Feb 3 doi: 10.1161/CIRCULATIONAHA.121.054347. PMID: 35113653Free PMC Article
Sun Y, Wang Z, Hu K, Mo Y, Cao P, Hou X, He X, Zhang S, Xue S
Parkinsonism Relat Disord 2021 Sep;90:98-104. Epub 2021 Jul 24 doi: 10.1016/j.parkreldis.2021.07.023. PMID: 34419805
Cavazos JE, Wang CJ, Sitoh YY, Ng SE, Tien RD
Neuroimaging Clin N Am 1997 Feb;7(1):67-78. PMID: 9100232
Cook EH
Synapse 1990;6(3):292-308. doi: 10.1002/syn.890060309. PMID: 1700486

Therapy

Dhingra S, Mahadik JD, Tarabishy Y, May SB, Vierling JM
Pathology 2022 Oct;54(6):686-693. Epub 2022 May 5 doi: 10.1016/j.pathol.2022.01.009. PMID: 35525796
Leung LS, Ma J
Schizophr Res 2018 Aug;198:36-44. Epub 2017 Aug 8 doi: 10.1016/j.schres.2017.07.053. PMID: 28801194
Gan CL, O'Sullivan MJ, Metzler-Baddeley C, Halpin S
Clin Radiol 2017 Nov;72(11):915-922. Epub 2017 Aug 30 doi: 10.1016/j.crad.2017.04.021. PMID: 28859851Free PMC Article
Grillon C
Psychopharmacology (Berl) 2008 Aug;199(3):421-37. Epub 2007 Dec 6 doi: 10.1007/s00213-007-1019-1. PMID: 18058089Free PMC Article
Cook EH
Synapse 1990;6(3):292-308. doi: 10.1002/syn.890060309. PMID: 1700486

Prognosis

Hu L, Wu K, Li H, Zhu M, Zhang Y, Fu M, Tang M, Lu F, Cai X, An J, Patel N, Lin Y, Zhang Z, Yang M, Mo X
Ital J Pediatr 2024 Sep 19;50(1):189. doi: 10.1186/s13052-024-01764-0. PMID: 39300569Free PMC Article
Fitzsimmons J, Hamoda HM, Swisher T, Terry D, Rosenberger G, Seidman LJ, Goldstein J, Mesholam-Gately R, Petryshen T, Wojcik J, Kikinis R, Kubicki M
Schizophr Res 2014 Jul;156(2-3):157-60. Epub 2014 May 14 doi: 10.1016/j.schres.2014.04.022. PMID: 24837684Free PMC Article
Ressler KJ, Mercer KB, Bradley B, Jovanovic T, Mahan A, Kerley K, Norrholm SD, Kilaru V, Smith AK, Myers AJ, Ramirez M, Engel A, Hammack SE, Toufexis D, Braas KM, Binder EB, May V
Nature 2011 Feb 24;470(7335):492-7. doi: 10.1038/nature09856. PMID: 21350482Free PMC Article
González A, López B, Ravassa S, Querejeta R, Larman M, Díez J, Fortuño MA
Hypertension 2002 Jan;39(1):75-80. doi: 10.1161/hy0102.100788. PMID: 11799082

Clinical prediction guides

Dhingra S, Mahadik JD, Tarabishy Y, May SB, Vierling JM
Pathology 2022 Oct;54(6):686-693. Epub 2022 May 5 doi: 10.1016/j.pathol.2022.01.009. PMID: 35525796
Sun Y, Wang Z, Hu K, Mo Y, Cao P, Hou X, He X, Zhang S, Xue S
Parkinsonism Relat Disord 2021 Sep;90:98-104. Epub 2021 Jul 24 doi: 10.1016/j.parkreldis.2021.07.023. PMID: 34419805
Bayard S, Gosselin N, Robert M, Lassonde M
J Cogn Neurosci 2004 Apr;16(3):401-14. doi: 10.1162/089892904322926746. PMID: 15072676
Kim KJ, Peterson BS
Biol Psychiatry 2003 Jul 1;54(1):76-85. doi: 10.1016/s0006-3223(02)01830-9. PMID: 12842311
Cooper HM, Herbin M, Nevo E
J Comp Neurol 1993 Feb 15;328(3):313-50. doi: 10.1002/cne.903280302. PMID: 8440785

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