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Nephropathy due to Ciclosporin

MedGen UID:
890603
•Concept ID:
C4054404
•
Disease or Syndrome

Definition

Kidney damage resulting from ciclosporin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephropathy due to Ciclosporin

Professional guidelines

PubMed

Membranous nephropathy treatment standard.
Radhakrishnan Y, Zand L, Sethi S, Fervenza FC
Nephrol Dial Transplant 2024 Feb 28;39(3):403-413. doi: 10.1093/ndt/gfad225. PMID: 37934599
EULAR recommendations for the management of systemic lupus erythematosus: 2023 update.
Fanouriakis A, Kostopoulou M, Andersen J, Aringer M, Arnaud L, Bae SC, Boletis J, Bruce IN, Cervera R, Doria A, Dörner T, Furie RA, Gladman DD, Houssiau FA, Inês LS, Jayne D, Kouloumas M, Kovács L, Mok CC, Morand EF, Moroni G, Mosca M, Mucke J, Mukhtyar CB, Nagy G, Navarra S, Parodis I, Pego-Reigosa JM, Petri M, Pons-Estel BA, Schneider M, Smolen JS, Svenungsson E, Tanaka Y, Tektonidou MG, Teng YO, Tincani A, Vital EM, van Vollenhoven RF, Wincup C, Bertsias G, Boumpas DT
Ann Rheum Dis 2024 Jan 2;83(1):15-29. doi: 10.1136/ard-2023-224762. PMID: 37827694
Safety and Efficacy of Long-Term Voclosporin Treatment for Lupus Nephritis in the Phase 3 AURORA 2 Clinical Trial.
Saxena A, Ginzler EM, Gibson K, Satirapoj B, Santillán AEZ, Levchenko O, Navarra S, Atsumi T, Yasuda S, Chavez-Perez NN, Arriens C, Parikh SV, Caster DJ, Birardi V, Randhawa S, Lisk L, Huizinga RB, Teng YKO
Arthritis Rheumatol 2024 Jan;76(1):59-67. Epub 2023 Sep 15 doi: 10.1002/art.42657. PMID: 37466424

Recent clinical studies

Etiology

Safety and Efficacy of Long-Term Voclosporin Treatment for Lupus Nephritis in the Phase 3 AURORA 2 Clinical Trial.
Saxena A, Ginzler EM, Gibson K, Satirapoj B, Santillán AEZ, Levchenko O, Navarra S, Atsumi T, Yasuda S, Chavez-Perez NN, Arriens C, Parikh SV, Caster DJ, Birardi V, Randhawa S, Lisk L, Huizinga RB, Teng YKO
Arthritis Rheumatol 2024 Jan;76(1):59-67. Epub 2023 Sep 15 doi: 10.1002/art.42657. PMID: 37466424
Anti-PLA2R Antibody Levels and Clinical Risk Factors for Treatment Nonresponse in Membranous Nephropathy.
Barbour SJ, Fervenza FC, Induruwage D, Brenchley PE, Rovin B, Hladunewich MA, Reich HN, Lafayette R, Aslam N, Appel GB, Zand L, Kiryluk K, Liu L, Cattran DC; MENTOR Trial Investigators
Clin J Am Soc Nephrol 2023 Oct 1;18(10):1283-1293. Epub 2023 Jul 20 doi: 10.2215/CJN.0000000000000237. PMID: 37471101Free PMC Article
Interventions for focal segmental glomerulosclerosis in adults.
Hodson EM, Sinha A, Cooper TE
Cochrane Database Syst Rev 2022 Feb 28;2(2):CD003233. doi: 10.1002/14651858.CD003233.pub3. PMID: 35224732Free PMC Article
Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome.
von Groote TC, Williams G, Au EH, Chen Y, Mathew AT, Hodson EM, Tunnicliffe DJ
Cochrane Database Syst Rev 2021 Nov 15;11(11):CD004293. doi: 10.1002/14651858.CD004293.pub4. PMID: 34778952Free PMC Article
Calcineurin inhibitor nephrotoxicity.
Naesens M, Kuypers DR, Sarwal M
Clin J Am Soc Nephrol 2009 Feb;4(2):481-508. doi: 10.2215/CJN.04800908. PMID: 19218475

Diagnosis

Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.
Rovin BH, Teng YKO, Ginzler EM, Arriens C, Caster DJ, Romero-Diaz J, Gibson K, Kaplan J, Lisk L, Navarra S, Parikh SV, Randhawa S, Solomons N, Huizinga RB
Lancet 2021 May 29;397(10289):2070-2080. Epub 2021 May 7 doi: 10.1016/S0140-6736(21)00578-X. PMID: 33971155
Calcineurin inhibitors in lupus nephritis.
Ponticelli C, Podestà MA
J Nephrol 2021 Apr;34(2):399-402. doi: 10.1007/s40620-020-00757-6. PMID: 32462477
Ciclosporin use during pregnancy.
Paziana K, Del Monaco M, Cardonick E, Moritz M, Keller M, Smith B, Coscia L, Armenti V
Drug Saf 2013 May;36(5):279-94. doi: 10.1007/s40264-013-0034-x. PMID: 23516008
Calcineurin inhibitor nephrotoxicity.
Naesens M, Kuypers DR, Sarwal M
Clin J Am Soc Nephrol 2009 Feb;4(2):481-508. doi: 10.2215/CJN.04800908. PMID: 19218475
Nephrotic syndrome in childhood.
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064

Therapy

Voclosporin: Unique Chemistry, Pharmacology and Toxicity Profile, and Possible Options for Implementation into the Management of Lupus Nephritis.
Kale A, Shelke V, Lei Y, Gaikwad AB, Anders HJ
Cells 2023 Oct 11;12(20) doi: 10.3390/cells12202440. PMID: 37887284Free PMC Article
Interventions for focal segmental glomerulosclerosis in adults.
Hodson EM, Sinha A, Cooper TE
Cochrane Database Syst Rev 2022 Feb 28;2(2):CD003233. doi: 10.1002/14651858.CD003233.pub3. PMID: 35224732Free PMC Article
Calcineurin inhibitor nephrotoxicity.
Naesens M, Kuypers DR, Sarwal M
Clin J Am Soc Nephrol 2009 Feb;4(2):481-508. doi: 10.2215/CJN.04800908. PMID: 19218475
Nephrotic syndrome in childhood.
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064
Cyclosporin clinical pharmacokinetics.
Fahr A
Clin Pharmacokinet 1993 Jun;24(6):472-95. doi: 10.2165/00003088-199324060-00004. PMID: 8513650

Prognosis

Anti-PLA2R Antibody Levels and Clinical Risk Factors for Treatment Nonresponse in Membranous Nephropathy.
Barbour SJ, Fervenza FC, Induruwage D, Brenchley PE, Rovin B, Hladunewich MA, Reich HN, Lafayette R, Aslam N, Appel GB, Zand L, Kiryluk K, Liu L, Cattran DC; MENTOR Trial Investigators
Clin J Am Soc Nephrol 2023 Oct 1;18(10):1283-1293. Epub 2023 Jul 20 doi: 10.2215/CJN.0000000000000237. PMID: 37471101Free PMC Article
Belatacept and Long-Term Outcomes in Kidney Transplantation.
Vincenti F, Rostaing L, Grinyo J, Rice K, Steinberg S, Gaite L, Moal MC, Mondragon-Ramirez GA, Kothari J, Polinsky MS, Meier-Kriesche HU, Munier S, Larsen CP
N Engl J Med 2016 Jan 28;374(4):333-43. doi: 10.1056/NEJMoa1506027. PMID: 26816011
Immunotherapy in renal diseases.
Kher A, Kher V
Med Clin North Am 2012 May;96(3):545-64, x. Epub 2012 May 22 doi: 10.1016/j.mcna.2012.04.007. PMID: 22703855
Nephrotic syndrome in childhood.
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064
Cyclosporine.
Ptachcinski RJ, Burckart GJ, Venkataramanan R
Drug Intell Clin Pharm 1985 Feb;19(2):90-100. doi: 10.1177/106002808501900202. PMID: 3882378

Clinical prediction guides

Anti-PLA2R Antibody Levels and Clinical Risk Factors for Treatment Nonresponse in Membranous Nephropathy.
Barbour SJ, Fervenza FC, Induruwage D, Brenchley PE, Rovin B, Hladunewich MA, Reich HN, Lafayette R, Aslam N, Appel GB, Zand L, Kiryluk K, Liu L, Cattran DC; MENTOR Trial Investigators
Clin J Am Soc Nephrol 2023 Oct 1;18(10):1283-1293. Epub 2023 Jul 20 doi: 10.2215/CJN.0000000000000237. PMID: 37471101Free PMC Article
Efficacy of low or heavy rituximab‑based protocols and comparison with seven regimens in idiopathic membranous nephropathy: a systematic review and network meta-analysis.
Chen M, Zhang X, Xiong Y, Xu G
Int Urol Nephrol 2023 Mar;55(3):641-651. Epub 2022 Sep 25 doi: 10.1007/s11255-022-03372-5. PMID: 36161550
The evolution of the therapeutic approach to membranous nephropathy.
Ponticelli C, Patrizia P, Del Vecchio L, Locatelli F
Nephrol Dial Transplant 2021 Apr 26;36(5):768-773. doi: 10.1093/ndt/gfaa014. PMID: 32206786
Belatacept and Long-Term Outcomes in Kidney Transplantation.
Vincenti F, Rostaing L, Grinyo J, Rice K, Steinberg S, Gaite L, Moal MC, Mondragon-Ramirez GA, Kothari J, Polinsky MS, Meier-Kriesche HU, Munier S, Larsen CP
N Engl J Med 2016 Jan 28;374(4):333-43. doi: 10.1056/NEJMoa1506027. PMID: 26816011
Treatment of childhood nephrotic syndrome.
Mendoza SA, Tune BM
J Am Soc Nephrol 1992 Oct;3(4):889-94. doi: 10.1681/ASN.V34889. PMID: 1450365

Recent systematic reviews

Interventions for preventing and treating kidney disease in IgA vasculitis.
Hahn D, Hodson EM, Craig JC
Cochrane Database Syst Rev 2023 Feb 28;2(2):CD005128. doi: 10.1002/14651858.CD005128.pub4. PMID: 36853224Free PMC Article
Interventions for minimal change disease in adults with nephrotic syndrome.
Azukaitis K, Palmer SC, Strippoli GF, Hodson EM
Cochrane Database Syst Rev 2022 Mar 1;3(3):CD001537. doi: 10.1002/14651858.CD001537.pub5. PMID: 35230699Free PMC Article
Interventions for focal segmental glomerulosclerosis in adults.
Hodson EM, Sinha A, Cooper TE
Cochrane Database Syst Rev 2022 Feb 28;2(2):CD003233. doi: 10.1002/14651858.CD003233.pub3. PMID: 35224732Free PMC Article
Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome.
von Groote TC, Williams G, Au EH, Chen Y, Mathew AT, Hodson EM, Tunnicliffe DJ
Cochrane Database Syst Rev 2021 Nov 15;11(11):CD004293. doi: 10.1002/14651858.CD004293.pub4. PMID: 34778952Free PMC Article
Drug-induced thrombotic microangiopathy: a systematic review of published reports.
Al-Nouri ZL, Reese JA, Terrell DR, Vesely SK, George JN
Blood 2015 Jan 22;125(4):616-8. Epub 2014 Nov 20 doi: 10.1182/blood-2014-11-611335. PMID: 25414441Free PMC Article

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