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Pseudopelade of Brocq

MedGen UID:
88640
•Concept ID:
C0086873
•
Disease or Syndrome
Synonyms: Brocq pseudopelade; Pseudo-pelade of Brocq
SNOMED CT: Pseudopelade of Brocq (238731001); Alopecia cicatrisata (400088006); Pseudopelade (238731001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015261
Orphanet: ORPHA129

Definition

Pseudo-pelade of Brocq is a rare hair abnormality characterized by onset in adulthood of soft, irregular, flesh-toned patches of alopecia primarily in the parietal and vertex portions of the scalp, without follicular hyperkeratosis or perifollicular inflammation. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudopelade of Brocq
Follow this link to review classifications for Pseudopelade of Brocq in Orphanet.

Professional guidelines

PubMed

Diagnosis and management of primary cicatricial alopecia: part I.
Otberg N, Wu WY, McElwee KJ, Shapiro J
Skinmed 2008 Jan-Feb;7(1):19-26. doi: 10.1111/j.1540-9740.2007.07163.x. PMID: 18174797
Value of direct immunofluorescence for differential diagnosis of cicatricial alopecia.
Trachsler S, Trueb RM
Dermatology 2005;211(2):98-102. doi: 10.1159/000086436. PMID: 16088153

Recent clinical studies

Etiology

Have Skin Biopsy Results in Adults Been Affected in the COVID-19 Pandemic?
Çölgeçen E, Gökçek GE, Şahin S
Acta Dermatovenerol Croat 2022 Jul;30(1):40-48. PMID: 36153718
Primary scarring alopecia: A retrospective study of 89 patients in Taiwan.
Su HJ, Cheng AY, Liu CH, Chu CB, Lee CN, Hsu CK, Lee JY, Yang CC
J Dermatol 2018 Apr;45(4):450-455. Epub 2018 Jan 16 doi: 10.1111/1346-8138.14217. PMID: 29341216
Clinical features of primary cicatricial alopecia in Chinese patients.
Qi S, Zhao Y, Zhang X, Li S, Cao H, Zhang X
Indian J Dermatol Venereol Leprol 2014 Jul-Aug;80(4):306-12. doi: 10.4103/0378-6323.136833. PMID: 25035354
Alopecia areata mimicking pseudopelade of Brocq.
Kittridge A, Haught JM, English JC 3rd
Cutis 2010 Oct;86(4):187-9. PMID: 21140926
Differential patterns of elastic fibers in scarring and non-scarring alopecias.
Pinkus H
J Cutan Pathol 1978 Jun;5(3):93-104. doi: 10.1111/j.1600-0560.1978.tb00946.x. PMID: 79579

Diagnosis

Histopathology of alopecia: a clinicopathological approach to diagnosis.
Stefanato CM
Histopathology 2010 Jan;56(1):24-38. doi: 10.1111/j.1365-2559.2009.03439.x. PMID: 20055903
Lichen planopilaris and pseudopelade of Brocq involve distinct disease associated gene expression patterns by microarray.
Yu M, Bell RH, Ross EK, Lo BK, Isaac-Renton M, Martinka M, Haegert A, Shapiro J, McElwee KJ
J Dermatol Sci 2010 Jan;57(1):27-36. Epub 2009 Nov 22 doi: 10.1016/j.jdermsci.2009.10.011. PMID: 19932600
Pseudopelade of Brocq.
Alzolibani AA, Kang H, Otberg N, Shapiro J
Dermatol Ther 2008 Jul-Aug;21(4):257-63. doi: 10.1111/j.1529-8019.2008.00207.x. PMID: 18715295
Diagnosis and management of primary cicatricial alopecia: part I.
Otberg N, Wu WY, McElwee KJ, Shapiro J
Skinmed 2008 Jan-Feb;7(1):19-26. doi: 10.1111/j.1540-9740.2007.07163.x. PMID: 18174797
Pseudopelade of Brocq.
Braun-Falco O, Imai S, Schmoeckel C, Steger O, Bergner T
Dermatologica 1986;172(1):18-23. doi: 10.1159/000249287. PMID: 3956816

Therapy

Alopecia areata mimicking pseudopelade of Brocq.
Kittridge A, Haught JM, English JC 3rd
Cutis 2010 Oct;86(4):187-9. PMID: 21140926
Pseudopelade of Brocq in a child.
Bulengo-Ransby SM, Headington JT
J Am Acad Dermatol 1990 Nov;23(5 Pt 1):944-5. doi: 10.1016/s0190-9622(08)80706-2. PMID: 2135949

Prognosis

Clinical features of primary cicatricial alopecia in Chinese patients.
Qi S, Zhao Y, Zhang X, Li S, Cao H, Zhang X
Indian J Dermatol Venereol Leprol 2014 Jul-Aug;80(4):306-12. doi: 10.4103/0378-6323.136833. PMID: 25035354
Alopecia areata mimicking pseudopelade of Brocq.
Kittridge A, Haught JM, English JC 3rd
Cutis 2010 Oct;86(4):187-9. PMID: 21140926
Pseudopelade of Brocq.
Alzolibani AA, Kang H, Otberg N, Shapiro J
Dermatol Ther 2008 Jul-Aug;21(4):257-63. doi: 10.1111/j.1529-8019.2008.00207.x. PMID: 18715295
Pseudopelade of Brocq.
Braun-Falco O, Imai S, Schmoeckel C, Steger O, Bergner T
Dermatologica 1986;172(1):18-23. doi: 10.1159/000249287. PMID: 3956816

Clinical prediction guides

Have Skin Biopsy Results in Adults Been Affected in the COVID-19 Pandemic?
Çölgeçen E, Gökçek GE, Şahin S
Acta Dermatovenerol Croat 2022 Jul;30(1):40-48. PMID: 36153718
Evaluation of inflammatory infiltrate and fibrogenic cytokines in pseudopelade of Brocq suggests the involvement of T-helper 2 and 3 cytokines.
Moretti S, Amato L, Massi D, Bianchi B, Gallerani I, Fabbri P
Br J Dermatol 2004 Jul;151(1):84-90. doi: 10.1111/j.1365-2133.2004.05976.x. PMID: 15270875

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