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IgM - Associated Nephropathy

MedGen UID:
889797
•Concept ID:
C4054743
•
Disease or Syndrome

Definition

A condition characterized by deposition of IgM antibody in the glomerulus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIgM - Associated Nephropathy

Professional guidelines

PubMed

EULAR recommendations for the management of systemic lupus erythematosus: 2023 update.
Fanouriakis A, Kostopoulou M, Andersen J, Aringer M, Arnaud L, Bae SC, Boletis J, Bruce IN, Cervera R, Doria A, Dörner T, Furie RA, Gladman DD, Houssiau FA, Inês LS, Jayne D, Kouloumas M, Kovács L, Mok CC, Morand EF, Moroni G, Mosca M, Mucke J, Mukhtyar CB, Nagy G, Navarra S, Parodis I, Pego-Reigosa JM, Petri M, Pons-Estel BA, Schneider M, Smolen JS, Svenungsson E, Tanaka Y, Tektonidou MG, Teng YO, Tincani A, Vital EM, van Vollenhoven RF, Wincup C, Bertsias G, Boumpas DT
Ann Rheum Dis 2024 Jan 2;83(1):15-29. doi: 10.1136/ard-2023-224762. PMID: 37827694
Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy.
Rajasekaran A, Green TJ, Renfrow MB, Julian BA, Novak J, Rizk DV
Drugs 2023 Nov;83(16):1475-1499. Epub 2023 Sep 25 doi: 10.1007/s40265-023-01940-2. PMID: 37747686Free PMC Article
A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy.
Myette JR, Kano T, Suzuki H, Sloan SE, Szretter KJ, Ramakrishnan B, Adari H, Deotale KD, Engler F, Shriver Z, Wollacott AM, Suzuki Y, Pereira BJG
Kidney Int 2019 Jul;96(1):104-116. Epub 2019 Mar 16 doi: 10.1016/j.kint.2019.01.031. PMID: 31027890

Recent clinical studies

Therapy

Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects.
Wang Y, Buck A, Piel B, Zerefa L, Murugan N, Coherd CD, Miklosi AG, Johal H, Bastos RN, Huang K, Ficial M, Laimon YN, Signoretti S, Zhong Z, Hoang SM, Kastrunes GM, Grimaud M, Fayed A, Yuan HC, Nguyen QD, Thai T, Ivanova EV, Paweletz CP, Wu MR, Choueiri TK, Wee JO, Freeman GJ, Barbie DA, Marasco WA
Mol Cancer 2024 Mar 16;23(1):56. doi: 10.1186/s12943-024-01952-w. PMID: 38491381Free PMC Article
EULAR recommendations for the management of systemic lupus erythematosus: 2023 update.
Fanouriakis A, Kostopoulou M, Andersen J, Aringer M, Arnaud L, Bae SC, Boletis J, Bruce IN, Cervera R, Doria A, Dörner T, Furie RA, Gladman DD, Houssiau FA, Inês LS, Jayne D, Kouloumas M, Kovács L, Mok CC, Morand EF, Moroni G, Mosca M, Mucke J, Mukhtyar CB, Nagy G, Navarra S, Parodis I, Pego-Reigosa JM, Petri M, Pons-Estel BA, Schneider M, Smolen JS, Svenungsson E, Tanaka Y, Tektonidou MG, Teng YO, Tincani A, Vital EM, van Vollenhoven RF, Wincup C, Bertsias G, Boumpas DT
Ann Rheum Dis 2024 Jan 2;83(1):15-29. doi: 10.1136/ard-2023-224762. PMID: 37827694
A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy.
Myette JR, Kano T, Suzuki H, Sloan SE, Szretter KJ, Ramakrishnan B, Adari H, Deotale KD, Engler F, Shriver Z, Wollacott AM, Suzuki Y, Pereira BJG
Kidney Int 2019 Jul;96(1):104-116. Epub 2019 Mar 16 doi: 10.1016/j.kint.2019.01.031. PMID: 31027890
Drug-induced immune hemolytic anemia.
Garratty G
Hematology Am Soc Hematol Educ Program 2009:73-9. doi: 10.1182/asheducation-2009.1.73. PMID: 20008184
Sulfadiazine-induced nephrolithiasis in children.
Catalano-Pons C, Bargy S, Schlecht D, Tabone MD, Deschênes G, Bensman A, Ulinski T
Pediatr Nephrol 2004 Aug;19(8):928-31. Epub 2004 Jun 17 doi: 10.1007/s00467-004-1519-8. PMID: 15206032

Prognosis

Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy.
Rajasekaran A, Green TJ, Renfrow MB, Julian BA, Novak J, Rizk DV
Drugs 2023 Nov;83(16):1475-1499. Epub 2023 Sep 25 doi: 10.1007/s40265-023-01940-2. PMID: 37747686Free PMC Article
Clinical significance of IgM and C3 deposition in children with primary immunoglobulin A nephropathy.
Xiong L, Liu L, Tao Y, Guo H
J Nephrol 2023 Nov;36(8):2213-2222. Epub 2023 Aug 5 doi: 10.1007/s40620-023-01724-7. PMID: 37542609
A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy.
Myette JR, Kano T, Suzuki H, Sloan SE, Szretter KJ, Ramakrishnan B, Adari H, Deotale KD, Engler F, Shriver Z, Wollacott AM, Suzuki Y, Pereira BJG
Kidney Int 2019 Jul;96(1):104-116. Epub 2019 Mar 16 doi: 10.1016/j.kint.2019.01.031. PMID: 31027890
The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy.
Rizk DV, Maillard N, Julian BA, Knoppova B, Green TJ, Novak J, Wyatt RJ
Front Immunol 2019;10:504. Epub 2019 Mar 19 doi: 10.3389/fimmu.2019.00504. PMID: 30941137Free PMC Article
Primary biliary cirrhosis.
Moreno-Otero R, Lisker-Melman M, Jones EA
Med Clin North Am 1989 Jul;73(4):911-29. doi: 10.1016/s0025-7125(16)30645-9. PMID: 2657267

Clinical prediction guides

Regulation of HHLA2 expression in kidney cancer and myeloid cells.
Shigemura T, Perrot N, Huang Z, Bhatt RS, Sheshdeh AB, Ahmar NE, Ghandour F, Signoretti S, McDermott DF, Freeman GJ, Mahoney KM
BMC Cancer 2023 Oct 27;23(1):1039. doi: 10.1186/s12885-023-11496-9. PMID: 37891555Free PMC Article
Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy.
Rajasekaran A, Green TJ, Renfrow MB, Julian BA, Novak J, Rizk DV
Drugs 2023 Nov;83(16):1475-1499. Epub 2023 Sep 25 doi: 10.1007/s40265-023-01940-2. PMID: 37747686Free PMC Article
Clinical significance of IgM and C3 deposition in children with primary immunoglobulin A nephropathy.
Xiong L, Liu L, Tao Y, Guo H
J Nephrol 2023 Nov;36(8):2213-2222. Epub 2023 Aug 5 doi: 10.1007/s40620-023-01724-7. PMID: 37542609
Schistosomiasis-associated glomerulopathy: Clinical aspects, pathological characteristics, and renal outcomes
.
Neves PDMM, Jorge LB, Cavalcante LB, Malheiros D, Woronik V, Dias CB
Clin Nephrol 2020 May;93(5):251-261. doi: 10.5414/CN110013. PMID: 32228829
A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy.
Myette JR, Kano T, Suzuki H, Sloan SE, Szretter KJ, Ramakrishnan B, Adari H, Deotale KD, Engler F, Shriver Z, Wollacott AM, Suzuki Y, Pereira BJG
Kidney Int 2019 Jul;96(1):104-116. Epub 2019 Mar 16 doi: 10.1016/j.kint.2019.01.031. PMID: 31027890

Recent systematic reviews

Systematic Review of the Efficacy and Safety of Traditional Chinese Medicine Granules Associated with Hormone When Treating Primary Nephrotic Syndrome in Children.
Zhang L, Chen L
Contrast Media Mol Imaging 2022;2022:2520367. Epub 2022 Sep 27 doi: 10.1155/2022/2520367. PMID: 36247855Free PMC Article
Association between Toxoplasma gondii Infection and Nephrotic Syndrome Risk in Children: A Case-Control Study and Systematic Review.
Sorkhi H, Mollalo A, Bijani A, Mehravar S, Pournasrollah M, Sadr Moharerpour S, Rostami A
J Trop Pediatr 2022 Aug 4;68(5) doi: 10.1093/tropej/fmac067. PMID: 35950309
Adjuvant treatment with Yupingfeng formula for primary nephrotic syndrome in children: A PRISMA systematic review and meta-analysis of randomized controlled trials.
Shi X, Zhong X, Ding J
Medicine (Baltimore) 2018 Jul;97(29):e11598. doi: 10.1097/MD.0000000000011598. PMID: 30024564Free PMC Article
Treatment for hepatitis C virus-associated mixed cryoglobulinaemia.
Montero N, Favà A, Rodriguez E, Barrios C, Cruzado JM, Pascual J, Soler MJ
Cochrane Database Syst Rev 2018 May 7;5(5):CD011403. doi: 10.1002/14651858.CD011403.pub2. PMID: 29734473Free PMC Article

Supplemental Content

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