Abnormal amplitude of dark-adapted bright flash electroretinogram

MedGen UID:: 892898
•Concept ID:: C4072968
•: Finding

HPO:	HP:0030478

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal amplitude of dark-adapted bright flash electroretinogram

Abnormal eye physiology
- Abnormal visual electrophysiology
  - Abnormal electroretinogram
    - Abnormal full-field electroretinogram
      - Abnormal dark-adapted electroretinogram
        Abnormal dark-adapted bright flash electroretinogram
        Abnormal amplitude of dark-adapted bright flash electroretinogram
        Electronegative electroretinogram
        Reduced amplitude of dark-adapted bright flash electroretinogram a-wave
        Supernormal dark-adapted bright flash electroretinogram b-wave

Recent clinical studies

Etiology

Phenotypic Characteristics of a French Cohort of Patients with X-Linked Retinoschisis.

Orès R, Mohand-Said S, Dhaenens CM, Antonio A, Zeitz C, Augstburger E, Andrieu C, Sahel JA, Audo I
Ophthalmology 2018 Oct;125(10):1587-1596. Epub 2018 May 5 doi: 10.1016/j.ophtha.2018.03.057. PMID: 29739629

The Effect on Retinal Structure and Function of 15 Specific ABCA4 Mutations: A Detailed Examination of 82 Hemizygous Patients.

Fakin A, Robson AG, Chiang JP, Fujinami K, Moore AT, Michaelides M, Holder GE, Webster AR
Invest Ophthalmol Vis Sci 2016 Nov 1;57(14):5963-5973. doi: 10.1167/iovs.16-20446. PMID: 27820952

Retinal effects of 6 months of daily use of tadalafil or sildenafil.

Cordell WH, Maturi RK, Costigan TM, Marmor MF, Weleber RG, Coupland SG, Danis RP, McGettigan JW Jr, Antoszyk AN, Klise S, Sides GD; ERG Testing During Chronic PDE5 Inhibitor Administration (ERG-PDE5i) Consortium
Arch Ophthalmol 2009 Apr;127(4):367-73. doi: 10.1001/archophthalmol.2009.36. PMID: 19365010

Dark adaptation of rod photoreceptors in normal subjects, and in patients with Stargardt disease and an ABCA4 mutation.

Kang Derwent JJ, Derlacki DJ, Hetling JR, Fishman GA, Birch DG, Grover S, Stone EM, Pepperberg DR
Invest Ophthalmol Vis Sci 2004 Jul;45(7):2447-56. doi: 10.1167/iovs.03-1178. PMID: 15223829

RP cone-rod degeneration.

Heckenlively JR
Trans Am Ophthalmol Soc 1987;85:438-70. PMID: 3447340 Free PMC Article

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Diagnosis

Phenotypic Characteristics of a French Cohort of Patients with X-Linked Retinoschisis.

Expanded Retinal Disease Spectrum Associated With Autosomal Recessive Mutations in GUCY2D.

Stunkel ML, Brodie SE, Cideciyan AV, Pfeifer WL, Kennedy EL, Stone EM, Jacobson SG, Drack AV
Am J Ophthalmol 2018 Jun;190:58-68. Epub 2018 Mar 17 doi: 10.1016/j.ajo.2018.03.021. PMID: 29559409

Rod and cone function in the Nougaret form of stationary night blindness.

Sandberg MA, Pawlyk BS, Dan J, Arnaud B, Dryja TP, Berson EL
Arch Ophthalmol 1998 Jul;116(7):867-72. doi: 10.1001/archopht.116.7.867. PMID: 9682699

The electroretinographic diagnosis of the incomplete form of congenital stationary night blindness.

Tremblay F, Laroche RG, De Becker I
Vision Res 1995 Aug;35(16):2383-93. doi: 10.1016/0042-6989(95)00006-l. PMID: 7571473

See all (4)

Therapy

Retinal effects of 6 months of daily use of tadalafil or sildenafil.

See all (1)

Prognosis

Macular maldevelopment in ATF6-mediated retinal dysfunction.

Ritter M, Arno G, Ba-Abbad R, Holder GE, Webster AR
Ophthalmic Genet 2019 Dec;40(6):564-569. Epub 2020 Jan 3 doi: 10.1080/13816810.2019.1706749. PMID: 31900015

Phenotypic Characteristics of a French Cohort of Patients with X-Linked Retinoschisis.

See all (2)