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Chemotherapeutic Drug - Induced Nephropathy

MedGen UID:
886988
•Concept ID:
C4055261
•
Disease or Syndrome

Definition

Kidney damage resulting from exposure to chemotherapeutic drugs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChemotherapeutic Drug - Induced Nephropathy

Professional guidelines

PubMed

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases.
Wang Y, Hu J, Wu S, Fleishman JS, Li Y, Xu Y, Zou W, Wang J, Feng Y, Chen J, Wang H
Signal Transduct Target Ther 2023 Dec 10;8(1):449. doi: 10.1038/s41392-023-01720-0. PMID: 38072908Free PMC Article
Nephrotoxicity as a Complication of Chemotherapy and Immunotherapy in the Treatment of Colorectal Cancer, Melanoma and Non-Small Cell Lung Cancer.
Jagieła J, Bartnicki P, Rysz J
Int J Mol Sci 2021 Apr 28;22(9) doi: 10.3390/ijms22094618. PMID: 33924827Free PMC Article
Nephrotoxicity of anticancer treatment.
Malyszko J, Kozlowska K, Kozlowski L, Malyszko J
Nephrol Dial Transplant 2017 Jun 1;32(6):924-936. doi: 10.1093/ndt/gfw338. PMID: 28339935

Recent clinical studies

Etiology

Cisplatin Nephrotoxicity: Novel Insights Into Mechanisms and Preventative Strategies.
Motwani SS, Kaur SS, Kitchlu A
Semin Nephrol 2022 Nov;42(6):151341. Epub 2023 May 12 doi: 10.1016/j.semnephrol.2023.151341. PMID: 37182407
Nephrotoxicity as a Complication of Chemotherapy and Immunotherapy in the Treatment of Colorectal Cancer, Melanoma and Non-Small Cell Lung Cancer.
Jagieła J, Bartnicki P, Rysz J
Int J Mol Sci 2021 Apr 28;22(9) doi: 10.3390/ijms22094618. PMID: 33924827Free PMC Article
Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics.
Weng Q, Sun H, Fang C, Xia F, Liao H, Lee J, Wang J, Xie A, Ren J, Guo X, Li F, Yang B, Ling D
Nat Commun 2021 Mar 4;12(1):1436. doi: 10.1038/s41467-021-21714-2. PMID: 33664241Free PMC Article
Drug-induced nephrotoxicity.
Sales GTM, Foresto RD
Rev Assoc Med Bras (1992) 2020 Jan 13;66Suppl 1(Suppl 1):s82-s90. doi: 10.1590/1806-9282.66.S1.82. PMID: 31939540
Drug-induced Nephrotoxicity and Medicinal Plants.
Khajavi Rad A, Mohebbati R, Hosseinian S
Iran J Kidney Dis 2017 May;11(3):169-179. PMID: 28575877

Diagnosis

Cisplatin Nephrotoxicity: Novel Insights Into Mechanisms and Preventative Strategies.
Motwani SS, Kaur SS, Kitchlu A
Semin Nephrol 2022 Nov;42(6):151341. Epub 2023 May 12 doi: 10.1016/j.semnephrol.2023.151341. PMID: 37182407
Drug-induced nephrotoxicity.
Sales GTM, Foresto RD
Rev Assoc Med Bras (1992) 2020 Jan 13;66Suppl 1(Suppl 1):s82-s90. doi: 10.1590/1806-9282.66.S1.82. PMID: 31939540
Cardiorenal complications of immune checkpoint inhibitors.
Sury K, Perazella MA, Shirali AC
Nat Rev Nephrol 2018 Sep;14(9):571-588. doi: 10.1038/s41581-018-0035-1. PMID: 30013100
Drug-Induced Kidney Injury in the Elderly.
Khan S, Loi V, Rosner MH
Drugs Aging 2017 Oct;34(10):729-741. doi: 10.1007/s40266-017-0484-4. PMID: 28815461
Nephrotoxicity of anticancer treatment.
Malyszko J, Kozlowska K, Kozlowski L, Malyszko J
Nephrol Dial Transplant 2017 Jun 1;32(6):924-936. doi: 10.1093/ndt/gfw338. PMID: 28339935

Therapy

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases.
Wang Y, Hu J, Wu S, Fleishman JS, Li Y, Xu Y, Zou W, Wang J, Feng Y, Chen J, Wang H
Signal Transduct Target Ther 2023 Dec 10;8(1):449. doi: 10.1038/s41392-023-01720-0. PMID: 38072908Free PMC Article
Onconephrology.
Kala J, Finkel KW
Crit Care Clin 2021 Apr;37(2):365-384. Epub 2021 Feb 13 doi: 10.1016/j.ccc.2020.11.004. PMID: 33752861
Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity.
Shen X, Wang H, Weng C, Jiang H, Chen J
Cell Death Dis 2021 Feb 15;12(2):186. doi: 10.1038/s41419-021-03458-5. PMID: 33589596Free PMC Article
Recent Advances in Models, Mechanisms, Biomarkers, and Interventions in Cisplatin-Induced Acute Kidney Injury.
Holditch SJ, Brown CN, Lombardi AM, Nguyen KN, Edelstein CL
Int J Mol Sci 2019 Jun 20;20(12) doi: 10.3390/ijms20123011. PMID: 31226747Free PMC Article
Pathophysiology of cisplatin-induced acute kidney injury.
Ozkok A, Edelstein CL
Biomed Res Int 2014;2014:967826. Epub 2014 Aug 6 doi: 10.1155/2014/967826. PMID: 25165721Free PMC Article

Prognosis

The link between kidney disease and cancer: complications and treatment.
Malyszko J, Tesarova P, Capasso G, Capasso A
Lancet 2020 Jul 25;396(10246):277-287. doi: 10.1016/S0140-6736(20)30540-7. PMID: 32711803
Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches.
Rodrigues D, Souza T, Jennen DGJ, Lemmens L, Kleinjans JCS, de Kok TM
Cancer Treat Rev 2019 Jul;77:57-66. Epub 2019 Jun 27 doi: 10.1016/j.ctrv.2019.06.004. PMID: 31279169
Medication-Induced Interstitial Nephritis in the 21st Century.
Nast CC
Adv Chronic Kidney Dis 2017 Mar;24(2):72-79. doi: 10.1053/j.ackd.2016.11.016. PMID: 28284382
Nephrotoxicity of semustine.
Weiss RB, Posada JG Jr, Kramer RA, Boyd MR
Cancer Treat Rep 1983 Dec;67(12):1105-12. PMID: 6360348
Minireview. The nephrotoxicity of cisplatin.
Goldstein RS, Mayor GH
Life Sci 1983 Feb 14;32(7):685-90. doi: 10.1016/0024-3205(83)90299-0. PMID: 6338333

Clinical prediction guides

Beta vulgaris-derived exosome-like nanovesicles alleviate chronic doxorubicin-induced cardiotoxicity by inhibiting ferroptosis.
Cai J, Pan J
J Biochem Mol Toxicol 2024 Jan;38(1):e23540. Epub 2023 Sep 20 doi: 10.1002/jbt.23540. PMID: 37728183
The link between kidney disease and cancer: complications and treatment.
Malyszko J, Tesarova P, Capasso G, Capasso A
Lancet 2020 Jul 25;396(10246):277-287. doi: 10.1016/S0140-6736(20)30540-7. PMID: 32711803
Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches.
Rodrigues D, Souza T, Jennen DGJ, Lemmens L, Kleinjans JCS, de Kok TM
Cancer Treat Rev 2019 Jul;77:57-66. Epub 2019 Jun 27 doi: 10.1016/j.ctrv.2019.06.004. PMID: 31279169
Update on the nephrotoxicity of novel anticancer agents
.
Nussbaum EZ, Perazella MA
Clin Nephrol 2018 Mar;89(3):149-165. doi: 10.5414/CN109371. PMID: 29350175
Renal disease in patients with cancer.
Finkel KW, Foringer JR
Nat Clin Pract Nephrol 2007 Dec;3(12):669-78. doi: 10.1038/ncpneph0622. PMID: 18033226

Recent systematic reviews

Long-term cisplatin nephrotoxicity after childhood cancer: a systematic review and meta-analysis.
Schofield J, Harcus M, Pizer B, Jorgensen A, McWilliam S
Pediatr Nephrol 2024 Mar;39(3):699-710. Epub 2023 Sep 20 doi: 10.1007/s00467-023-06149-9. PMID: 37726572Free PMC Article
A systematic review of the accuracy and utility of early markers of Ifosfamide-induced proximal tubulopathy in survivors of childhood cancers.
Phillips RS, Tyerman K, Al-Kassim MI, Picton S
Pediatr Hematol Oncol 2008 Mar;25(2):107-13. doi: 10.1080/08880010701885276. PMID: 18363176

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