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Increased circulating androgen concentration

MedGen UID:
892873
•Concept ID:
C4072893
•
Finding
Synonyms: Hyperandrogenemia; Increased circulating androgen level
 
HPO: HP:0030348

Definition

An elevation of the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating androgen concentration

Professional guidelines

PubMed

Circulating GDF15 concentrations in girls with low birth weight: effects of prolonged metformin treatment.
Díaz M, Carreras-Badosa G, Villarroya J, Gavaldà-Navarro A, Bassols J, de Zegher F, López-Bermejo A, Villarroya F, Ibáñez L
Pediatr Res 2023 Mar;93(4):964-968. Epub 2022 Jul 11 doi: 10.1038/s41390-022-02175-9. PMID: 35817957
Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment.
Bourebaba N, Ngo T, Śmieszek A, Bourebaba L, Marycz K
Biomed Pharmacother 2022 Sep;153:113261. Epub 2022 Jun 20 doi: 10.1016/j.biopha.2022.113261. PMID: 35738176
Osteoporosis in men. New insights into aetiology, pathogenesis, prevention and management.
Ebeling PR
Drugs Aging 1998 Dec;13(6):421-34. doi: 10.2165/00002512-199813060-00002. PMID: 9883398

Recent clinical studies

Etiology

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Androgens, aging, and prostate health.
Welén K, Damber JE
Rev Endocr Metab Disord 2022 Dec;23(6):1221-1231. Epub 2022 Jun 24 doi: 10.1007/s11154-022-09730-z. PMID: 35748976Free PMC Article
Perfluoroalkyl substances and sex hormones in postmenopausal women: NHANES 2013-2016.
Wang Y, Aimuzi R, Nian M, Zhang Y, Luo K, Zhang J
Environ Int 2021 Apr;149:106408. Epub 2021 Feb 3 doi: 10.1016/j.envint.2021.106408. PMID: 33548847
Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.
Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA
Endocr Rev 2017 Jun 1;38(3):220-254. doi: 10.1210/er.2016-1067. PMID: 28472278Free PMC Article
Testosterone dose-response relationships in healthy young men.
Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW
Am J Physiol Endocrinol Metab 2001 Dec;281(6):E1172-81. doi: 10.1152/ajpendo.2001.281.6.E1172. PMID: 11701431

Diagnosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Androgens in Menopausal Women: Not Only Polycystic Ovary Syndrome.
Kostakis EK, Gkioni LN, Macut D, Mastorakos G
Front Horm Res 2019;53:135-161. Epub 2019 Sep 9 doi: 10.1159/000494909. PMID: 31499509
Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.
Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA
Endocr Rev 2017 Jun 1;38(3):220-254. doi: 10.1210/er.2016-1067. PMID: 28472278Free PMC Article
Premature adrenarche--a common condition with variable presentation.
Utriainen P, Laakso S, Liimatta J, Jääskeläinen J, Voutilainen R
Horm Res Paediatr 2015;83(4):221-31. Epub 2015 Feb 7 doi: 10.1159/000369458. PMID: 25676474
Premature adrenarche: etiology, clinical findings, and consequences.
Voutilainen R, Jääskeläinen J
J Steroid Biochem Mol Biol 2015 Jan;145:226-36. Epub 2014 Jun 9 doi: 10.1016/j.jsbmb.2014.06.004. PMID: 24923732

Therapy

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Androgens, aging, and prostate health.
Welén K, Damber JE
Rev Endocr Metab Disord 2022 Dec;23(6):1221-1231. Epub 2022 Jun 24 doi: 10.1007/s11154-022-09730-z. PMID: 35748976Free PMC Article
Why is understanding the relationship of testosterone to cardiovascular risk so important?
Yeap BB, Anawalt BD
Asian J Androl 2018 Mar-Apr;20(2):107-108. doi: 10.4103/aja.aja_71_17. PMID: 29405170Free PMC Article
Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players.
van der Merwe J, Brooks NE, Myburgh KH
Clin J Sport Med 2009 Sep;19(5):399-404. doi: 10.1097/JSM.0b013e3181b8b52f. PMID: 19741313
Testosterone dose-response relationships in healthy young men.
Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW
Am J Physiol Endocrinol Metab 2001 Dec;281(6):E1172-81. doi: 10.1152/ajpendo.2001.281.6.E1172. PMID: 11701431

Prognosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies.
Mustieles V, Balogh RK, Axelstad M, Montazeri P, Márquez S, Vrijheid M, Draskau MK, Taxvig C, Peinado FM, Berman T, Frederiksen H, Fernández MF, Marie Vinggaard A, Andersson AM
Environ Int 2023 Mar;173:107739. Epub 2023 Jan 6 doi: 10.1016/j.envint.2023.107739. PMID: 36805158
Hypogonadism and male obesity: Focus on unresolved questions.
Grossmann M
Clin Endocrinol (Oxf) 2018 Jul;89(1):11-21. Epub 2018 May 16 doi: 10.1111/cen.13723. PMID: 29683196
Estrogen and bone health in men and women.
Cauley JA
Steroids 2015 Jul;99(Pt A):11-5. Epub 2014 Dec 30 doi: 10.1016/j.steroids.2014.12.010. PMID: 25555470
Pancreas: a sex steroid-dependent tissue.
Robles-Diaz G, Duarte-Rojo A
Isr Med Assoc J 2001 May;3(5):364-8. PMID: 11411203

Clinical prediction guides

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.
Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA
Endocr Rev 2017 Jun 1;38(3):220-254. doi: 10.1210/er.2016-1067. PMID: 28472278Free PMC Article
Gonadal steroids and humoral immunity.
Sakiani S, Olsen NJ, Kovacs WJ
Nat Rev Endocrinol 2013 Jan;9(1):56-62. Epub 2012 Nov 27 doi: 10.1038/nrendo.2012.206. PMID: 23183675
Effect of vitamin D supplementation on testosterone levels in men.
Pilz S, Frisch S, Koertke H, Kuhn J, Dreier J, Obermayer-Pietsch B, Wehr E, Zittermann A
Horm Metab Res 2011 Mar;43(3):223-5. Epub 2010 Dec 10 doi: 10.1055/s-0030-1269854. PMID: 21154195
Testosterone physiology in resistance exercise and training: the up-stream regulatory elements.
Vingren JL, Kraemer WJ, Ratamess NA, Anderson JM, Volek JS, Maresh CM
Sports Med 2010 Dec 1;40(12):1037-53. doi: 10.2165/11536910-000000000-00000. PMID: 21058750
Testosterone and atherosclerosis.
Eckardstein Av, Wu FC
Growth Horm IGF Res 2003 Aug;13 Suppl A:S72-84. doi: 10.1016/s1096-6374(03)00059-5. PMID: 12914731

Recent systematic reviews

Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-analyses.
Yeap BB, Marriott RJ, Dwivedi G, Adams RJ, Antonio L, Ballantyne CM, Bauer DC, Bhasin S, Biggs ML, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Handelsman DJ, Hankey GJ, Hannemann A, Haring R, Hsu B, Martin SA, Matsumoto AM, Mellström D, Ohlsson C, O'Neill TW, Orwoll ES, Quartagno M, Shores MM, Steveling A, Tivesten Å, Travison TG, Vanderschueren D, Wittert GA, Wu FCW, Murray K
Ann Intern Med 2024 Jun;177(6):768-781. Epub 2024 May 14 doi: 10.7326/M23-2781. PMID: 38739921
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Prevalence of 'obesity-associated gonadal dysfunction' in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis.
Escobar-Morreale HF, Santacruz E, Luque-Ramírez M, Botella Carretero JI
Hum Reprod Update 2017 Jul 1;23(4):390-408. doi: 10.1093/humupd/dmx012. PMID: 28486593
Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials.
Ennour-Idrissi K, Maunsell E, Diorio C
Breast Cancer Res 2015 Nov 5;17(1):139. doi: 10.1186/s13058-015-0647-3. PMID: 26541144Free PMC Article
The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis.
Zimmerman Y, Eijkemans MJ, Coelingh Bennink HJ, Blankenstein MA, Fauser BC
Hum Reprod Update 2014 Jan-Feb;20(1):76-105. Epub 2013 Sep 29 doi: 10.1093/humupd/dmt038. PMID: 24082040Free PMC Article

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