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Decreased CSF neopterin level

MedGen UID:
892759
•Concept ID:
C4073153
•
Finding
HPO: HP:0040205

Definition

Decreased concentration of neopterin in the cerebrospinal fluid (CSF). [from HPO]

Professional guidelines

PubMed

The efficacy of haemoperfusion combined with continuous venovenous haemodiafiltration in the treatment of severe viral encephalitis in children.
Zhao JL, Wang ZY, Li SJ, Ma HK, Liu X, Zhan XW, Niu WW, Shen P
Ital J Pediatr 2023 Feb 15;49(1):21. doi: 10.1186/s13052-023-01411-0. PMID: 36793135Free PMC Article
Antiretroviral treatment reduces increased CSF neurofilament protein (NFL) in HIV-1 infection.
Mellgren A, Price RW, Hagberg L, Rosengren L, Brew BJ, Gisslén M
Neurology 2007 Oct 9;69(15):1536-41. doi: 10.1212/01.wnl.0000277635.05973.55. PMID: 17923616
Clinical and immunologic follow-up study of patients with neurocysticercosis after treatment with praziquantel.
Rolfs A, Mühlschlegel F, Jansen-Rosseck R, Martins AR, Bedaque EA, Tamburus WM, Pedretti L, Schulte G, Feldmeier H, Kremsner P
Neurology 1995 Mar;45(3 Pt 1):532-8. doi: 10.1212/wnl.45.3.532. PMID: 7898711

Recent clinical studies

Etiology

Long-term safety and efficacy of mogamulizumab (anti-CCR4) for treating virus-associated myelopathy.
Sato T, Yamauchi J, Yagishita N, Araya N, Takao N, Ohta Y, Inoue E, Takahashi M, Yamagishi M, Suzuki Y, Uchimaru K, Matsumoto N, Hasegawa Y, Yamano Y
Brain 2023 Aug 1;146(8):3181-3191. doi: 10.1093/brain/awad139. PMID: 37093965
The efficacy of haemoperfusion combined with continuous venovenous haemodiafiltration in the treatment of severe viral encephalitis in children.
Zhao JL, Wang ZY, Li SJ, Ma HK, Liu X, Zhan XW, Niu WW, Shen P
Ital J Pediatr 2023 Feb 15;49(1):21. doi: 10.1186/s13052-023-01411-0. PMID: 36793135Free PMC Article
Central kynurenine pathway shift with age in women.
de Bie J, Guest J, Guillemin GJ, Grant R
J Neurochem 2016 Mar;136(5):995-1003. Epub 2016 Jan 20 doi: 10.1111/jnc.13496. PMID: 26670548
CXCL13 and neopterin concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other diseases that cause neuroinflammation.
Hytönen J, Kortela E, Waris M, Puustinen J, Salo J, Oksi J
J Neuroinflammation 2014 Jun 11;11:103. doi: 10.1186/1742-2094-11-103. PMID: 24920219Free PMC Article
CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.
Brew BJ, Pemberton L, Blennow K, Wallin A, Hagberg L
Neurology 2005 Nov 8;65(9):1490-2. doi: 10.1212/01.wnl.0000183293.95787.b7. PMID: 16275845

Diagnosis

Three cases of rheumatoid meningitis with elevated CSF neopterin levels.
Miyaue N, Yabe H, Yamanishi Y, Tada S, Ando R, Nagai M
J Neuroimmunol 2020 Nov 15;348:577396. Epub 2020 Sep 16 doi: 10.1016/j.jneuroim.2020.577396. PMID: 32971299
CXCL13 and neopterin concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other diseases that cause neuroinflammation.
Hytönen J, Kortela E, Waris M, Puustinen J, Salo J, Oksi J
J Neuroinflammation 2014 Jun 11;11:103. doi: 10.1186/1742-2094-11-103. PMID: 24920219Free PMC Article
Biomarker evidence of axonal injury in neuroasymptomatic HIV-1 patients.
Jessen Krut J, Mellberg T, Price RW, Hagberg L, Fuchs D, Rosengren L, Nilsson S, Zetterberg H, Gisslén M
PLoS One 2014;9(2):e88591. Epub 2014 Feb 11 doi: 10.1371/journal.pone.0088591. PMID: 24523921Free PMC Article
Persistent intrathecal immune activation in HIV-1-infected individuals on antiretroviral therapy.
Yilmaz A, Price RW, Spudich S, Fuchs D, Hagberg L, Gisslén M
J Acquir Immune Defic Syndr 2008 Feb 1;47(2):168-73. doi: 10.1097/QAI.0b013e31815ace97. PMID: 17971711Free PMC Article
CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.
Brew BJ, Pemberton L, Blennow K, Wallin A, Hagberg L
Neurology 2005 Nov 8;65(9):1490-2. doi: 10.1212/01.wnl.0000183293.95787.b7. PMID: 16275845

Therapy

Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy.
Sato T, Nagai M, Watanabe O, Misu T, Takenouchi N, Ohkubo R, Ishihara S, Tsuboi Y, Katsuno M, Nakagawa M, Matsushita T, Aso Y, Matsuura E, Tokashiki T, Mukaino A, Adachi H, Nakanishi K, Yamaguchi Y, Yamaguchi S, Yamano Y
J Neurol 2024 Jun;271(6):3471-3485. Epub 2024 Mar 2 doi: 10.1007/s00415-024-12239-x. PMID: 38430272Free PMC Article
Long-term safety and efficacy of mogamulizumab (anti-CCR4) for treating virus-associated myelopathy.
Sato T, Yamauchi J, Yagishita N, Araya N, Takao N, Ohta Y, Inoue E, Takahashi M, Yamagishi M, Suzuki Y, Uchimaru K, Matsumoto N, Hasegawa Y, Yamano Y
Brain 2023 Aug 1;146(8):3181-3191. doi: 10.1093/brain/awad139. PMID: 37093965
Intrathecal dexamethasone therapy for febrile infection-related epilepsy syndrome.
Horino A, Kuki I, Inoue T, Nukui M, Okazaki S, Kawawaki H, Togawa M, Amo K, Ishikawa J, Ujiro A, Shiomi M, Sakuma H
Ann Clin Transl Neurol 2021 Mar;8(3):645-655. Epub 2021 Feb 5 doi: 10.1002/acn3.51308. PMID: 33547757Free PMC Article
Biological Effects of Anti-Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Antibody Formation in Patients Treated With GM-CSF (Sargramostim) as Adjuvant Therapy of Melanoma.
Spitler LE, Cao H, Piironen T, Whiteside TL, Weber RW, Cruickshank S
Am J Clin Oncol 2017 Apr;40(2):207-213. doi: 10.1097/COC.0000000000000124. PMID: 25286079Free PMC Article
CXCL13 and neopterin concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other diseases that cause neuroinflammation.
Hytönen J, Kortela E, Waris M, Puustinen J, Salo J, Oksi J
J Neuroinflammation 2014 Jun 11;11:103. doi: 10.1186/1742-2094-11-103. PMID: 24920219Free PMC Article

Prognosis

Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy.
Sato T, Nagai M, Watanabe O, Misu T, Takenouchi N, Ohkubo R, Ishihara S, Tsuboi Y, Katsuno M, Nakagawa M, Matsushita T, Aso Y, Matsuura E, Tokashiki T, Mukaino A, Adachi H, Nakanishi K, Yamaguchi Y, Yamaguchi S, Yamano Y
J Neurol 2024 Jun;271(6):3471-3485. Epub 2024 Mar 2 doi: 10.1007/s00415-024-12239-x. PMID: 38430272Free PMC Article
The efficacy of haemoperfusion combined with continuous venovenous haemodiafiltration in the treatment of severe viral encephalitis in children.
Zhao JL, Wang ZY, Li SJ, Ma HK, Liu X, Zhan XW, Niu WW, Shen P
Ital J Pediatr 2023 Feb 15;49(1):21. doi: 10.1186/s13052-023-01411-0. PMID: 36793135Free PMC Article
Intrathecal dexamethasone therapy for febrile infection-related epilepsy syndrome.
Horino A, Kuki I, Inoue T, Nukui M, Okazaki S, Kawawaki H, Togawa M, Amo K, Ishikawa J, Ujiro A, Shiomi M, Sakuma H
Ann Clin Transl Neurol 2021 Mar;8(3):645-655. Epub 2021 Feb 5 doi: 10.1002/acn3.51308. PMID: 33547757Free PMC Article
CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.
Brew BJ, Pemberton L, Blennow K, Wallin A, Hagberg L
Neurology 2005 Nov 8;65(9):1490-2. doi: 10.1212/01.wnl.0000183293.95787.b7. PMID: 16275845
Significance of CSF total neopterin and biopterin in inflammatory neurological diseases.
Furukawa Y, Nishi K, Kondo T, Tanabe K, Mizuno Y
J Neurol Sci 1992 Aug;111(1):65-72. doi: 10.1016/0022-510x(92)90113-y. PMID: 1402999

Clinical prediction guides

Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy.
Sato T, Nagai M, Watanabe O, Misu T, Takenouchi N, Ohkubo R, Ishihara S, Tsuboi Y, Katsuno M, Nakagawa M, Matsushita T, Aso Y, Matsuura E, Tokashiki T, Mukaino A, Adachi H, Nakanishi K, Yamaguchi Y, Yamaguchi S, Yamano Y
J Neurol 2024 Jun;271(6):3471-3485. Epub 2024 Mar 2 doi: 10.1007/s00415-024-12239-x. PMID: 38430272Free PMC Article
Long-term safety and efficacy of mogamulizumab (anti-CCR4) for treating virus-associated myelopathy.
Sato T, Yamauchi J, Yagishita N, Araya N, Takao N, Ohta Y, Inoue E, Takahashi M, Yamagishi M, Suzuki Y, Uchimaru K, Matsumoto N, Hasegawa Y, Yamano Y
Brain 2023 Aug 1;146(8):3181-3191. doi: 10.1093/brain/awad139. PMID: 37093965
CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.
Brew BJ, Pemberton L, Blennow K, Wallin A, Hagberg L
Neurology 2005 Nov 8;65(9):1490-2. doi: 10.1212/01.wnl.0000183293.95787.b7. PMID: 16275845
Significance of CSF total neopterin and biopterin in inflammatory neurological diseases.
Furukawa Y, Nishi K, Kondo T, Tanabe K, Mizuno Y
J Neurol Sci 1992 Aug;111(1):65-72. doi: 10.1016/0022-510x(92)90113-y. PMID: 1402999
Neonatal hyperphenylalaninaemia presumably caused by a new variant of biopterin synthetase deficiency.
Dhondt JL, Guibaud P, Rolland MO, Dorche C, Andre S, Forzy G, Hayte JM
Eur J Pediatr 1988 Feb;147(2):153-7. doi: 10.1007/BF00442213. PMID: 3366132

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