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Fusion-Negative Alveolar Rhabdomyosarcoma

MedGen UID:
891539
•Concept ID:
C4054914
•
Neoplastic Process

Definition

An alveolar rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFusion-Negative Alveolar Rhabdomyosarcoma

Professional guidelines

PubMed

Significance of fusion status, Oberlin risk factors, local and maintenance treatment in pediatric and adolescent patients with metastatic rhabdomyosarcoma: Data of the European Soft Tissue Sarcoma Registry SoTiSaR.
Heinz AT, Schönstein A, Ebinger M, Fuchs J, Timmermann B, Seitz G, Vokuhl C, Münter M, Pajtler KW, Stegmaier S, von Kalle T, Kratz CP, Ljungman G, Juntti H, Klingebiel T, Koscielniak E, Sparber-Sauer M; Cooperative Weichteilsarkom Studiengruppe
Pediatr Blood Cancer 2024 Jan;71(1):e30707. Epub 2023 Oct 9 doi: 10.1002/pbc.30707. PMID: 37814424

Recent clinical studies

Therapy

Refractory alveolar rhabdomyosarcoma in an 11-year-old male.
Ricker CA, Woods AD, Simonson W, Lathara M, Srinivasa G, Rudzinski ER, Mansoor A, Irwin RG, Keller C, Berlow NE
Cold Spring Harb Mol Case Stud 2021 Feb;7(1) Epub 2021 Feb 19 doi: 10.1101/mcs.a005983. PMID: 33436392Free PMC Article

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