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Diffuse lupus nephritis

MedGen UID:
883248
Concept ID:
C4053955
Disease or Syndrome
Synonyms: Class IV lupus nephritis; Systemic Lupus Erythematosus Nephritis Class IV
 
HPO: HP:0033727

Definition

A subclass of lupus nephritis with active or inactive diffuse, segmental or global endocapillary or extracapillary glomerulonephritis involving at least 50% of all glomeruli, typically with diffuse subendothelial immune deposits, with or without mesangial alterations. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse lupus nephritis

Professional guidelines

PubMed

Al-Adhoubi NK, Bystrom J
Lupus 2020 Apr;29(4):355-363. Epub 2020 Feb 9 doi: 10.1177/0961203320903798. PMID: 32036761Free PMC Article
Flanc RS, Roberts MA, Strippoli GF, Chadban SJ, Kerr PG, Atkins RC
Cochrane Database Syst Rev 2004;(1):CD002922. doi: 10.1002/14651858.CD002922.pub2. PMID: 14973998
Pollak VE, Kant KS, Hariharan S
Nephron 1991;59(2):177-93. doi: 10.1159/000186550. PMID: 1956480

Recent clinical studies

Etiology

Caza TN, Cassol CA, Messias N, Hannoudi A, Haun RS, Walker PD, May RM, Seipp RM, Betchick EJ, Amin H, Ziadie MS, Haderlie M, Eduwu-Okwuwa J, Vancea I, Seek M, Elashi EB, Shenoy G, Khalillullah S, Flaxenburg JA, Brandt J, Diamond MJ, Frome A, Kim EH, Schlessinger G, Ulozas E, Weatherspoon JL, Hoerschgen ET, Fabian SL, Bae SY, Iqbal B, Chouhan KK, Karam Z, Henry JT, Larsen CP
Kidney360 2021 Nov 25;2(11):1770-1780. Epub 2021 Sep 16 doi: 10.34067/KID.0005372021. PMID: 35372991Free PMC Article
Chen YE, Korbet SM, Katz RS, Schwartz MM, Lewis EJ; Collaborative Study Group
Clin J Am Soc Nephrol 2008 Jan;3(1):46-53. Epub 2007 Nov 14 doi: 10.2215/CJN.03280807. PMID: 18003764Free PMC Article
Moroni G, Doria A, Mosca M, Alberighi OD, Ferraccioli G, Todesco S, Manno C, Altieri P, Ferrara R, Greco S, Ponticelli C
Clin J Am Soc Nephrol 2006 Sep;1(5):925-32. Epub 2006 Jun 28 doi: 10.2215/CJN.02271205. PMID: 17699309
Ponticelli C, Zucchelli P, Moroni G, Cagnoli L, Banfi G, Pasquali S
Clin Nephrol 1987 Dec;28(6):263-71. PMID: 3327639
Leehey DJ, Katz AI, Azaran AH, Aronson AJ, Spargo BH
Am J Kidney Dis 1982 Jul;2(1 Suppl 1):188-96. PMID: 7048906

Diagnosis

Fang YH, Lin HH, Lou JG, Chen J
Zhongguo Dang Dai Er Ke Za Zhi 2022 Aug 15;24(8):917-922. doi: 10.7499/j.issn.1008-8830.2203006. PMID: 36036131Free PMC Article
Fogo AB, Lusco MA, Najafian B, Alpers CE
Am J Kidney Dis 2017 Aug;70(2):e9-e11. doi: 10.1053/j.ajkd.2017.06.001. PMID: 28739130
Medina G, González-Pérez D, Vázquez-Juárez C, Sánchez-Uribe M, Saavedra MA, Jara LJ
Lupus 2014 Nov;23(13):1426-9. Epub 2014 Aug 8 doi: 10.1177/0961203314546018. PMID: 25107938
Ponticelli C, Zucchelli P, Moroni G, Cagnoli L, Banfi G, Pasquali S
Clin Nephrol 1987 Dec;28(6):263-71. PMID: 3327639
Ginzler EM, Nicastri AD, Chen CK, Friedman EA, Diamond HS, Kaplan D
N Engl J Med 1974 Oct 3;291(14):693-6. doi: 10.1056/NEJM197410032911402. PMID: 4604972

Therapy

Caza TN, Cassol CA, Messias N, Hannoudi A, Haun RS, Walker PD, May RM, Seipp RM, Betchick EJ, Amin H, Ziadie MS, Haderlie M, Eduwu-Okwuwa J, Vancea I, Seek M, Elashi EB, Shenoy G, Khalillullah S, Flaxenburg JA, Brandt J, Diamond MJ, Frome A, Kim EH, Schlessinger G, Ulozas E, Weatherspoon JL, Hoerschgen ET, Fabian SL, Bae SY, Iqbal B, Chouhan KK, Karam Z, Henry JT, Larsen CP
Kidney360 2021 Nov 25;2(11):1770-1780. Epub 2021 Sep 16 doi: 10.34067/KID.0005372021. PMID: 35372991Free PMC Article
Chen W, Liu Q, Chen W, Tang X, Fu P, Liu F, Liao Y, Yang Z, Zhang J, Chen J, Lou T, Fu J, Kong Y, Liu Z, Li Z, Yu X
Lupus 2012 Aug;21(9):944-52. Epub 2012 Mar 21 doi: 10.1177/0961203312442259. PMID: 22438027
Moroni G, Doria A, Mosca M, Alberighi OD, Ferraccioli G, Todesco S, Manno C, Altieri P, Ferrara R, Greco S, Ponticelli C
Clin J Am Soc Nephrol 2006 Sep;1(5):925-32. Epub 2006 Jun 28 doi: 10.2215/CJN.02271205. PMID: 17699309
Ponticelli C, Zucchelli P, Moroni G, Cagnoli L, Banfi G, Pasquali S
Clin Nephrol 1987 Dec;28(6):263-71. PMID: 3327639
Leehey DJ, Katz AI, Azaran AH, Aronson AJ, Spargo BH
Am J Kidney Dis 1982 Jul;2(1 Suppl 1):188-96. PMID: 7048906

Prognosis

Medina G, González-Pérez D, Vázquez-Juárez C, Sánchez-Uribe M, Saavedra MA, Jara LJ
Lupus 2014 Nov;23(13):1426-9. Epub 2014 Aug 8 doi: 10.1177/0961203314546018. PMID: 25107938
Nakashima H, Akahoshi M, Masutani K
Rinsho Byori 2006 Jul;54(7):706-13. PMID: 16913661
Ponticelli C, Zucchelli P, Moroni G, Cagnoli L, Banfi G, Pasquali S
Clin Nephrol 1987 Dec;28(6):263-71. PMID: 3327639
Leehey DJ, Katz AI, Azaran AH, Aronson AJ, Spargo BH
Am J Kidney Dis 1982 Jul;2(1 Suppl 1):188-96. PMID: 7048906
Ginzler EM, Nicastri AD, Chen CK, Friedman EA, Diamond HS, Kaplan D
N Engl J Med 1974 Oct 3;291(14):693-6. doi: 10.1056/NEJM197410032911402. PMID: 4604972

Clinical prediction guides

Fang YH, Lin HH, Lou JG, Chen J
Zhongguo Dang Dai Er Ke Za Zhi 2022 Aug 15;24(8):917-922. doi: 10.7499/j.issn.1008-8830.2203006. PMID: 36036131Free PMC Article
Nakashima H, Akahoshi M, Masutani K
Rinsho Byori 2006 Jul;54(7):706-13. PMID: 16913661
Su CF, Chen HH, Yeh JC, Chen SC, Liu CC, Tzen CY
Nephron 2002 Jan;90(1):37-42. doi: 10.1159/000046312. PMID: 11744803
Grishman E, Gerber MA, Churg J
Am J Kidney Dis 1982 Jul;2(1 Suppl 1):135-41. PMID: 6213149

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