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Reflux Nephropathy

MedGen UID:
886472
•Concept ID:
C3495566
•
Disease or Syndrome

Definition

Chronic kidney damage due to vesicoureteral reflux. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReflux Nephropathy

Professional guidelines

PubMed

Guidelines for the medical management of pediatric vesicoureteral reflux.
Miyakita H, Hayashi Y, Mitsui T, Okawada M, Kinoshita Y, Kimata T, Koikawa Y, Sakai K, Satoh H, Tokunaga M, Naitoh Y, Niimura F, Matsuoka H, Mizuno K, Kaneko K, Kubota M
Int J Urol 2020 Jun;27(6):480-490. Epub 2020 Apr 1 doi: 10.1111/iju.14223. PMID: 32239562Free PMC Article
Current Management of Urinary Tract Infection and Vesicoureteral Reflux.
Thergaonkar RW, Hari P
Indian J Pediatr 2020 Aug;87(8):625-632. Epub 2019 Dec 11 doi: 10.1007/s12098-019-03099-9. PMID: 31828601
Controversies Regarding Management of Vesico-ureteric Reflux.
Babu R, Chowdhary S
Indian J Pediatr 2017 Jul;84(7):540-544. Epub 2017 May 6 doi: 10.1007/s12098-017-2359-4. PMID: 28477320

Recent clinical studies

Therapy

Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology.
Lee AM, Hu J, Xu Y, Abraham AG, Xiao R, Coresh J, Rebholz C, Chen J, Rhee EP, Feldman HI, Ramachandran VS, Kimmel PL, Warady BA, Furth SL, Denburg MR; CKD Biomarkers Consortium
J Am Soc Nephrol 2022 Feb;33(2):375-386. Epub 2022 Jan 11 doi: 10.1681/ASN.2021040538. PMID: 35017168Free PMC Article
Vesicoureteral reflux is it important to find?
Hewitt I, Montini G
Pediatr Nephrol 2021 Apr;36(4):1011-1017. Epub 2020 Apr 22 doi: 10.1007/s00467-020-04573-9. PMID: 32323004
Controversies Regarding Management of Vesico-ureteric Reflux.
Babu R, Chowdhary S
Indian J Pediatr 2017 Jul;84(7):540-544. Epub 2017 May 6 doi: 10.1007/s12098-017-2359-4. PMID: 28477320
Vesicoureteral reflux in pediatric age: where are we today?
Altobelli E, Gerocarni Nappo S, Guidotti M, Caione P
Urologia 2014 Apr-Jun;81(2):76-87. doi: 10.5301/urologia.5000052. PMID: 25083520
Familial vesicoureteral reflux.
Chertin B, Puri P
J Urol 2003 May;169(5):1804-8. doi: 10.1097/01.ju.0000058428.00284.d5. PMID: 12686848

Prognosis

Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology.
Lee AM, Hu J, Xu Y, Abraham AG, Xiao R, Coresh J, Rebholz C, Chen J, Rhee EP, Feldman HI, Ramachandran VS, Kimmel PL, Warady BA, Furth SL, Denburg MR; CKD Biomarkers Consortium
J Am Soc Nephrol 2022 Feb;33(2):375-386. Epub 2022 Jan 11 doi: 10.1681/ASN.2021040538. PMID: 35017168Free PMC Article
Guidelines for the medical management of pediatric vesicoureteral reflux.
Miyakita H, Hayashi Y, Mitsui T, Okawada M, Kinoshita Y, Kimata T, Koikawa Y, Sakai K, Satoh H, Tokunaga M, Naitoh Y, Niimura F, Matsuoka H, Mizuno K, Kaneko K, Kubota M
Int J Urol 2020 Jun;27(6):480-490. Epub 2020 Apr 1 doi: 10.1111/iju.14223. PMID: 32239562Free PMC Article
Vesicoureteral reflux in pediatric age: where are we today?
Altobelli E, Gerocarni Nappo S, Guidotti M, Caione P
Urologia 2014 Apr-Jun;81(2):76-87. doi: 10.5301/urologia.5000052. PMID: 25083520
Vesicoureteral reflux and reflux nephropathy.
Mattoo TK
Adv Chronic Kidney Dis 2011 Sep;18(5):348-54. doi: 10.1053/j.ackd.2011.07.006. PMID: 21896376Free PMC Article
Familial vesicoureteral reflux.
Chertin B, Puri P
J Urol 2003 May;169(5):1804-8. doi: 10.1097/01.ju.0000058428.00284.d5. PMID: 12686848

Clinical prediction guides

Reflux nephropathy and scarring nephropathy: So close and yet so different.
García Nieto VM, Monge Zamorano M, Antón Hernández L, Luis Yanes MI, Tejera Carreño P, Moraleda Mesa T
An Pediatr (Engl Ed) 2022 Jul;97(1):40-47. Epub 2022 Jul 2 doi: 10.1016/j.anpede.2021.08.008. PMID: 35788336
Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology.
Lee AM, Hu J, Xu Y, Abraham AG, Xiao R, Coresh J, Rebholz C, Chen J, Rhee EP, Feldman HI, Ramachandran VS, Kimmel PL, Warady BA, Furth SL, Denburg MR; CKD Biomarkers Consortium
J Am Soc Nephrol 2022 Feb;33(2):375-386. Epub 2022 Jan 11 doi: 10.1681/ASN.2021040538. PMID: 35017168Free PMC Article
Guidelines for the medical management of pediatric vesicoureteral reflux.
Miyakita H, Hayashi Y, Mitsui T, Okawada M, Kinoshita Y, Kimata T, Koikawa Y, Sakai K, Satoh H, Tokunaga M, Naitoh Y, Niimura F, Matsuoka H, Mizuno K, Kaneko K, Kubota M
Int J Urol 2020 Jun;27(6):480-490. Epub 2020 Apr 1 doi: 10.1111/iju.14223. PMID: 32239562Free PMC Article
Vesicoureteral reflux and reflux nephropathy.
Mattoo TK
Adv Chronic Kidney Dis 2011 Sep;18(5):348-54. doi: 10.1053/j.ackd.2011.07.006. PMID: 21896376Free PMC Article
Reflux nephropathy and hypertension.
Goonasekera CD, Dillon MJ
J Hum Hypertens 1998 Aug;12(8):497-504. doi: 10.1038/sj.jhh.1000653. PMID: 9759982

Recent systematic reviews

PIC cystography in occult vesicoureteral reflux: A systematic review highlighting its utility in children with recurrent urinary tract infections and normal VCUG.
Pakkasjärvi N, Ripatti L, Läckgren G, Krishnan N, Anand S
J Pediatr Urol 2023 Dec;19(6):804-811. Epub 2023 Aug 15 doi: 10.1016/j.jpurol.2023.08.008. PMID: 37633825
Reflux nephropathy and the risk of preeclampsia and of other adverse pregnancy-related outcomes: a systematic review and meta-analysis of case series and reports in the new millennium.
Attini R, Kooij I, Montersino B, Fassio F, Gerbino M, Biolcati M, Versino E, Todros T, Piccoli GB
J Nephrol 2018 Dec;31(6):833-846. Epub 2018 Jul 31 doi: 10.1007/s40620-018-0515-1. PMID: 30066252
Out-of-office blood pressure and target organ damage in children and adolescents: a systematic review and meta-analysis.
Kollias A, Dafni M, Poulidakis E, Ntineri A, Stergiou GS
J Hypertens 2014 Dec;32(12):2315-31; discussion 2331. doi: 10.1097/HJH.0000000000000384. PMID: 25304469

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