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Leukoplakia of anus

MedGen UID:
87417
•Concept ID:
C0341325
•
Disease or Syndrome
Synonyms: Anal Leukoplakia; Leukoplakia of Anus; Leukoplakia of the Anus
SNOMED CT: Leukoplakia of anus (235743004)

Definition

The presence of a painless whitish patch on the anal mucosa. Histologic examination reveals hyperkeratosis and acanthosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukoplakia of anus

Recent clinical studies

Etiology

Irregularly shaped leucoplakic lesion of the anus. Diagnosis: anal intraepithelial neoplasia (AIN).
Kreuter A, Brockmeyer NH, Wieland U; German Competence Network HIV/AIDS
Clin Exp Dermatol 2007 Sep;32(5):621-3. Epub 2007 Apr 11 doi: 10.1111/j.1365-2230.2007.02416.x. PMID: 17425644
Clinical presentation of minimally invasive and in situ squamous cell carcinoma of the anus in homosexual men.
Forti RL, Medwell SJ, Aboulafia DM, Surawicz CM, Spach DH
Clin Infect Dis 1995 Sep;21(3):603-7. doi: 10.1093/clinids/21.3.603. PMID: 8527551
Intraepithelial neoplasia of the anal canal in hemorrhoidal tissue: a study of 19 cases.
Foust RL, Dean PJ, Stoler MH, Moinuddin SM
Hum Pathol 1991 Jun;22(6):528-34. doi: 10.1016/0046-8177(91)90228-h. PMID: 1650751
Leukoplakia of the anal canal.
Bender MD, Lechago J
Am J Dig Dis 1976 Oct;21(10):867-72. doi: 10.1007/BF01072079. PMID: 1015495

Diagnosis

High-resolution anoscopy: clinical features of anal intraepithelial neoplasia in HIV-positive men.
Richel O, Hallensleben ND, Kreuter A, van Noesel CJ, Prins JM, de Vries HJ
Dis Colon Rectum 2013 Nov;56(11):1237-42. doi: 10.1097/DCR.0b013e3182a53568. PMID: 24104998
Clinical presentation of minimally invasive and in situ squamous cell carcinoma of the anus in homosexual men.
Forti RL, Medwell SJ, Aboulafia DM, Surawicz CM, Spach DH
Clin Infect Dis 1995 Sep;21(3):603-7. doi: 10.1093/clinids/21.3.603. PMID: 8527551
Leukoplakia of the anal canal.
Bender MD, Lechago J
Am J Dig Dis 1976 Oct;21(10):867-72. doi: 10.1007/BF01072079. PMID: 1015495
Problems of verrucose squamous carcinoma.
Elliott GB, Macdougall JA, Elliott JD
Ann Surg 1973 Jan;177(1):21-9. doi: 10.1097/00000658-197301000-00005. PMID: 4566093Free PMC Article
Leukoplakia of the anus.
GRODSKY L
Calif Med 1956 Jun;84(6):420-3. PMID: 13316552Free PMC Article

Prognosis

High-resolution anoscopy: clinical features of anal intraepithelial neoplasia in HIV-positive men.
Richel O, Hallensleben ND, Kreuter A, van Noesel CJ, Prins JM, de Vries HJ
Dis Colon Rectum 2013 Nov;56(11):1237-42. doi: 10.1097/DCR.0b013e3182a53568. PMID: 24104998
Intraepithelial neoplasia of the anal canal in hemorrhoidal tissue: a study of 19 cases.
Foust RL, Dean PJ, Stoler MH, Moinuddin SM
Hum Pathol 1991 Jun;22(6):528-34. doi: 10.1016/0046-8177(91)90228-h. PMID: 1650751
Leukoplakia of the anal canal.
Bender MD, Lechago J
Am J Dig Dis 1976 Oct;21(10):867-72. doi: 10.1007/BF01072079. PMID: 1015495
Leukoplakia of the anus.
GRODSKY L
Calif Med 1956 Jun;84(6):420-3. PMID: 13316552Free PMC Article

Clinical prediction guides

High-resolution anoscopy: clinical features of anal intraepithelial neoplasia in HIV-positive men.
Richel O, Hallensleben ND, Kreuter A, van Noesel CJ, Prins JM, de Vries HJ
Dis Colon Rectum 2013 Nov;56(11):1237-42. doi: 10.1097/DCR.0b013e3182a53568. PMID: 24104998
Clinical presentation of minimally invasive and in situ squamous cell carcinoma of the anus in homosexual men.
Forti RL, Medwell SJ, Aboulafia DM, Surawicz CM, Spach DH
Clin Infect Dis 1995 Sep;21(3):603-7. doi: 10.1093/clinids/21.3.603. PMID: 8527551
Intraepithelial neoplasia of the anal canal in hemorrhoidal tissue: a study of 19 cases.
Foust RL, Dean PJ, Stoler MH, Moinuddin SM
Hum Pathol 1991 Jun;22(6):528-34. doi: 10.1016/0046-8177(91)90228-h. PMID: 1650751

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