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Infant Acute Lymphoblastic Leukemia with MLL Rearrangement

MedGen UID:
890208
Concept ID:
C4054729
Neoplastic Process

Definition

An acute lymphoblastic leukemia with rearrangement of the MLL (KMT2A) gene that occurs in infancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant Acute Lymphoblastic Leukemia with MLL Rearrangement

Professional guidelines

PubMed

Tomizawa D
Pediatr Int 2015 Oct;57(5):811-9. doi: 10.1111/ped.12758. PMID: 26215843
Marschalek R
Arch Pharm (Weinheim) 2015 Apr;348(4):221-8. Epub 2015 Mar 4 doi: 10.1002/ardp.201400449. PMID: 25740345
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298

Recent clinical studies

Etiology

El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Meyer C, Burmeister T, Gröger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, Barbieri Blunck C, Almeida Lopes B, Zuna J, Trka J, Ballerini P, Lapillonne H, De Braekeleer M, Cazzaniga G, Corral Abascal L, van der Velden VHJ, Delabesse E, Park TS, Oh SH, Silva MLM, Lund-Aho T, Juvonen V, Moore AS, Heidenreich O, Vormoor J, Zerkalenkova E, Olshanskaya Y, Bueno C, Menendez P, Teigler-Schlegel A, Zur Stadt U, Lentes J, Göhring G, Kustanovich A, Aleinikova O, Schäfer BW, Kubetzko S, Madsen HO, Gruhn B, Duarte X, Gameiro P, Lippert E, Bidet A, Cayuela JM, Clappier E, Alonso CN, Zwaan CM, van den Heuvel-Eibrink MM, Izraeli S, Trakhtenbrot L, Archer P, Hancock J, Möricke A, Alten J, Schrappe M, Stanulla M, Strehl S, Attarbaschi A, Dworzak M, Haas OA, Panzer-Grümayer R, Sedék L, Szczepański T, Caye A, Suarez L, Cavé H, Marschalek R
Leukemia 2018 Feb;32(2):273-284. Epub 2017 Jul 13 doi: 10.1038/leu.2017.213. PMID: 28701730Free PMC Article
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article
Marschalek R
Arch Pharm (Weinheim) 2015 Apr;348(4):221-8. Epub 2015 Mar 4 doi: 10.1002/ardp.201400449. PMID: 25740345

Diagnosis

El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Carroll WL, Bhojwani D, Min DJ, Raetz E, Relling M, Davies S, Downing JR, Willman CL, Reed JC
Hematology Am Soc Hematol Educ Program 2003:102-31. doi: 10.1182/asheducation-2003.1.102. PMID: 14633779

Therapy

Tomizawa D, Miyamura T, Koh K, Ishii E
Pediatr Int 2022 Jan;64(1):e14935. doi: 10.1111/ped.14935. PMID: 34324764
El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777
Marschalek R
Arch Pharm (Weinheim) 2015 Apr;348(4):221-8. Epub 2015 Mar 4 doi: 10.1002/ardp.201400449. PMID: 25740345

Prognosis

El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Britten O, Ragusa D, Tosi S, Kamel YM
Cells 2019 Oct 29;8(11) doi: 10.3390/cells8111341. PMID: 31671855Free PMC Article
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article

Clinical prediction guides

Meyer C, Burmeister T, Gröger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, Barbieri Blunck C, Almeida Lopes B, Zuna J, Trka J, Ballerini P, Lapillonne H, De Braekeleer M, Cazzaniga G, Corral Abascal L, van der Velden VHJ, Delabesse E, Park TS, Oh SH, Silva MLM, Lund-Aho T, Juvonen V, Moore AS, Heidenreich O, Vormoor J, Zerkalenkova E, Olshanskaya Y, Bueno C, Menendez P, Teigler-Schlegel A, Zur Stadt U, Lentes J, Göhring G, Kustanovich A, Aleinikova O, Schäfer BW, Kubetzko S, Madsen HO, Gruhn B, Duarte X, Gameiro P, Lippert E, Bidet A, Cayuela JM, Clappier E, Alonso CN, Zwaan CM, van den Heuvel-Eibrink MM, Izraeli S, Trakhtenbrot L, Archer P, Hancock J, Möricke A, Alten J, Schrappe M, Stanulla M, Strehl S, Attarbaschi A, Dworzak M, Haas OA, Panzer-Grümayer R, Sedék L, Szczepański T, Caye A, Suarez L, Cavé H, Marschalek R
Leukemia 2018 Feb;32(2):273-284. Epub 2017 Jul 13 doi: 10.1038/leu.2017.213. PMID: 28701730Free PMC Article
Mansur MB, Ford AM, Emerenciano M
Biochim Biophys Acta Rev Cancer 2017 Dec;1868(2):521-526. Epub 2017 Oct 19 doi: 10.1016/j.bbcan.2017.10.005. PMID: 29056538
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article
Carroll WL, Bhojwani D, Min DJ, Raetz E, Relling M, Davies S, Downing JR, Willman CL, Reed JC
Hematology Am Soc Hematol Educ Program 2003:102-31. doi: 10.1182/asheducation-2003.1.102. PMID: 14633779

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